YOL097W-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL097W-A / YOL097W-A

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.48|P-value:2.95E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.81|P-value:8.37E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:3.13|P-value:9.95E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.29|P-value:5.63E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:-3.82|P-value:7.65E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.53|P-value:2.38E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:3.15|P-value:9.36E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.76|P-value:9.71E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.62|P-value:1.77E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.55|P-value:2.29E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.30|P-value:5.37E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.55|P-value:3.27E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:3.38|P-value:4.27E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:-4.17|P-value:1.80E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:4.54|P-value:3.59E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:3.21|P-value:7.70E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.27|P-value:6.14E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.39|P-value:4.08E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.89|P-value:6.10E-5 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.41|P-value:3.60E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.16|P-value:2.03E-5 ID:SGTC_1606|Compound:st000094|FD-Score:-3.33|P-value:4.80E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.60|P-value:1.92E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.89|P-value:6.03E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-3.87|P-value:6.25E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.84|P-value:7.38E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.73|P-value:1.12E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.45|P-value:3.30E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.47|P-value:3.01E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.66|P-value:1.42E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.31|P-value:5.41E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.23|P-value:7.21E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-4.18|P-value:1.76E-5 ID:SGTC_2239|Compound:6685329|FD-Score:-3.32|P-value:5.03E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-6.54|P-value:4.86E-11 ID:SGTC_2246|Compound:7293507|FD-Score:-3.92|P-value:5.12E-5 ID:SGTC_2285|Compound:7945142|FD-Score:4.12|P-value:2.36E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.43|P-value:3.39E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.74|P-value:1.10E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.04|P-value:3.12E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.47|P-value:4.94E-6 ID:SGTC_2585|Compound:alliin|FD-Score:3.68|P-value:1.38E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-3.26|P-value:6.21E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-3.52|P-value:2.48E-4 ID:SGTC_2698|Compound:st077697|FD-Score:5.76|P-value:6.35E-9 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.65|P-value:1.56E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.37|P-value:4.18E-4 ID:SGTC_2813|Compound:7971799|FD-Score:5.36|P-value:6.03E-8 ID:SGTC_2954|Compound:9074818|FD-Score:-3.32|P-value:4.97E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.17|P-value:8.42E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.23|P-value:7.03E-4 ID:SGTC_3275|Compound:9138069|FD-Score:3.18|P-value:8.37E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.48|P-value:2.95E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.81|P-value:8.37E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:3.13|P-value:9.95E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.29|P-value:5.63E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:-3.82|P-value:7.65E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.53|P-value:2.38E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:3.15|P-value:9.36E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.76|P-value:9.71E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.62|P-value:1.77E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.55|P-value:2.29E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.30|P-value:5.37E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.55|P-value:3.27E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:3.38|P-value:4.27E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:-4.17|P-value:1.80E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:4.54|P-value:3.59E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:3.21|P-value:7.70E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.27|P-value:6.14E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.39|P-value:4.08E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.89|P-value:6.10E-5 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.41|P-value:3.60E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.16|P-value:2.03E-5 ID:SGTC_1606|Compound:st000094|FD-Score:-3.33|P-value:4.80E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.60|P-value:1.92E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.89|P-value:6.03E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-3.87|P-value:6.25E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.84|P-value:7.38E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.73|P-value:1.12E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.45|P-value:3.30E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.47|P-value:3.01E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.66|P-value:1.42E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.31|P-value:5.41E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.23|P-value:7.21E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-4.18|P-value:1.76E-5 ID:SGTC_2239|Compound:6685329|FD-Score:-3.32|P-value:5.03E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-6.54|P-value:4.86E-11 ID:SGTC_2246|Compound:7293507|FD-Score:-3.92|P-value:5.12E-5 ID:SGTC_2285|Compound:7945142|FD-Score:4.12|P-value:2.36E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.43|P-value:3.39E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.74|P-value:1.10E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.04|P-value:3.12E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.47|P-value:4.94E-6 ID:SGTC_2585|Compound:alliin|FD-Score:3.68|P-value:1.38E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-3.26|P-value:6.21E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-3.52|P-value:2.48E-4 ID:SGTC_2698|Compound:st077697|FD-Score:5.76|P-value:6.35E-9 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.65|P-value:1.56E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.37|P-value:4.18E-4 ID:SGTC_2813|Compound:7971799|FD-Score:5.36|P-value:6.03E-8 ID:SGTC_2954|Compound:9074818|FD-Score:-3.32|P-value:4.97E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.17|P-value:8.42E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.23|P-value:7.03E-4 ID:SGTC_3275|Compound:9138069|FD-Score:3.18|P-value:8.37E-4

Top fitness defect scores for YOL097W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2698 st077697 5.76 67.5 µM 6.35E-9 3 4.23E-9
2 SGTC_2813 7971799 5.36 71.4 µM 6.03E-8 4 4.23E-8
3 SGTC_770 0389-1121 4.54 67.2 µM 3.59E-6 RPP1 & pyrimidine depletion 14 2.76E-6
4 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 4.47 13.2 µM 4.94E-6 16 3.83E-6
5 SGTC_1599 8-chlro-1-tetrahydronorharmanone 4.16 90.6 µM 2.03E-5 31 1.62E-5
6 SGTC_2285 7945142 4.12 200.0 µM 2.36E-5 19 1.90E-5
7 SGTC_1635 st007035 3.89 42.4 µM 6.03E-5 215 4.95E-5
8 SGTC_1173 0443-0020 3.89 122.0 µM 6.10E-5 TSC3-RPN4 36 5.01E-5
9 SGTC_1879 gemcitabine 3.84 100.0 µM 7.38E-5 16 6.09E-5
10 SGTC_47 0149-0135 3.81 24.2 µM 8.37E-5 TSC3-RPN4 22 6.92E-5
11 SGTC_2484 5809818 3.74 12.0 µM 1.10E-4 21 9.18E-5
12 SGTC_2585 alliin 3.68 100.0 µM 1.38E-4 34 1.15E-4
13 SGTC_2762 leflunomide 3.65 42.1 µM 1.56E-4 43 1.31E-4
14 SGTC_536 3852-0578 3.62 10.6 µM 1.77E-4 39 1.49E-4
15 SGTC_1631 benzylvanillin 3.60 81.9 µM 1.92E-4 Golgi 38 1.62E-4
16 SGTC_596 1155-0152 3.55 116.0 µM 2.29E-4 TRP & mitochondrial translation 54 1.94E-4
17 SGTC_4 0960-0234 3.48 25.7 µM 2.95E-4 Golgi 21 2.51E-4
18 SGTC_1934 st074720 3.47 32.6 µM 3.01E-4 79 2.57E-4
19 SGTC_1929 genistein trimethyl ether 3.45 50.5 µM 3.30E-4 30 2.82E-4
20 SGTC_922 1866-0035 3.39 480.0 µM 4.08E-4 excess fatty acid 91 3.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 6.74E-11 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.105 9.42E-10 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.102 3.43E-9 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.098 1.19E-8 YCR043C_p YCR043C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
0.093 6.55E-8 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.088 3.35E-7 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.087 4.96E-7 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.086 5.98E-7 YBR044C TCM62 hom Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
0.086 6.67E-7 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.086 6.88E-7 YGL235W_p YGL235W_p hom Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.085 7.82E-7 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.084 1.24E-6 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.083 1.30E-6 YGR003W CUL3 hom Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3
0.082 1.76E-6 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.082 2.22E-6 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents