YOL109W / ZEO1

Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL109W / ZEO1

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:-3.75|P-value:1.14E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.57|P-value:2.29E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.62|P-value:1.86E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.78|P-value:1.08E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.86|P-value:8.13E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:4.77|P-value:1.54E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:3.61|P-value:2.08E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.64|P-value:1.86E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.00|P-value:4.49E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.83|P-value:8.87E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:5.84|P-value:5.60E-9 ID:SGTC_1725|Compound:st036284|FD-Score:3.61|P-value:2.11E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.46|P-value:3.58E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.22|P-value:8.28E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.50|P-value:3.05E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.17|P-value:9.11E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.38|P-value:4.73E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.41|P-value:4.33E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.65|P-value:2.55E-6 ID:SGTC_2287|Compound:7945887|FD-Score:3.70|P-value:1.49E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.67|P-value:2.46E-6 ID:SGTC_2332|Compound:7982454|FD-Score:3.93|P-value:6.04E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.40|P-value:4.44E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.43|P-value:5.27E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-5.20|P-value:1.62E-7 ID:SGTC_2866|Compound:9034245|FD-Score:-3.22|P-value:7.90E-4 ID:SGTC_2870|Compound:9038528|FD-Score:-3.45|P-value:3.45E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.25|P-value:7.46E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-3.29|P-value:6.04E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.04|P-value:3.92E-5 ID:SGTC_3327|Compound:9140648|FD-Score:-3.42|P-value:3.95E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.75|P-value:1.14E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.57|P-value:2.29E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.62|P-value:1.86E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.78|P-value:1.08E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.86|P-value:8.13E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:4.77|P-value:1.54E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:3.61|P-value:2.08E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.64|P-value:1.86E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.00|P-value:4.49E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.83|P-value:8.87E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:5.84|P-value:5.60E-9 ID:SGTC_1725|Compound:st036284|FD-Score:3.61|P-value:2.11E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.46|P-value:3.58E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.22|P-value:8.28E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.50|P-value:3.05E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.17|P-value:9.11E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.38|P-value:4.73E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.41|P-value:4.33E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.65|P-value:2.55E-6 ID:SGTC_2287|Compound:7945887|FD-Score:3.70|P-value:1.49E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.67|P-value:2.46E-6 ID:SGTC_2332|Compound:7982454|FD-Score:3.93|P-value:6.04E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.40|P-value:4.44E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.43|P-value:5.27E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-5.20|P-value:1.62E-7 ID:SGTC_2866|Compound:9034245|FD-Score:-3.22|P-value:7.90E-4 ID:SGTC_2870|Compound:9038528|FD-Score:-3.45|P-value:3.45E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.25|P-value:7.46E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-3.29|P-value:6.04E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.04|P-value:3.92E-5 ID:SGTC_3327|Compound:9140648|FD-Score:-3.42|P-value:3.95E-4

Top fitness defect scores for YOL109W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1588 farnesol 5.84 29.9 µM 5.60E-9 1 2.69E-9
2 SGTC_2582 agaric acid 5.43 100.0 µM 5.27E-8 redox potentiating 195 2.77E-8
3 SGTC_953 1188-0045 4.77 9.7 µM 1.54E-6 60S ribosome export 10 9.30E-7
4 SGTC_2330 7979373 4.67 200.0 µM 2.46E-6 60S ribosome export 19 1.52E-6
5 SGTC_3274 9138298 4.04 49.5 µM 3.92E-5 20 2.70E-5
6 SGTC_1248 0469-0687 4.00 58.6 µM 4.49E-5 27 3.11E-5
7 SGTC_2332 7982454 3.93 138.9 µM 6.04E-5 51 4.24E-5
8 SGTC_758 0868-0029 3.86 16.0 µM 8.13E-5 7 5.78E-5
9 SGTC_1582 3',3',6'-trihydroxyflavone 3.83 74.0 µM 8.87E-5 10 6.33E-5
10 SGTC_595 3909-8003 3.78 73.7 µM 1.08E-4 13 7.76E-5
11 SGTC_2287 7945887 3.70 168.8 µM 1.49E-4 10 1.08E-4
12 SGTC_1205 4161-2785 3.64 76.0 µM 1.86E-4 41 1.37E-4
13 SGTC_956 1185-0240 3.61 191.0 µM 2.08E-4 31 1.54E-4
14 SGTC_1725 st036284 3.61 20.6 µM 2.11E-4 40 1.56E-4
15 SGTC_1943 st076331 3.50 65.2 µM 3.05E-4 26 2.29E-4
16 SGTC_1863 st057641 3.46 20.1 µM 3.58E-4 25 2.70E-4
17 SGTC_2181 6316240 3.41 54.3 µM 4.33E-4 38 3.29E-4
18 SGTC_2363 9053361 3.40 176.0 µM 4.44E-4 Golgi 52 3.38E-4
19 SGTC_2100 5377183 3.38 190.0 µM 4.73E-4 60S ribosome export 26 3.61E-4
20 SGTC_3175 9106517 3.25 49.5 µM 7.46E-4 iron homeostasis 37 5.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.189 2.10E-28 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.164 1.31E-21 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.158 3.63E-20 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.147 1.29E-17 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.141 2.01E-16 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.137 1.36E-15 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.136 2.23E-15 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.134 5.80E-15 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.128 1.13E-13 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.127 1.44E-13 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.119 4.57E-12 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.118 6.71E-12 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.116 1.73E-11 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.114 4.12E-11 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.113 4.69E-11 YNL299W TRF5 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p