YOL098C_p

Putative metalloprotease

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL098C / YOL098C

Click on Significant Values for Screen Details ID:SGTC_94|Compound:0334-0113|FD-Score:3.39|P-value:3.03E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.25|P-value:4.37E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.11|P-value:8.45E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:-3.21|P-value:5.00E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.08|P-value:9.24E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.21|P-value:5.93E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.36|P-value:3.35E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:5.62|P-value:6.16E-9 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.09|P-value:7.78E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.38|P-value:3.13E-4 ID:SGTC_484|Compound:loperamide|FD-Score:4.12|P-value:1.53E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.06|P-value:9.89E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.30|P-value:4.20E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:-3.89|P-value:3.40E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:6.37|P-value:5.23E-11 ID:SGTC_970|Compound:1315-0089|FD-Score:3.16|P-value:7.01E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.37|P-value:3.33E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.35|P-value:5.29E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.13|P-value:7.84E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.95|P-value:3.25E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.55|P-value:2.00E-6 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.60|P-value:1.34E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.98|P-value:2.79E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.33|P-value:5.70E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.84|P-value:3.63E-7 ID:SGTC_1379|Compound:2144-0755|FD-Score:5.79|P-value:2.13E-9 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.11|P-value:1.29E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:8.34|P-value:1.22E-17 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.19|P-value:1.13E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.50|P-value:1.99E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.95|P-value:3.23E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.68|P-value:9.80E-5 ID:SGTC_1518|Compound:st038567|FD-Score:3.64|P-value:1.18E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.07|P-value:9.66E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.56|P-value:1.30E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.52|P-value:1.86E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-4.90|P-value:2.73E-7 ID:SGTC_1717|Compound:st033143|FD-Score:-4.74|P-value:6.10E-7 ID:SGTC_1865|Compound:st057639|FD-Score:4.00|P-value:2.59E-5 ID:SGTC_1992|Compound:st073643|FD-Score:3.42|P-value:2.73E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.09|P-value:8.84E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.26|P-value:4.85E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-3.08|P-value:7.98E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.16|P-value:5.95E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.41|P-value:2.82E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.55|P-value:1.67E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.59|P-value:1.40E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.10|P-value:8.74E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.74|P-value:7.69E-7 ID:SGTC_2883|Compound:9059145|FD-Score:3.15|P-value:7.41E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.27|P-value:4.80E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-5.24|P-value:4.25E-8 ID:SGTC_3305|Compound:9127027|FD-Score:-3.07|P-value:8.17E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.43|P-value:2.21E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.39|P-value:3.03E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.25|P-value:4.37E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.11|P-value:8.45E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:-3.21|P-value:5.00E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.08|P-value:9.24E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.21|P-value:5.93E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.36|P-value:3.35E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:5.62|P-value:6.16E-9 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.09|P-value:7.78E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.38|P-value:3.13E-4 ID:SGTC_484|Compound:loperamide|FD-Score:4.12|P-value:1.53E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.06|P-value:9.89E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.30|P-value:4.20E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:-3.89|P-value:3.40E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:6.37|P-value:5.23E-11 ID:SGTC_970|Compound:1315-0089|FD-Score:3.16|P-value:7.01E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.37|P-value:3.33E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.35|P-value:5.29E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.13|P-value:7.84E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.95|P-value:3.25E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.55|P-value:2.00E-6 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.60|P-value:1.34E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.98|P-value:2.79E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.33|P-value:5.70E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.84|P-value:3.63E-7 ID:SGTC_1379|Compound:2144-0755|FD-Score:5.79|P-value:2.13E-9 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.11|P-value:1.29E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:8.34|P-value:1.22E-17 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.19|P-value:1.13E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.50|P-value:1.99E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.95|P-value:3.23E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.68|P-value:9.80E-5 ID:SGTC_1518|Compound:st038567|FD-Score:3.64|P-value:1.18E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.07|P-value:9.66E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.56|P-value:1.30E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.52|P-value:1.86E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-4.90|P-value:2.73E-7 ID:SGTC_1717|Compound:st033143|FD-Score:-4.74|P-value:6.10E-7 ID:SGTC_1865|Compound:st057639|FD-Score:4.00|P-value:2.59E-5 ID:SGTC_1992|Compound:st073643|FD-Score:3.42|P-value:2.73E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.09|P-value:8.84E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.26|P-value:4.85E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-3.08|P-value:7.98E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.16|P-value:5.95E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.41|P-value:2.82E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.55|P-value:1.67E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.59|P-value:1.40E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.10|P-value:8.74E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.74|P-value:7.69E-7 ID:SGTC_2883|Compound:9059145|FD-Score:3.15|P-value:7.41E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.27|P-value:4.80E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-5.24|P-value:4.25E-8 ID:SGTC_3305|Compound:9127027|FD-Score:-3.07|P-value:8.17E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.43|P-value:2.21E-4

Top fitness defect scores for YOL098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1381 2324-0066 8.34 62.1 µM 1.22E-17 4 3.56E-17
2 SGTC_925 2064-1272 6.37 59.6 µM 5.23E-11 2 9.48E-11
3 SGTC_1379 2144-0755 5.79 36.5 µM 2.13E-9 5 3.44E-9
4 SGTC_339 3091-4833 5.62 71.4 µM 6.16E-9 iron homeostasis 4 9.65E-9
5 SGTC_2749 bexarotene 4.74 57.4 µM 7.69E-7 12 1.04E-6
6 SGTC_1168 k815-0004 4.55 80.5 µM 2.00E-6 DNA damage response 9 2.63E-6
7 SGTC_977 1348-1378 4.35 135.0 µM 5.29E-6 16 6.78E-6
8 SGTC_1311 1190-0148 4.33 100.0 µM 5.70E-6 azole & statin 21 7.29E-6
9 SGTC_1429 4049-0205 4.19 9.5 µM 1.13E-5 7 1.42E-5
10 SGTC_484 loperamide 4.12 105.0 µM 1.53E-5 3 1.91E-5
11 SGTC_1865 st057639 4.00 52.2 µM 2.59E-5 9 3.17E-5
12 SGTC_1249 0481-0015 3.98 10.2 µM 2.79E-5 20 3.41E-5
13 SGTC_1496 4469-0713 3.95 57.4 µM 3.23E-5 19 3.93E-5
14 SGTC_1092 toremifene 3.95 6.3 µM 3.25E-5 19 3.96E-5
15 SGTC_1514 1189-1591 3.68 158.0 µM 9.80E-5 45 1.16E-4
16 SGTC_1518 st038567 3.64 90.8 µM 1.18E-4 19 1.39E-4
17 SGTC_1244 0416-0015 3.60 52.5 µM 1.34E-4 ERG2 49 1.57E-4
18 SGTC_2643 anethole 3.59 100.0 µM 1.40E-4 22 1.63E-4
19 SGTC_2460 5552655 3.55 174.2 µM 1.67E-4 amide catabolism 40 1.94E-4
20 SGTC_1674 st016616 3.52 23.6 µM 1.86E-4 44 2.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 6.28E-16 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.114 4.21E-11 YBL029W_p YBL029W_p hom Non-essential protein of unknown function
0.106 6.49E-10 YGL261C_p PAU11_p hom Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2
0.099 7.91E-9 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.095 3.03E-8 YFL019C_d YFL019C_d hom Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
0.094 4.98E-8 YJR110W YMR1 hom Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family
0.090 2.04E-7 YGR051C_d YGR051C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
0.088 2.87E-7 YKL113C RAD27 hom 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
0.083 1.42E-6 YLR045C STU2 het Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
0.081 2.93E-6 YJR036C HUL4 hom Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex
0.076 1.16E-5 YML010W SPT5 het Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair
0.076 1.17E-5 YPR027C_p YPR027C_p hom Putative protein of unknown function
0.073 2.28E-5 YCR023C YCR023C hom Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
0.073 2.55E-5 YIR018W YAP5 hom Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication
0.072 2.74E-5 YPR032W SRO7 hom Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication