Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOL105C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.123 | 7.27E-13 | YNR033W | ABZ1 | hom | Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress |
0.090 | 1.82E-7 | YDR132C | YDR132C | hom | Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication |
0.087 | 4.14E-7 | YHR182W | YHR182W | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress |
0.083 | 1.60E-6 | YDR382W | RPP2B | hom | Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm |
0.081 | 2.32E-6 | YLR440C | SEC39 | het | Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope |
0.080 | 3.16E-6 | YGR064W_d | YGR064W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C |
0.076 | 9.50E-6 | YLR003C | CMS1 | hom | Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress |
0.076 | 1.09E-5 | YOL052C-A | DDR2 | hom | Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication |
0.076 | 1.12E-5 | YLR353W | BUD8 | hom | Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole |
0.074 | 1.95E-5 | YPL194W | DDC1 | hom | DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress |
0.073 | 2.21E-5 | YBL019W | APN2 | hom | Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII |
0.072 | 2.94E-5 | YLR257W | YLR257W | hom | Protein of unknown function; protein abundance increases in response to DNA replication stress |
0.071 | 3.47E-5 | YDR249C_p | YDR249C_p | hom | Putative protein of unknown function |
0.070 | 4.89E-5 | YBR193C | MED8 | het | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation |
0.069 | 5.63E-5 | YLR221C | RSA3 | hom | Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus |