YOL105C / WSC3

Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL105C / WSC3

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.19|P-value:4.19E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:3.44|P-value:1.25E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.54|P-value:8.44E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:4.50|P-value:8.84E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:4.42|P-value:1.36E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.52|P-value:1.07E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.81|P-value:2.57E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.94|P-value:1.67E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:6.25|P-value:1.67E-11 ID:SGTC_543|Compound:3844-1095|FD-Score:3.27|P-value:2.57E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.23|P-value:2.96E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.92|P-value:1.88E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:-4.83|P-value:1.82E-7 ID:SGTC_818|Compound:4072-2707|FD-Score:3.69|P-value:4.29E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.08|P-value:5.29E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.41|P-value:1.41E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.93|P-value:9.07E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:2.91|P-value:9.81E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.79|P-value:2.76E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:-2.98|P-value:8.82E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.28|P-value:2.71E-6 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.06|P-value:6.61E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.10|P-value:4.77E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.73|P-value:3.61E-5 ID:SGTC_1644|Compound:st010134|FD-Score:3.35|P-value:1.82E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.33|P-value:2.01E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.34|P-value:1.89E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.43|P-value:1.30E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-2.98|P-value:8.74E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-4.02|P-value:1.20E-5 ID:SGTC_1889|Compound:st059080|FD-Score:4.65|P-value:3.85E-7 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.72|P-value:3.76E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.64|P-value:5.39E-5 ID:SGTC_1991|Compound:st073000|FD-Score:-4.57|P-value:7.59E-7 ID:SGTC_2191|Compound:5911152|FD-Score:2.92|P-value:9.31E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.16|P-value:3.87E-4 ID:SGTC_2310|Compound:7668677|FD-Score:7.83|P-value:5.12E-17 ID:SGTC_2332|Compound:7982454|FD-Score:2.96|P-value:8.13E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.89|P-value:1.77E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.86|P-value:2.01E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.03|P-value:7.41E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.03|P-value:6.31E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.61|P-value:6.17E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.80|P-value:2.70E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.22|P-value:3.04E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:2.94|P-value:8.73E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.43|P-value:1.34E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.55|P-value:6.68E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.58|P-value:7.02E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.20|P-value:3.80E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.03|P-value:6.36E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.26|P-value:2.62E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-4.05|P-value:1.03E-5 ID:SGTC_2964|Compound:9083345|FD-Score:3.44|P-value:1.29E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.60|P-value:7.80E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.52|P-value:8.91E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-3.30|P-value:2.61E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.03|P-value:6.26E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-5.13|P-value:3.20E-8 ID:SGTC_3224|Compound:9130643|FD-Score:-6.89|P-value:1.82E-13 ID:SGTC_3235|Compound:9132602|FD-Score:-3.48|P-value:1.27E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-3.53|P-value:1.02E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.65|P-value:5.15E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:4.19|P-value:4.19E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:3.44|P-value:1.25E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.54|P-value:8.44E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:4.50|P-value:8.84E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:4.42|P-value:1.36E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.52|P-value:1.07E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.81|P-value:2.57E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.94|P-value:1.67E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:6.25|P-value:1.67E-11 ID:SGTC_543|Compound:3844-1095|FD-Score:3.27|P-value:2.57E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.23|P-value:2.96E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.92|P-value:1.88E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:-4.83|P-value:1.82E-7 ID:SGTC_818|Compound:4072-2707|FD-Score:3.69|P-value:4.29E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.08|P-value:5.29E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.41|P-value:1.41E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.93|P-value:9.07E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:2.91|P-value:9.81E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.79|P-value:2.76E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:-2.98|P-value:8.82E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.28|P-value:2.71E-6 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.06|P-value:6.61E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.10|P-value:4.77E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.73|P-value:3.61E-5 ID:SGTC_1644|Compound:st010134|FD-Score:3.35|P-value:1.82E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.33|P-value:2.01E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.34|P-value:1.89E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.43|P-value:1.30E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-2.98|P-value:8.74E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-4.02|P-value:1.20E-5 ID:SGTC_1889|Compound:st059080|FD-Score:4.65|P-value:3.85E-7 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.72|P-value:3.76E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.64|P-value:5.39E-5 ID:SGTC_1991|Compound:st073000|FD-Score:-4.57|P-value:7.59E-7 ID:SGTC_2191|Compound:5911152|FD-Score:2.92|P-value:9.31E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.16|P-value:3.87E-4 ID:SGTC_2310|Compound:7668677|FD-Score:7.83|P-value:5.12E-17 ID:SGTC_2332|Compound:7982454|FD-Score:2.96|P-value:8.13E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.89|P-value:1.77E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.86|P-value:2.01E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.03|P-value:7.41E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.03|P-value:6.31E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.61|P-value:6.17E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.80|P-value:2.70E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.22|P-value:3.04E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:2.94|P-value:8.73E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.43|P-value:1.34E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.55|P-value:6.68E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.58|P-value:7.02E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.20|P-value:3.80E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.03|P-value:6.36E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.26|P-value:2.62E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-4.05|P-value:1.03E-5 ID:SGTC_2964|Compound:9083345|FD-Score:3.44|P-value:1.29E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.60|P-value:7.80E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.52|P-value:8.91E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-3.30|P-value:2.61E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.03|P-value:6.26E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-5.13|P-value:3.20E-8 ID:SGTC_3224|Compound:9130643|FD-Score:-6.89|P-value:1.82E-13 ID:SGTC_3235|Compound:9132602|FD-Score:-3.48|P-value:1.27E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-3.53|P-value:1.02E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.65|P-value:5.15E-5

Top fitness defect scores for YOL105C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2310 7668677 7.83 200.0 µM 5.12E-17 2 2.40E-15
2 SGTC_516 3992-2719 6.25 87.3 µM 1.67E-11 4 2.04E-10
3 SGTC_1889 st059080 4.65 5.2 µM 3.85E-7 9 1.62E-6
4 SGTC_2629 bisabolol 4.55 100.0 µM 6.68E-7 13 2.66E-6
5 SGTC_350 k064-0020 4.50 19.8 µM 8.84E-7 heme requiring 19 3.41E-6
6 SGTC_358 0075-0058 4.42 9.4 µM 1.36E-6 45 5.00E-6
7 SGTC_1329 1447-1697 4.28 50.6 µM 2.71E-6 12 9.30E-6
8 SGTC_35 0133-0054 4.19 64.1 µM 4.19E-6 28 1.37E-5
9 SGTC_2390 9097792 3.89 176.6 µM 1.77E-5 15 4.98E-5
10 SGTC_2401 5128683 3.86 200.0 µM 2.01E-5 45 5.58E-5
11 SGTC_406 estrone 3.81 100.0 µM 2.57E-5 11 6.97E-5
12 SGTC_2570 licareol 3.80 100.0 µM 2.70E-5 35 7.27E-5
13 SGTC_1177 0983-0204 3.79 23.6 µM 2.76E-5 17 7.42E-5
14 SGTC_1608 st001473 3.73 40.5 µM 3.61E-5 41 9.44E-5
15 SGTC_1894 3',6'-dihydroxyflavone 3.72 78.7 µM 3.76E-5 15 9.78E-5
16 SGTC_818 4072-2707 3.69 53.5 µM 4.29E-5 21 1.10E-4
17 SGTC_3351 9150312 3.65 21.6 µM 5.15E-5 cell wall 40 1.30E-4
18 SGTC_1917 st066507 3.64 28.5 µM 5.39E-5 Golgi 51 1.35E-4
19 SGTC_2569 tetrandrine 3.61 100.0 µM 6.17E-5 33 1.52E-4
20 SGTC_2682 pyrogallin 3.58 40.0 µM 7.02E-5 copper-dependent oxidative stress 37 1.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 7.27E-13 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.090 1.82E-7 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.087 4.14E-7 YHR182W YHR182W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.083 1.60E-6 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.081 2.32E-6 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.080 3.16E-6 YGR064W_d YGR064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C
0.076 9.50E-6 YLR003C CMS1 hom Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.076 1.09E-5 YOL052C-A DDR2 hom Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication
0.076 1.12E-5 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.074 1.95E-5 YPL194W DDC1 hom DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress
0.073 2.21E-5 YBL019W APN2 hom Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
0.072 2.94E-5 YLR257W YLR257W hom Protein of unknown function; protein abundance increases in response to DNA replication stress
0.071 3.47E-5 YDR249C_p YDR249C_p hom Putative protein of unknown function
0.070 4.89E-5 YBR193C MED8 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.069 5.63E-5 YLR221C RSA3 hom Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus