HIPHOP chemogenomics database

YOL105C / WSC3

Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis

Zygosity: Homozygous strain

fixedexpanded
Profile for YOL105C / WSC3

Click on Significant Values for Screen Details

Top fitness defect scores for YOL105C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2310	7668677	7.83	200.0 µM	5.12E-17		2	2.40E-15
2	SGTC_516	3992-2719	6.25	87.3 µM	1.67E-11		4	2.04E-10
3	SGTC_1889	st059080	4.65	5.2 µM	3.85E-7		9	1.62E-6
4	SGTC_2629	bisabolol	4.55	100.0 µM	6.68E-7		13	2.66E-6
5	SGTC_350	k064-0020	4.50	19.8 µM	8.84E-7	heme requiring	19	3.41E-6
6	SGTC_358	0075-0058	4.42	9.4 µM	1.36E-6		45	5.00E-6
7	SGTC_1329	1447-1697	4.28	50.6 µM	2.71E-6		12	9.30E-6
8	SGTC_35	0133-0054	4.19	64.1 µM	4.19E-6		28	1.37E-5
9	SGTC_2390	9097792	3.89	176.6 µM	1.77E-5		15	4.98E-5
10	SGTC_2401	5128683	3.86	200.0 µM	2.01E-5		45	5.58E-5
11	SGTC_406	estrone	3.81	100.0 µM	2.57E-5		11	6.97E-5
12	SGTC_2570	licareol	3.80	100.0 µM	2.70E-5		35	7.27E-5
13	SGTC_1177	0983-0204	3.79	23.6 µM	2.76E-5		17	7.42E-5
14	SGTC_1608	st001473	3.73	40.5 µM	3.61E-5		41	9.44E-5
15	SGTC_1894	3',6'-dihydroxyflavone	3.72	78.7 µM	3.76E-5		15	9.78E-5
16	SGTC_818	4072-2707	3.69	53.5 µM	4.29E-5		21	1.10E-4
17	SGTC_3351	9150312	3.65	21.6 µM	5.15E-5	cell wall	40	1.30E-4
18	SGTC_1917	st066507	3.64	28.5 µM	5.39E-5	Golgi	51	1.35E-4
19	SGTC_2569	tetrandrine	3.61	100.0 µM	6.17E-5		33	1.52E-4
20	SGTC_2682	pyrogallin	3.58	40.0 µM	7.02E-5	copper-dependent oxidative stress	37	1.71E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.123	7.27E-13	YNR033W	ABZ1	hom	Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.090	1.82E-7	YDR132C	YDR132C	hom	Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.087	4.14E-7	YHR182W	YHR182W	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.083	1.60E-6	YDR382W	RPP2B	hom	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.081	2.32E-6	YLR440C	SEC39	het	Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.080	3.16E-6	YGR064W_d	YGR064W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C
0.076	9.50E-6	YLR003C	CMS1	hom	Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.076	1.09E-5	YOL052C-A	DDR2	hom	Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication
0.076	1.12E-5	YLR353W	BUD8	hom	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.074	1.95E-5	YPL194W	DDC1	hom	DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress
0.073	2.21E-5	YBL019W	APN2	hom	Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
0.072	2.94E-5	YLR257W	YLR257W	hom	Protein of unknown function; protein abundance increases in response to DNA replication stress
0.071	3.47E-5	YDR249C_p	YDR249C_p	hom	Putative protein of unknown function
0.070	4.89E-5	YBR193C	MED8	het	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.069	5.63E-5	YLR221C	RSA3	hom	Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus