YOL101C / IZH4

Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL101C / IZH4

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-5.25|P-value:5.15E-8 ID:SGTC_42|Compound:0133-0086|FD-Score:4.10|P-value:2.28E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.88|P-value:5.71E-5 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.50|P-value:1.88E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:-3.54|P-value:1.58E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-7.06|P-value:4.62E-13 ID:SGTC_404|Compound:fumagillin|FD-Score:3.15|P-value:9.03E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.42|P-value:3.47E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.99|P-value:3.66E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:4.44|P-value:5.01E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-4.46|P-value:2.96E-6 ID:SGTC_917|Compound:harmaline|FD-Score:-4.21|P-value:9.43E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:3.64|P-value:1.53E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.07|P-value:8.68E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.90|P-value:5.42E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:3.39|P-value:3.87E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.57|P-value:2.65E-6 ID:SGTC_1851|Compound:st056236|FD-Score:3.33|P-value:4.87E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.34|P-value:4.55E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.84|P-value:2.81E-9 ID:SGTC_2023|Compound:5144124|FD-Score:-3.25|P-value:4.70E-4 ID:SGTC_2090|Compound:5301565|FD-Score:-3.18|P-value:5.92E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.08|P-value:2.51E-5 ID:SGTC_2282|Compound:7944268|FD-Score:-3.74|P-value:7.05E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.60|P-value:1.75E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.04|P-value:9.73E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:5.37|P-value:4.41E-8 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:5.12|P-value:1.72E-7 ID:SGTC_2521|Compound:angolensin|FD-Score:5.09|P-value:1.98E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.97|P-value:3.92E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.29|P-value:5.52E-4 ID:SGTC_2695|Compound:st077686|FD-Score:5.50|P-value:2.05E-8 ID:SGTC_2813|Compound:7971799|FD-Score:5.20|P-value:1.08E-7 ID:SGTC_2818|Compound:7996756|FD-Score:3.25|P-value:6.35E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.30|P-value:5.33E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.19|P-value:7.80E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.72|P-value:1.34E-6 ID:SGTC_2999|Compound:9069765|FD-Score:3.56|P-value:2.06E-4 ID:SGTC_3253|Compound:9135987|FD-Score:4.57|P-value:2.64E-6 ID:SGTC_3259|Compound:9138485|FD-Score:-3.06|P-value:9.18E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.98|P-value:3.82E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.38|P-value:4.04E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-5.25|P-value:5.15E-8 ID:SGTC_42|Compound:0133-0086|FD-Score:4.10|P-value:2.28E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.88|P-value:5.71E-5 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.50|P-value:1.88E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:-3.54|P-value:1.58E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-7.06|P-value:4.62E-13 ID:SGTC_404|Compound:fumagillin|FD-Score:3.15|P-value:9.03E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.42|P-value:3.47E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.99|P-value:3.66E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:4.44|P-value:5.01E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-4.46|P-value:2.96E-6 ID:SGTC_917|Compound:harmaline|FD-Score:-4.21|P-value:9.43E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:3.64|P-value:1.53E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.07|P-value:8.68E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.90|P-value:5.42E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:3.39|P-value:3.87E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.57|P-value:2.65E-6 ID:SGTC_1851|Compound:st056236|FD-Score:3.33|P-value:4.87E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.34|P-value:4.55E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.84|P-value:2.81E-9 ID:SGTC_2023|Compound:5144124|FD-Score:-3.25|P-value:4.70E-4 ID:SGTC_2090|Compound:5301565|FD-Score:-3.18|P-value:5.92E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.08|P-value:2.51E-5 ID:SGTC_2282|Compound:7944268|FD-Score:-3.74|P-value:7.05E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.60|P-value:1.75E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.04|P-value:9.73E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:5.37|P-value:4.41E-8 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:5.12|P-value:1.72E-7 ID:SGTC_2521|Compound:angolensin|FD-Score:5.09|P-value:1.98E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.97|P-value:3.92E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.29|P-value:5.52E-4 ID:SGTC_2695|Compound:st077686|FD-Score:5.50|P-value:2.05E-8 ID:SGTC_2813|Compound:7971799|FD-Score:5.20|P-value:1.08E-7 ID:SGTC_2818|Compound:7996756|FD-Score:3.25|P-value:6.35E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.30|P-value:5.33E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.19|P-value:7.80E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.72|P-value:1.34E-6 ID:SGTC_2999|Compound:9069765|FD-Score:3.56|P-value:2.06E-4 ID:SGTC_3253|Compound:9135987|FD-Score:4.57|P-value:2.64E-6 ID:SGTC_3259|Compound:9138485|FD-Score:-3.06|P-value:9.18E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.98|P-value:3.82E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.38|P-value:4.04E-4

Top fitness defect scores for YOL101C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1926 methyl fluorone black 5.84 53.6 µM 2.81E-9 DNA intercalators 21 2.56E-9
2 SGTC_2695 st077686 5.50 52.0 µM 2.05E-8 11 1.86E-8
3 SGTC_2498 4'-Methoxychalcone 5.37 54.6 µM 4.41E-8 RPP1 & pyrimidine depletion 9 3.99E-8
4 SGTC_2813 7971799 5.20 71.4 µM 1.08E-7 6 9.81E-8
5 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 5.12 54.6 µM 1.72E-7 RPP1 & pyrimidine depletion 13 1.56E-7
6 SGTC_2521 angolensin 5.09 13.4 µM 1.98E-7 4 1.79E-7
7 SGTC_2996 9066192 4.72 71.4 µM 1.34E-6 12 1.21E-6
8 SGTC_3253 9135987 4.57 49.5 µM 2.64E-6 60S ribosome export 6 2.38E-6
9 SGTC_1674 st016616 4.57 23.6 µM 2.65E-6 16 2.39E-6
10 SGTC_632 0781-2353 4.44 4.7 µM 5.01E-6 Golgi 28 4.51E-6
11 SGTC_42 0133-0086 4.10 60.6 µM 2.28E-5 29 2.06E-5
12 SGTC_2274 7947094 4.08 46.1 µM 2.51E-5 35 2.26E-5
13 SGTC_444 curcumin 3.99 90.4 µM 3.66E-5 iron homeostasis 25 3.31E-5
14 SGTC_3283 9109332 3.98 35.8 µM 3.82E-5 DNA intercalators 15 3.45E-5
15 SGTC_2567 aureobasidin a 3.97 60.0 nM 3.92E-5 96 3.54E-5
16 SGTC_1251 0490-5699 3.90 265.0 µM 5.42E-5 35 4.89E-5
17 SGTC_69 0096-0274 3.88 206.7 µM 5.71E-5 mitochondrial processes 43 5.16E-5
18 SGTC_992 3909-8734 3.64 162.0 µM 1.53E-4 28 1.38E-4
19 SGTC_2325 6158266 3.60 200.0 µM 1.75E-4 37 1.58E-4
20 SGTC_2999 9069765 3.56 71.4 µM 2.06E-4 amide catabolism 45 1.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 3.57E-15 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.098 1.26E-8 YNL151C RPC31 het RNA polymerase III subunit C31
0.094 5.02E-8 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.093 7.31E-8 YDL026W_d YDL026W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.092 1.01E-7 YGL050W TYW3 hom tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
0.090 1.87E-7 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.086 6.81E-7 YIL002W-A_p YIL002W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.085 7.84E-7 YKL137W CMC1 hom Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
0.084 9.70E-7 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.084 1.24E-6 YGR179C OKP1 het Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
0.080 3.82E-6 YIL144W TID3 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
0.080 3.84E-6 YEL006W YEA6 hom Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
0.078 6.24E-6 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.077 8.00E-6 YBR178W_d YBR178W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C
0.076 1.07E-5 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W