YOL097C / WRS1

Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOL097C / WRS1

Click on Significant Values for Screen Details ID:SGTC_372|Compound:0155-0182|FD-Score:-6.01|P-value:3.25E-8 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.45|P-value:9.27E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-5.31|P-value:8.97E-7 ID:SGTC_549|Compound:1661-1316|FD-Score:3.65|P-value:6.03E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.91|P-value:2.61E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.99|P-value:1.63E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:4.24|P-value:8.31E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:5.45|P-value:6.25E-7 ID:SGTC_931|Compound:2812-0076|FD-Score:3.57|P-value:7.83E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.07|P-value:1.54E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.00|P-value:1.94E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.21|P-value:7.52E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.54|P-value:7.09E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.97|P-value:2.10E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.94|P-value:5.61E-6 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.87|P-value:2.98E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:4.19|P-value:9.92E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:7.26|P-value:4.93E-11 ID:SGTC_1708|Compound:st033234|FD-Score:4.46|P-value:3.68E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-7.03|P-value:1.38E-10 ID:SGTC_1734|Compound:st037168|FD-Score:3.85|P-value:3.20E-4 ID:SGTC_1736|Compound:st036774|FD-Score:-3.64|P-value:5.15E-4 ID:SGTC_1741|Compound:st038134|FD-Score:7.33|P-value:3.39E-11 ID:SGTC_1884|Compound:5633444|FD-Score:-3.48|P-value:8.41E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.55|P-value:8.18E-4 ID:SGTC_1975|Compound:st070967|FD-Score:4.52|P-value:2.94E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.74|P-value:4.55E-4 ID:SGTC_2229|Compound:7354935|FD-Score:5.85|P-value:9.62E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.84|P-value:3.25E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.90|P-value:6.74E-6 ID:SGTC_2379|Compound:9035213|FD-Score:4.57|P-value:2.49E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.90|P-value:2.70E-4 ID:SGTC_2428|Compound:5615643|FD-Score:6.07|P-value:3.29E-8 ID:SGTC_2618|Compound:avocadyne|FD-Score:4.73|P-value:1.33E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.57|P-value:7.72E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-5.27|P-value:1.06E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.20|P-value:9.64E-5 ID:SGTC_2713|Compound:st079149|FD-Score:-3.49|P-value:8.21E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-4.96|P-value:4.09E-6 ID:SGTC_2800|Compound:7887935|FD-Score:4.06|P-value:1.57E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.54|P-value:8.51E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-5.14|P-value:1.92E-6 ID:SGTC_3141|Compound:9094609|FD-Score:5.01|P-value:4.25E-6 ID:SGTC_3143|Compound:9086658|FD-Score:4.30|P-value:6.73E-5 ID:SGTC_3334|Compound:9142812|FD-Score:-3.87|P-value:2.45E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.01|P-value:3.25E-8 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.45|P-value:9.27E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-5.31|P-value:8.97E-7 ID:SGTC_549|Compound:1661-1316|FD-Score:3.65|P-value:6.03E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.91|P-value:2.61E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.99|P-value:1.63E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:4.24|P-value:8.31E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:5.45|P-value:6.25E-7 ID:SGTC_931|Compound:2812-0076|FD-Score:3.57|P-value:7.83E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.07|P-value:1.54E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.00|P-value:1.94E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.21|P-value:7.52E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.54|P-value:7.09E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.97|P-value:2.10E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.94|P-value:5.61E-6 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.87|P-value:2.98E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:4.19|P-value:9.92E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:7.26|P-value:4.93E-11 ID:SGTC_1708|Compound:st033234|FD-Score:4.46|P-value:3.68E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-7.03|P-value:1.38E-10 ID:SGTC_1734|Compound:st037168|FD-Score:3.85|P-value:3.20E-4 ID:SGTC_1736|Compound:st036774|FD-Score:-3.64|P-value:5.15E-4 ID:SGTC_1741|Compound:st038134|FD-Score:7.33|P-value:3.39E-11 ID:SGTC_1884|Compound:5633444|FD-Score:-3.48|P-value:8.41E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.55|P-value:8.18E-4 ID:SGTC_1975|Compound:st070967|FD-Score:4.52|P-value:2.94E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.74|P-value:4.55E-4 ID:SGTC_2229|Compound:7354935|FD-Score:5.85|P-value:9.62E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.84|P-value:3.25E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.90|P-value:6.74E-6 ID:SGTC_2379|Compound:9035213|FD-Score:4.57|P-value:2.49E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.90|P-value:2.70E-4 ID:SGTC_2428|Compound:5615643|FD-Score:6.07|P-value:3.29E-8 ID:SGTC_2618|Compound:avocadyne|FD-Score:4.73|P-value:1.33E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.57|P-value:7.72E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-5.27|P-value:1.06E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.20|P-value:9.64E-5 ID:SGTC_2713|Compound:st079149|FD-Score:-3.49|P-value:8.21E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-4.96|P-value:4.09E-6 ID:SGTC_2800|Compound:7887935|FD-Score:4.06|P-value:1.57E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.54|P-value:8.51E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-5.14|P-value:1.92E-6 ID:SGTC_3141|Compound:9094609|FD-Score:5.01|P-value:4.25E-6 ID:SGTC_3143|Compound:9086658|FD-Score:4.30|P-value:6.73E-5 ID:SGTC_3334|Compound:9142812|FD-Score:-3.87|P-value:2.45E-4

Top fitness defect scores for YOL097C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1741 st038134 7.33 10.2 µM 3.39E-11 1 1.17E-13 1.85
2 SGTC_1527 coumarin 7.26 137.0 µM 4.93E-11 2 1.87E-13 1.38
3 SGTC_2428 5615643 6.07 7.8 µM 3.29E-8 3 6.34E-10 0.87
4 SGTC_2229 7354935 5.85 190.0 µM 9.62E-8 RSC complex & mRNA processing 13 2.42E-9 0.49
5 SGTC_926 2268-1401 5.45 59.4 µM 6.25E-7 TSC3-RPN4 3 2.50E-8 0.32
6 SGTC_3141 9094609 5.01 49.5 µM 4.25E-6 iron homeostasis 9 2.74E-7 0.59
7 SGTC_1193 1488-0126 4.94 41.5 µM 5.61E-6 1 3.87E-7 0.47
8 SGTC_2282 7944268 4.90 200.0 µM 6.74E-6 RPP1 & pyrimidine depletion 7 4.86E-7 0.96
9 SGTC_2618 avocadyne 4.73 43.4 µM 1.33E-5 2 1.14E-6 0.69
10 SGTC_2379 9035213 4.57 200.0 µM 2.49E-5 2 2.48E-6 0.43
11 SGTC_1975 st070967 4.52 30.8 µM 2.94E-5 8 3.05E-6 0.45
12 SGTC_1708 st033234 4.46 31.8 µM 3.68E-5 1 4.04E-6 0.63
13 SGTC_3143 9086658 4.30 49.5 µM 6.73E-5 9 8.56E-6 0.12
14 SGTC_705 1124-0212 4.24 310.0 µM 8.31E-5 4 1.11E-5 0.20
15 SGTC_2687 chenodiol 4.20 100.0 µM 9.64E-5 2 1.34E-5 0.20
16 SGTC_1349 flufenamic acid 4.19 69.0 µM 9.92E-5 1 1.39E-5 0.65
17 SGTC_1019 4262-0212 4.07 3.4 µM 1.54E-4 ergosterol depletion effects on membrane 12 2.40E-5 0.01
18 SGTC_2800 7887935 4.06 81.8 µM 1.57E-4 RPP1 & pyrimidine depletion 9 2.45E-5 0.20
19 SGTC_1022 4477-0945 4.00 21.3 µM 1.94E-4 3 3.21E-5 0.03
20 SGTC_1156 4092-0367 3.97 4.9 µM 2.10E-4 3 3.52E-5 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.46E-15 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.096 2.85E-8 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.096 3.09E-8 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.093 8.04E-8 YFL055W AGP3 hom Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
0.092 1.02E-7 YHR101C BIG1 het Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
0.091 1.14E-7 YDR215C_d YDR215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
0.090 1.64E-7 YKR045C_p YKR045C_p hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
0.088 3.16E-7 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.086 6.30E-7 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.084 1.05E-6 YDR214W AHA1 hom Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress
0.084 1.13E-6 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.084 1.20E-6 YKL089W MIF2 het Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3
0.084 1.20E-6 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.083 1.51E-6 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.082 2.22E-6 YGL136C MRM2 hom Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ