YOL108C / INO4

Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL108C / INO4

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:3.26|P-value:8.10E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:5.71|P-value:1.70E-8 ID:SGTC_384|Compound:k007-0144|FD-Score:3.20|P-value:9.70E-4 ID:SGTC_393|Compound:acivicin|FD-Score:4.05|P-value:4.44E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.02|P-value:5.05E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.73|P-value:1.53E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.62|P-value:2.33E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.27|P-value:7.84E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.19|P-value:2.57E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.44|P-value:4.38E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.83|P-value:1.54E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:4.82|P-value:1.60E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.69|P-value:1.80E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.37|P-value:5.49E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.42|P-value:4.76E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.92|P-value:1.01E-6 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.31|P-value:6.94E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-6.58|P-value:1.20E-10 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.75|P-value:1.46E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.36|P-value:1.23E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.30|P-value:7.08E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.40|P-value:4.99E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.32|P-value:7.03E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.92|P-value:8.05E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.51|P-value:3.45E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.61|P-value:2.61E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-4.54|P-value:6.09E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.76|P-value:1.39E-4 ID:SGTC_1791|Compound:st048313|FD-Score:5.55|P-value:4.08E-8 ID:SGTC_1949|Compound:st076024|FD-Score:4.14|P-value:3.15E-5 ID:SGTC_2023|Compound:5144124|FD-Score:5.30|P-value:1.55E-7 ID:SGTC_2024|Compound:5144227|FD-Score:4.23|P-value:2.14E-5 ID:SGTC_2033|Compound:5192550|FD-Score:4.09|P-value:3.81E-5 ID:SGTC_2034|Compound:5197015|FD-Score:-3.72|P-value:1.75E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:4.04|P-value:4.76E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.32|P-value:6.55E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-5.58|P-value:3.84E-8 ID:SGTC_2320|Compound:7373003|FD-Score:4.42|P-value:9.83E-6 ID:SGTC_2348|Compound:9022543|FD-Score:3.76|P-value:1.41E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.03|P-value:5.87E-7 ID:SGTC_2413|Compound:inermin|FD-Score:3.36|P-value:5.84E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:4.30|P-value:1.60E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.23|P-value:9.38E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.45|P-value:9.19E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.92|P-value:7.56E-5 ID:SGTC_2814|Compound:7977482|FD-Score:5.72|P-value:1.60E-8 ID:SGTC_2831|Compound:7999036|FD-Score:5.86|P-value:7.63E-9 ID:SGTC_2888|Compound:9058547|FD-Score:3.36|P-value:5.76E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.22|P-value:9.18E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.94|P-value:9.22E-7 ID:SGTC_3128|Compound:9127691|FD-Score:4.11|P-value:3.51E-5 ID:SGTC_3130|Compound:9127414|FD-Score:4.08|P-value:4.03E-5 ID:SGTC_3132|Compound:9126706|FD-Score:6.46|P-value:2.14E-10 ID:SGTC_3147|Compound:9097027|FD-Score:-4.09|P-value:4.17E-5 ID:SGTC_3149|Compound:9097855|FD-Score:4.64|P-value:3.66E-6 ID:SGTC_3151|Compound:9099821|FD-Score:6.54|P-value:1.33E-10 ID:SGTC_3152|Compound:9099253|FD-Score:11.00|P-value:1.13E-26 ID:SGTC_3189|Compound:9110682|FD-Score:-3.69|P-value:1.91E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-4.18|P-value:2.90E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.38|P-value:5.35E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.53|P-value:3.24E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.26|P-value:8.10E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:5.71|P-value:1.70E-8 ID:SGTC_384|Compound:k007-0144|FD-Score:3.20|P-value:9.70E-4 ID:SGTC_393|Compound:acivicin|FD-Score:4.05|P-value:4.44E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.02|P-value:5.05E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.73|P-value:1.53E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.62|P-value:2.33E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.27|P-value:7.84E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.19|P-value:2.57E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.44|P-value:4.38E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.83|P-value:1.54E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:4.82|P-value:1.60E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.69|P-value:1.80E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.37|P-value:5.49E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.42|P-value:4.76E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.92|P-value:1.01E-6 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.31|P-value:6.94E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-6.58|P-value:1.20E-10 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.75|P-value:1.46E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.36|P-value:1.23E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.30|P-value:7.08E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.40|P-value:4.99E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.32|P-value:7.03E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.92|P-value:8.05E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.51|P-value:3.45E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.61|P-value:2.61E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-4.54|P-value:6.09E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.76|P-value:1.39E-4 ID:SGTC_1791|Compound:st048313|FD-Score:5.55|P-value:4.08E-8 ID:SGTC_1949|Compound:st076024|FD-Score:4.14|P-value:3.15E-5 ID:SGTC_2023|Compound:5144124|FD-Score:5.30|P-value:1.55E-7 ID:SGTC_2024|Compound:5144227|FD-Score:4.23|P-value:2.14E-5 ID:SGTC_2033|Compound:5192550|FD-Score:4.09|P-value:3.81E-5 ID:SGTC_2034|Compound:5197015|FD-Score:-3.72|P-value:1.75E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:4.04|P-value:4.76E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.32|P-value:6.55E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-5.58|P-value:3.84E-8 ID:SGTC_2320|Compound:7373003|FD-Score:4.42|P-value:9.83E-6 ID:SGTC_2348|Compound:9022543|FD-Score:3.76|P-value:1.41E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.03|P-value:5.87E-7 ID:SGTC_2413|Compound:inermin|FD-Score:3.36|P-value:5.84E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:4.30|P-value:1.60E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.23|P-value:9.38E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.45|P-value:9.19E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.92|P-value:7.56E-5 ID:SGTC_2814|Compound:7977482|FD-Score:5.72|P-value:1.60E-8 ID:SGTC_2831|Compound:7999036|FD-Score:5.86|P-value:7.63E-9 ID:SGTC_2888|Compound:9058547|FD-Score:3.36|P-value:5.76E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.22|P-value:9.18E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.94|P-value:9.22E-7 ID:SGTC_3128|Compound:9127691|FD-Score:4.11|P-value:3.51E-5 ID:SGTC_3130|Compound:9127414|FD-Score:4.08|P-value:4.03E-5 ID:SGTC_3132|Compound:9126706|FD-Score:6.46|P-value:2.14E-10 ID:SGTC_3147|Compound:9097027|FD-Score:-4.09|P-value:4.17E-5 ID:SGTC_3149|Compound:9097855|FD-Score:4.64|P-value:3.66E-6 ID:SGTC_3151|Compound:9099821|FD-Score:6.54|P-value:1.33E-10 ID:SGTC_3152|Compound:9099253|FD-Score:11.00|P-value:1.13E-26 ID:SGTC_3189|Compound:9110682|FD-Score:-3.69|P-value:1.91E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-4.18|P-value:2.90E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.38|P-value:5.35E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.53|P-value:3.24E-4

Top fitness defect scores for YOL108C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3152 9099253 11.00 49.5 µM 1.13E-26 NEO1-PIK1 18 1.75E-28
2 SGTC_3151 9099821 6.54 49.5 µM 1.33E-10 1 3.06E-11
3 SGTC_3132 9126706 6.46 49.5 µM 2.14E-10 2 5.09E-11
4 SGTC_2831 7999036 5.86 19.5 µM 7.63E-9 5 2.34E-9
5 SGTC_2814 7977482 5.72 43.0 µM 1.60E-8 9 5.18E-9
6 SGTC_226 1,3-diallylurea 5.71 8.3 mM 1.70E-8 4 5.54E-9
7 SGTC_1791 st048313 5.55 56.1 µM 4.08E-8 2 1.41E-8
8 SGTC_2023 5144124 5.30 124.0 µM 1.55E-7 5 5.88E-8
9 SGTC_2397 5161689 5.03 200.0 µM 5.87E-7 14 2.46E-7
10 SGTC_3059 1327-0034 4.94 3.0 µM 9.22E-7 35 3.98E-7
11 SGTC_1036 k216-0215 4.92 33.5 µM 1.01E-6 mitochondrial response to ROS 26 4.38E-7
12 SGTC_794 k038-0031 4.83 316.0 µM 1.54E-6 ubiquinone biosynthesis & proteasome 83 6.89E-7
13 SGTC_804 1595-0054 4.82 20.9 µM 1.60E-6 sphingolipid biosynthesis & PDR1 20 7.16E-7
14 SGTC_3149 9097855 4.64 49.5 µM 3.66E-6 Golgi 12 1.74E-6
15 SGTC_2320 7373003 4.42 200.0 µM 9.83E-6 17 5.01E-6
16 SGTC_1250 0485-0349 4.36 40.2 µM 1.23E-5 21 6.37E-6
17 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 4.30 19.9 µM 1.60E-5 redox potentiating 7 8.43E-6
18 SGTC_2024 5144227 4.23 134.0 µM 2.14E-5 28 1.15E-5
19 SGTC_662 k832-1615 4.19 104.0 µM 2.57E-5 15 1.40E-5
20 SGTC_1949 st076024 4.14 69.1 µM 3.15E-5 19 1.74E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 6.64E-18 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.108 3.41E-10 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.107 5.40E-10 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.104 1.42E-9 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.104 1.78E-9 YKL182W FAS1 het Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
0.103 2.14E-9 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.102 3.31E-9 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.101 3.92E-9 YIL002C INP51 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth
0.100 6.91E-9 YJR126C VPS70 hom Protein of unknown function involved in vacuolar protein sorting
0.093 6.14E-8 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.091 1.13E-7 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.091 1.23E-7 YDR123C INO2 hom Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion
0.091 1.32E-7 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.091 1.50E-7 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.090 1.81E-7 YLR255C_d YLR255C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data