YOL111C / MDY2

Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL111C / MDY2

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:4.18|P-value:7.65E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.78|P-value:3.14E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.23|P-value:6.29E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.51|P-value:7.72E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:4.58|P-value:1.68E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:3.62|P-value:5.31E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.45|P-value:9.27E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.69|P-value:4.26E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:5.33|P-value:6.34E-7 ID:SGTC_1013|Compound:4112-3890|FD-Score:6.09|P-value:1.51E-8 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.56|P-value:1.77E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:-3.65|P-value:3.19E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.72|P-value:3.83E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:4.40|P-value:3.41E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:5.11|P-value:1.74E-6 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.44|P-value:9.39E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.33|P-value:9.07E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-5.59|P-value:1.03E-7 ID:SGTC_1605|Compound:st000082|FD-Score:3.95|P-value:1.78E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.44|P-value:9.58E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.45|P-value:2.71E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.87|P-value:2.30E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.43|P-value:9.93E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.46|P-value:8.89E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.72|P-value:3.82E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.84|P-value:2.54E-4 ID:SGTC_2006|Compound:4011487|FD-Score:5.43|P-value:4.09E-7 ID:SGTC_2061|Compound:5245884|FD-Score:-4.18|P-value:4.87E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.76|P-value:3.34E-4 ID:SGTC_2076|Compound:5212012|FD-Score:-4.06|P-value:7.48E-5 ID:SGTC_2077|Compound:5212015|FD-Score:3.81|P-value:2.90E-4 ID:SGTC_2080|Compound:5212524|FD-Score:4.50|P-value:2.24E-5 ID:SGTC_2145|Compound:5634607|FD-Score:3.42|P-value:0.00100 ID:SGTC_2245|Compound:6637752|FD-Score:3.82|P-value:2.72E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.04|P-value:1.27E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-4.88|P-value:2.71E-6 ID:SGTC_2414|Compound:st077232|FD-Score:3.62|P-value:5.40E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.76|P-value:7.87E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.48|P-value:2.44E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.55|P-value:6.75E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:-4.14|P-value:5.51E-5 ID:SGTC_2911|Compound:7942208|FD-Score:3.71|P-value:4.07E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.10|P-value:1.02E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-5.75|P-value:4.45E-8 ID:SGTC_2990|Compound:9074105|FD-Score:6.59|P-value:9.87E-10 ID:SGTC_2993|Compound:9054257|FD-Score:11.70|P-value:4.79E-27 ID:SGTC_3002|Compound:9075603|FD-Score:4.23|P-value:6.33E-5 ID:SGTC_3126|Compound:9127922|FD-Score:4.54|P-value:1.93E-5 ID:SGTC_47|Compound:0149-0135|FD-Score:4.18|P-value:7.65E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.78|P-value:3.14E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.23|P-value:6.29E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.51|P-value:7.72E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:4.58|P-value:1.68E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:3.62|P-value:5.31E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.45|P-value:9.27E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.69|P-value:4.26E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:5.33|P-value:6.34E-7 ID:SGTC_1013|Compound:4112-3890|FD-Score:6.09|P-value:1.51E-8 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.56|P-value:1.77E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:-3.65|P-value:3.19E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.72|P-value:3.83E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:4.40|P-value:3.41E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:5.11|P-value:1.74E-6 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.44|P-value:9.39E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.33|P-value:9.07E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-5.59|P-value:1.03E-7 ID:SGTC_1605|Compound:st000082|FD-Score:3.95|P-value:1.78E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.44|P-value:9.58E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.45|P-value:2.71E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.87|P-value:2.30E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.43|P-value:9.93E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.46|P-value:8.89E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.72|P-value:3.82E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.84|P-value:2.54E-4 ID:SGTC_2006|Compound:4011487|FD-Score:5.43|P-value:4.09E-7 ID:SGTC_2061|Compound:5245884|FD-Score:-4.18|P-value:4.87E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.76|P-value:3.34E-4 ID:SGTC_2076|Compound:5212012|FD-Score:-4.06|P-value:7.48E-5 ID:SGTC_2077|Compound:5212015|FD-Score:3.81|P-value:2.90E-4 ID:SGTC_2080|Compound:5212524|FD-Score:4.50|P-value:2.24E-5 ID:SGTC_2145|Compound:5634607|FD-Score:3.42|P-value:0.00100 ID:SGTC_2245|Compound:6637752|FD-Score:3.82|P-value:2.72E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.04|P-value:1.27E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-4.88|P-value:2.71E-6 ID:SGTC_2414|Compound:st077232|FD-Score:3.62|P-value:5.40E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.76|P-value:7.87E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.48|P-value:2.44E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.55|P-value:6.75E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:-4.14|P-value:5.51E-5 ID:SGTC_2911|Compound:7942208|FD-Score:3.71|P-value:4.07E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.10|P-value:1.02E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-5.75|P-value:4.45E-8 ID:SGTC_2990|Compound:9074105|FD-Score:6.59|P-value:9.87E-10 ID:SGTC_2993|Compound:9054257|FD-Score:11.70|P-value:4.79E-27 ID:SGTC_3002|Compound:9075603|FD-Score:4.23|P-value:6.33E-5 ID:SGTC_3126|Compound:9127922|FD-Score:4.54|P-value:1.93E-5

Top fitness defect scores for YOL111C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2993 9054257 11.70 71.4 µM 4.79E-27 fatty acid desaturase (OLE1) 6 5.73E-32
2 SGTC_2990 9074105 6.59 71.4 µM 9.87E-10 1 2.20E-11
3 SGTC_1013 4112-3890 6.09 241.0 µM 1.51E-8 TSC3-RPN4 8 5.63E-10
4 SGTC_2006 4011487 5.43 200.0 µM 4.09E-7 endomembrane recycling 52 2.86E-8
5 SGTC_850 0388-0143 5.33 75.9 µM 6.34E-7 2 4.82E-8
6 SGTC_1329 1447-1697 5.11 50.6 µM 1.74E-6 7 1.61E-7
7 SGTC_2420 aureobasidin a 4.76 50.0 nM 7.87E-6 23 9.67E-7
8 SGTC_347 4534-1311 4.58 26.2 µM 1.68E-5 RPP1 & pyrimidine depletion 6 2.38E-6
9 SGTC_1062 mesoridazine 4.56 14.2 µM 1.77E-5 9 2.53E-6
10 SGTC_3126 9127922 4.54 49.5 µM 1.93E-5 fatty acid desaturase (OLE1) 26 2.82E-6
11 SGTC_2080 5212524 4.50 12.4 µM 2.24E-5 copper-dependent oxidative stress 7 3.35E-6
12 SGTC_2454 5-benzylidenerhodanine 4.48 10.4 µM 2.44E-5 TRP & mitochondrial translation 23 3.72E-6
13 SGTC_1638 st008370 4.45 60.6 µM 2.71E-5 ergosterol biosynthesis 23 4.20E-6
14 SGTC_1292 0kpi-0043 4.40 232.0 µM 3.41E-5 6 5.53E-6
15 SGTC_160 3453-0671 4.23 289.7 µM 6.29E-5 31 1.15E-5
16 SGTC_3002 9075603 4.23 71.4 µM 6.33E-5 14 1.16E-5
17 SGTC_47 0149-0135 4.18 24.2 µM 7.65E-5 TSC3-RPN4 16 1.45E-5
18 SGTC_2949 9072542 4.10 2.2 µM 1.02E-4 TSC3-RPN4 34 2.05E-5
19 SGTC_2321 7390090 4.04 138.8 µM 1.27E-4 23 2.66E-5
20 SGTC_1605 st000082 3.95 49.1 µM 1.78E-4 60S ribosome export 14 3.95E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.27E-17 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.115 2.71E-11 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.094 4.71E-8 YPR113W PIS1 het Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
0.093 6.44E-8 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.093 7.87E-8 YNL203C_d YNL203C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.092 8.60E-8 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.090 1.66E-7 YNR068C_p YNR068C_p hom Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form
0.089 2.37E-7 YPR196W_p YPR196W_p hom Putative maltose-responsive transcription factor
0.088 3.13E-7 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.086 6.83E-7 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.083 1.68E-6 YOR206W NOC2 het Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
0.080 3.38E-6 YJL119C_d YJL119C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.43E-6 YMR055C BUB2 hom Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
0.079 4.92E-6 YOR372C NDD1 het Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes
0.078 6.33E-6 YPL140C MKK2 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication