YOL106W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL106W / YOL106W

Click on Significant Values for Screen Details ID:SGTC_181|Compound:1447-1644|FD-Score:-3.51|P-value:9.21E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:3.48|P-value:1.10E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.16|P-value:2.22E-8 ID:SGTC_379|Compound:3970-0972|FD-Score:3.08|P-value:5.57E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.37|P-value:1.78E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.54|P-value:7.42E-7 ID:SGTC_884|Compound:0851-0618|FD-Score:2.97|P-value:8.32E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-2.99|P-value:7.23E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-4.34|P-value:1.90E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.00|P-value:7.46E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.55|P-value:7.74E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-5.40|P-value:4.47E-9 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.32|P-value:2.19E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.56|P-value:6.51E-7 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.12|P-value:4.69E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.97|P-value:8.20E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.82|P-value:2.51E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.15|P-value:5.48E-6 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.25|P-value:2.81E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.37|P-value:1.77E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:2.92|P-value:9.75E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.18|P-value:4.54E-6 ID:SGTC_1553|Compound:gossypol|FD-Score:3.47|P-value:1.19E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:4.71|P-value:2.96E-7 ID:SGTC_1590|Compound:st077108|FD-Score:3.02|P-value:6.83E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.02|P-value:6.96E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.23|P-value:3.08E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.50|P-value:1.01E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.81|P-value:2.62E-5 ID:SGTC_2049|Compound:5262831|FD-Score:-3.09|P-value:5.02E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.31|P-value:2.29E-4 ID:SGTC_2157|Compound:5649910|FD-Score:2.98|P-value:8.02E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.07|P-value:5.62E-4 ID:SGTC_2369|Compound:9071472|FD-Score:2.94|P-value:9.21E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.47|P-value:1.17E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.28|P-value:2.57E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.10|P-value:6.92E-6 ID:SGTC_2932|Compound:9016711|FD-Score:4.32|P-value:2.25E-6 ID:SGTC_2936|Compound:9038235|FD-Score:4.65|P-value:4.02E-7 ID:SGTC_2938|Compound:9059746|FD-Score:3.63|P-value:5.85E-5 ID:SGTC_3001|Compound:9076041|FD-Score:3.86|P-value:2.08E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.85|P-value:2.26E-5 ID:SGTC_3238|Compound:9133470|FD-Score:3.06|P-value:6.01E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.51|P-value:9.21E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:3.48|P-value:1.10E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.16|P-value:2.22E-8 ID:SGTC_379|Compound:3970-0972|FD-Score:3.08|P-value:5.57E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.37|P-value:1.78E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.54|P-value:7.42E-7 ID:SGTC_884|Compound:0851-0618|FD-Score:2.97|P-value:8.32E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-2.99|P-value:7.23E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-4.34|P-value:1.90E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.00|P-value:7.46E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.55|P-value:7.74E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-5.40|P-value:4.47E-9 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.32|P-value:2.19E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.56|P-value:6.51E-7 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.12|P-value:4.69E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.97|P-value:8.20E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.82|P-value:2.51E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.15|P-value:5.48E-6 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.25|P-value:2.81E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.37|P-value:1.77E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:2.92|P-value:9.75E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.18|P-value:4.54E-6 ID:SGTC_1553|Compound:gossypol|FD-Score:3.47|P-value:1.19E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:4.71|P-value:2.96E-7 ID:SGTC_1590|Compound:st077108|FD-Score:3.02|P-value:6.83E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.02|P-value:6.96E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.23|P-value:3.08E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.50|P-value:1.01E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.81|P-value:2.62E-5 ID:SGTC_2049|Compound:5262831|FD-Score:-3.09|P-value:5.02E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.31|P-value:2.29E-4 ID:SGTC_2157|Compound:5649910|FD-Score:2.98|P-value:8.02E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.07|P-value:5.62E-4 ID:SGTC_2369|Compound:9071472|FD-Score:2.94|P-value:9.21E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.47|P-value:1.17E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.28|P-value:2.57E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.10|P-value:6.92E-6 ID:SGTC_2932|Compound:9016711|FD-Score:4.32|P-value:2.25E-6 ID:SGTC_2936|Compound:9038235|FD-Score:4.65|P-value:4.02E-7 ID:SGTC_2938|Compound:9059746|FD-Score:3.63|P-value:5.85E-5 ID:SGTC_3001|Compound:9076041|FD-Score:3.86|P-value:2.08E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.85|P-value:2.26E-5 ID:SGTC_3238|Compound:9133470|FD-Score:3.06|P-value:6.01E-4

Top fitness defect scores for YOL106W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_365 0121-0052 5.16 13.6 µM 2.22E-8 mitochondrial response to ROS 27 1.25E-7
2 SGTC_1561 5-methoxyflavone 4.71 52.9 µM 2.96E-7 2 1.26E-6
3 SGTC_2936 9038235 4.65 15.6 µM 4.02E-7 9 1.65E-6
4 SGTC_1179 1021-1431 4.56 9.3 µM 6.51E-7 26 2.54E-6
5 SGTC_632 0781-2353 4.54 4.7 µM 7.42E-7 Golgi 22 2.85E-6
6 SGTC_1482 3346-2049 4.37 8.5 µM 1.77E-6 23 6.18E-6
7 SGTC_2932 9016711 4.32 44.5 µM 2.25E-6 36 7.67E-6
8 SGTC_1550 gossypolone 4.18 36.6 µM 4.54E-6 11 1.43E-5
9 SGTC_1309 pyrazolanthrone 4.15 13.4 µM 5.48E-6 18 1.69E-5
10 SGTC_2520 obtusaquinone 4.10 4.7 µM 6.92E-6 17 2.09E-5
11 SGTC_3001 9076041 3.86 71.4 µM 2.08E-5 15 5.57E-5
12 SGTC_3030 9087619 3.85 49.5 µM 2.26E-5 12 5.99E-5
13 SGTC_1278 0874-0585 3.82 172.0 µM 2.51E-5 15 6.57E-5
14 SGTC_2017 5132927 3.81 60.6 µM 2.62E-5 34 6.84E-5
15 SGTC_2938 9059746 3.63 27.3 µM 5.85E-5 fatty acid desaturase (OLE1) 46 1.40E-4
16 SGTC_1748 st037455 3.50 53.6 µM 1.01E-4 48 2.29E-4
17 SGTC_182 3448-4371 3.48 550.5 µM 1.10E-4 36 2.46E-4
18 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.47 200.0 µM 1.17E-4 24 2.60E-4
19 SGTC_1553 gossypol 3.47 38.6 µM 1.19E-4 5 2.64E-4
20 SGTC_386 1509-0011 3.37 3.1 µM 1.78E-4 172 3.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 9.73E-17 YOL017W ESC8 hom Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication
0.131 2.42E-14 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.125 3.83E-13 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.107 6.11E-10 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.104 1.46E-9 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.100 6.38E-9 YDR292C SRP101 het Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p
0.097 1.87E-8 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.092 1.02E-7 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.091 1.28E-7 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.089 2.61E-7 YLL061W MMP1 hom High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
0.087 5.02E-7 YML125C PGA3 het Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication
0.086 6.85E-7 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.084 1.17E-6 YDL032W_d YDL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene
0.080 4.09E-6 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.079 4.45E-6 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs