YOL099C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL099C / YOL099C

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.15|P-value:4.05E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.43|P-value:1.38E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.19|P-value:3.52E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.95|P-value:1.48E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:4.54|P-value:8.51E-7 ID:SGTC_381|Compound:3461-2219|FD-Score:-4.13|P-value:1.42E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:-4.88|P-value:3.51E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:4.22|P-value:4.10E-6 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:9.45|P-value:2.91E-23 ID:SGTC_398|Compound:bronopol|FD-Score:4.71|P-value:3.40E-7 ID:SGTC_401|Compound:neomycin|FD-Score:2.96|P-value:8.02E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.26|P-value:2.67E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:2.91|P-value:9.59E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.57|P-value:7.80E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.00|P-value:7.03E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.21|P-value:5.95E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.72|P-value:4.03E-5 ID:SGTC_677|Compound:0929-0063|FD-Score:3.17|P-value:3.74E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.17|P-value:7.00E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.09|P-value:9.39E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:2.90|P-value:9.89E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.29|P-value:2.96E-6 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.56|P-value:1.63E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-4.04|P-value:2.12E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.12|P-value:4.50E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.37|P-value:3.38E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.32|P-value:2.53E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:5.35|P-value:9.11E-9 ID:SGTC_858|Compound:0438-0351|FD-Score:4.47|P-value:1.19E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.08|P-value:5.22E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.07|P-value:8.59E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.21|P-value:3.28E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.20|P-value:3.37E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.39|P-value:1.64E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.15|P-value:4.03E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.13|P-value:4.38E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.95|P-value:1.50E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.90|P-value:1.89E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-3.63|P-value:1.20E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.13|P-value:4.34E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.18|P-value:6.84E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.45|P-value:1.28E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.21|P-value:3.29E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.89|P-value:1.98E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.02|P-value:6.45E-4 ID:SGTC_2412|Compound:st077135|FD-Score:2.98|P-value:7.63E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.34|P-value:1.96E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.26|P-value:3.40E-6 ID:SGTC_2652|Compound:actinonin|FD-Score:-3.10|P-value:8.80E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.65|P-value:1.12E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:5.49|P-value:4.01E-9 ID:SGTC_2839|Compound:9003951|FD-Score:3.99|P-value:1.22E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.06|P-value:5.76E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.11|P-value:4.64E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.82|P-value:5.48E-5 ID:SGTC_3128|Compound:9127691|FD-Score:4.44|P-value:1.42E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.09|P-value:5.07E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.11|P-value:4.79E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.15|P-value:4.08E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.06|P-value:5.70E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.48|P-value:1.12E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.15|P-value:4.05E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.43|P-value:1.38E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.19|P-value:3.52E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.95|P-value:1.48E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:4.54|P-value:8.51E-7 ID:SGTC_381|Compound:3461-2219|FD-Score:-4.13|P-value:1.42E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:-4.88|P-value:3.51E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:4.22|P-value:4.10E-6 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:9.45|P-value:2.91E-23 ID:SGTC_398|Compound:bronopol|FD-Score:4.71|P-value:3.40E-7 ID:SGTC_401|Compound:neomycin|FD-Score:2.96|P-value:8.02E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.26|P-value:2.67E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:2.91|P-value:9.59E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.57|P-value:7.80E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.00|P-value:7.03E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.21|P-value:5.95E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.72|P-value:4.03E-5 ID:SGTC_677|Compound:0929-0063|FD-Score:3.17|P-value:3.74E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.17|P-value:7.00E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.09|P-value:9.39E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:2.90|P-value:9.89E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.29|P-value:2.96E-6 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.56|P-value:1.63E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-4.04|P-value:2.12E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.12|P-value:4.50E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.37|P-value:3.38E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.32|P-value:2.53E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:5.35|P-value:9.11E-9 ID:SGTC_858|Compound:0438-0351|FD-Score:4.47|P-value:1.19E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.08|P-value:5.22E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.07|P-value:8.59E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.21|P-value:3.28E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.20|P-value:3.37E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.39|P-value:1.64E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.15|P-value:4.03E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.13|P-value:4.38E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.95|P-value:1.50E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.90|P-value:1.89E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-3.63|P-value:1.20E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.13|P-value:4.34E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.18|P-value:6.84E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.45|P-value:1.28E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.21|P-value:3.29E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.89|P-value:1.98E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.02|P-value:6.45E-4 ID:SGTC_2412|Compound:st077135|FD-Score:2.98|P-value:7.63E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.34|P-value:1.96E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.26|P-value:3.40E-6 ID:SGTC_2652|Compound:actinonin|FD-Score:-3.10|P-value:8.80E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.65|P-value:1.12E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:5.49|P-value:4.01E-9 ID:SGTC_2839|Compound:9003951|FD-Score:3.99|P-value:1.22E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.06|P-value:5.76E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.11|P-value:4.64E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.82|P-value:5.48E-5 ID:SGTC_3128|Compound:9127691|FD-Score:4.44|P-value:1.42E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.09|P-value:5.07E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.11|P-value:4.79E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.15|P-value:4.08E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.06|P-value:5.70E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.48|P-value:1.12E-4

Top fitness defect scores for YOL099C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_390 dec-rvkr-cmk 9.45 16.7 µM 2.91E-23 calcium & mitochondrial duress 3 1.76E-21
2 SGTC_2722 naftopidil 5.49 47.2 µM 4.01E-9 1 2.04E-8
3 SGTC_806 3966-4455 5.35 5.9 µM 9.11E-9 5 4.34E-8
4 SGTC_398 bronopol 4.71 33.3 µM 3.40E-7 RNA processing & uracil transport 20 1.22E-6
5 SGTC_379 3970-0972 4.54 5.9 µM 8.51E-7 tubulin folding & SWR complex 19 2.83E-6
6 SGTC_858 0438-0351 4.47 2.8 µM 1.19E-6 copper-dependent oxidative stress 12 3.86E-6
7 SGTC_3128 9127691 4.44 49.5 µM 1.42E-6 15 4.53E-6
8 SGTC_804 1595-0054 4.32 20.9 µM 2.53E-6 sphingolipid biosynthesis & PDR1 28 7.70E-6
9 SGTC_742 0kpi-0133 4.29 140.0 µM 2.96E-6 ERG2 18 8.90E-6
10 SGTC_2437 5741531 4.26 144.2 µM 3.40E-6 28 1.01E-5
11 SGTC_386 1509-0011 4.22 3.1 µM 4.10E-6 132 1.20E-5
12 SGTC_1078 idebenone 4.07 36.1 µM 8.59E-6 Golgi 39 2.37E-5
13 SGTC_2839 9003951 3.99 26.0 µM 1.22E-5 10 3.26E-5
14 SGTC_373 0844-0104 3.95 25.9 µM 1.48E-5 ERAD & cell cycle 45 3.91E-5
15 SGTC_1361 1608-0041 3.95 5.6 µM 1.50E-5 RPP1 & pyrimidine depletion 18 3.96E-5
16 SGTC_1407 3909-7909 3.90 12.3 µM 1.89E-5 60S ribosome export 14 4.88E-5
17 SGTC_2317 5986382 3.89 200.0 µM 1.98E-5 15 5.09E-5
18 SGTC_647 0140-0236 3.72 81.0 µM 4.03E-5 12 9.79E-5
19 SGTC_454 lyso-paf C-16 3.57 6.7 µM 7.80E-5 31 1.79E-4
20 SGTC_3354 9151612 3.48 71.4 µM 1.12E-4 25 2.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.11E-10 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.104 1.86E-9 YDR155C CPR1 hom Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress
0.099 7.99E-9 YOR219C STE13 hom Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
0.099 1.04E-8 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.094 4.89E-8 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.092 1.01E-7 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.089 2.81E-7 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.085 7.40E-7 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.082 2.09E-6 YMR256C COX7 hom Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.082 2.18E-6 YDL146W LDB17 hom Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
0.080 3.13E-6 YPL076W GPI2 het Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein
0.077 9.05E-6 YLR287C-A RPS30A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication
0.077 9.47E-6 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.076 1.04E-5 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.076 1.06E-5 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN