YOL104C / NDJ1

Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL104C / NDJ1

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:-4.63|P-value:2.48E-6 ID:SGTC_55|Compound:0767-0285|FD-Score:3.06|P-value:7.31E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.47|P-value:2.10E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:3.55|P-value:1.17E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.04|P-value:7.78E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.25|P-value:3.64E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.30|P-value:3.03E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.83|P-value:3.76E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:5.01|P-value:1.30E-7 ID:SGTC_519|Compound:k048-0011|FD-Score:3.83|P-value:3.78E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:2.97|P-value:9.93E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:2.97|P-value:9.78E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.61|P-value:9.06E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.29|P-value:6.43E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.27|P-value:3.46E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.67|P-value:7.27E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.41|P-value:2.00E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.66|P-value:7.54E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.81|P-value:3.70E-7 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.02|P-value:1.24E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.72|P-value:1.28E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.42|P-value:4.09E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:2.98|P-value:9.42E-4 ID:SGTC_1616|Compound:st002734|FD-Score:4.18|P-value:7.99E-6 ID:SGTC_1637|Compound:st007924|FD-Score:3.13|P-value:5.61E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.56|P-value:1.33E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.29|P-value:3.13E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.77|P-value:4.84E-5 ID:SGTC_2035|Compound:5154463|FD-Score:3.16|P-value:5.09E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.22|P-value:4.05E-4 ID:SGTC_2162|Compound:5663267|FD-Score:-3.84|P-value:8.17E-5 ID:SGTC_2222|Compound:6885208|FD-Score:-3.43|P-value:3.94E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.96|P-value:2.09E-5 ID:SGTC_2308|Compound:7584454|FD-Score:-3.79|P-value:9.87E-5 ID:SGTC_2309|Compound:7664088|FD-Score:-3.83|P-value:8.46E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.85|P-value:7.72E-5 ID:SGTC_2440|Compound:5628896|FD-Score:3.02|P-value:8.24E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.04|P-value:7.85E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.16|P-value:5.63E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.01|P-value:1.69E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.47|P-value:3.42E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.08|P-value:1.24E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.12|P-value:5.79E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.39|P-value:2.19E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.24|P-value:7.72E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.52|P-value:1.31E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.30|P-value:3.03E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.27|P-value:6.83E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.51|P-value:1.37E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.94|P-value:1.86E-7 ID:SGTC_2800|Compound:7887935|FD-Score:4.46|P-value:2.16E-6 ID:SGTC_2835|Compound:9006588|FD-Score:4.58|P-value:1.21E-6 ID:SGTC_2855|Compound:9016525|FD-Score:2.98|P-value:9.55E-4 ID:SGTC_2891|Compound:9063876|FD-Score:3.09|P-value:6.49E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.15|P-value:5.28E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.71|P-value:6.11E-5 ID:SGTC_3128|Compound:9127691|FD-Score:3.00|P-value:8.78E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.19|P-value:4.59E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.46|P-value:1.64E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.20|P-value:4.48E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.32|P-value:2.86E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.90|P-value:6.28E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:-4.63|P-value:2.48E-6 ID:SGTC_55|Compound:0767-0285|FD-Score:3.06|P-value:7.31E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.47|P-value:2.10E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:3.55|P-value:1.17E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.04|P-value:7.78E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.25|P-value:3.64E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.30|P-value:3.03E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.83|P-value:3.76E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:5.01|P-value:1.30E-7 ID:SGTC_519|Compound:k048-0011|FD-Score:3.83|P-value:3.78E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:2.97|P-value:9.93E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:2.97|P-value:9.78E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.61|P-value:9.06E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.29|P-value:6.43E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.27|P-value:3.46E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.67|P-value:7.27E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.41|P-value:2.00E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.66|P-value:7.54E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.81|P-value:3.70E-7 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.02|P-value:1.24E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.72|P-value:1.28E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.42|P-value:4.09E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:2.98|P-value:9.42E-4 ID:SGTC_1616|Compound:st002734|FD-Score:4.18|P-value:7.99E-6 ID:SGTC_1637|Compound:st007924|FD-Score:3.13|P-value:5.61E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.56|P-value:1.33E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.29|P-value:3.13E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.77|P-value:4.84E-5 ID:SGTC_2035|Compound:5154463|FD-Score:3.16|P-value:5.09E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.22|P-value:4.05E-4 ID:SGTC_2162|Compound:5663267|FD-Score:-3.84|P-value:8.17E-5 ID:SGTC_2222|Compound:6885208|FD-Score:-3.43|P-value:3.94E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.96|P-value:2.09E-5 ID:SGTC_2308|Compound:7584454|FD-Score:-3.79|P-value:9.87E-5 ID:SGTC_2309|Compound:7664088|FD-Score:-3.83|P-value:8.46E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.85|P-value:7.72E-5 ID:SGTC_2440|Compound:5628896|FD-Score:3.02|P-value:8.24E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.04|P-value:7.85E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.16|P-value:5.63E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.01|P-value:1.69E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.47|P-value:3.42E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.08|P-value:1.24E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.12|P-value:5.79E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.39|P-value:2.19E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.24|P-value:7.72E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.52|P-value:1.31E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.30|P-value:3.03E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.27|P-value:6.83E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.51|P-value:1.37E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.94|P-value:1.86E-7 ID:SGTC_2800|Compound:7887935|FD-Score:4.46|P-value:2.16E-6 ID:SGTC_2835|Compound:9006588|FD-Score:4.58|P-value:1.21E-6 ID:SGTC_2855|Compound:9016525|FD-Score:2.98|P-value:9.55E-4 ID:SGTC_2891|Compound:9063876|FD-Score:3.09|P-value:6.49E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.15|P-value:5.28E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.71|P-value:6.11E-5 ID:SGTC_3128|Compound:9127691|FD-Score:3.00|P-value:8.78E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.19|P-value:4.59E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.46|P-value:1.64E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.20|P-value:4.48E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.32|P-value:2.86E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.90|P-value:6.28E-5

Top fitness defect scores for YOL104C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2540 epiandrosterone 5.16 100.0 µM 5.63E-8 30 1.21E-7
2 SGTC_1035 k081-0041 5.02 55.2 µM 1.24E-7 Golgi 11 2.61E-7
3 SGTC_464 bw-b 70c 5.01 158.0 µM 1.30E-7 5 2.73E-7
4 SGTC_2795 7780010 4.94 54.5 µM 1.86E-7 9 3.85E-7
5 SGTC_1031 k035-0009 4.81 16.0 µM 3.70E-7 12 7.50E-7
6 SGTC_2835 9006588 4.58 71.4 µM 1.21E-6 26 2.36E-6
7 SGTC_1787 fluconazole 4.56 80.0 µM 1.33E-6 iron homeostasis 15 2.59E-6
8 SGTC_61 0978-8327 4.47 98.6 µM 2.10E-6 ergosterol biosynthesis 20 4.00E-6
9 SGTC_2800 7887935 4.46 81.8 µM 2.16E-6 RPP1 & pyrimidine depletion 14 4.12E-6
10 SGTC_1616 st002734 4.18 56.1 µM 7.99E-6 24 1.45E-5
11 SGTC_2581 avocatin a 4.08 64.0 µM 1.24E-5 sphingolipid biosynthesis & PDR1 48 2.22E-5
12 SGTC_2573 2',4'-dihydroxychalcone 4.01 15.0 µM 1.69E-5 46 3.00E-5
13 SGTC_2290 7904846 3.96 200.0 µM 2.09E-5 20 3.67E-5
14 SGTC_388 3',4'-dichloroisocoumarin 3.83 16.7 µM 3.76E-5 16 6.45E-5
15 SGTC_519 k048-0011 3.83 62.8 µM 3.78E-5 26 6.49E-5
16 SGTC_1939 st074455 3.77 53.6 µM 4.84E-5 34 8.23E-5
17 SGTC_3108 9121785 3.71 49.5 µM 6.11E-5 18 1.03E-4
18 SGTC_948 3448-0295 3.67 75.3 µM 7.27E-5 37 1.22E-4
19 SGTC_1029 k015-0030 3.66 64.7 µM 7.54E-5 41 1.26E-4
20 SGTC_788 1182-0090 3.61 188.0 µM 9.06E-5 endomembrane recycling 94 1.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 3.81E-14 YNL141W AAH1 hom Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
0.089 2.32E-7 YPL192C PRM3 hom Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body
0.087 4.58E-7 YBL093C ROX3 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme
0.087 4.60E-7 YMR054W STV1 hom Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole
0.084 1.03E-6 YAL019W FUN30 hom Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate
0.083 1.41E-6 YHR156C LIN1 hom Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
0.081 2.94E-6 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.076 1.01E-5 YLR231C BNA5 hom Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.076 1.08E-5 YDR536W STL1 hom Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
0.075 1.29E-5 YEL042W GDA1 hom Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.074 1.60E-5 YBL011W SCT1 hom Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed
0.073 2.25E-5 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.073 2.44E-5 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.073 2.54E-5 YDR523C SPS1 hom Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
0.073 2.57E-5 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm