YOL114C_p

Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL114C / YOL114C

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:-3.17|P-value:5.94E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.18|P-value:7.54E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.39|P-value:3.61E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.65|P-value:1.34E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:5.42|P-value:2.70E-8 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.23|P-value:6.43E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.17|P-value:7.87E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.43|P-value:4.58E-6 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.24|P-value:6.16E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.11|P-value:9.61E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.70|P-value:1.11E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.90|P-value:4.81E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.61|P-value:1.54E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.29|P-value:3.89E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.49|P-value:3.46E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.27|P-value:5.43E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.70|P-value:1.10E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.23|P-value:6.44E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.04|P-value:9.47E-4 ID:SGTC_1526|Compound:st051518|FD-Score:6.81|P-value:3.96E-12 ID:SGTC_1629|Compound:st005085|FD-Score:-3.63|P-value:1.06E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.99|P-value:3.32E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.52|P-value:2.17E-4 ID:SGTC_1650|Compound:st011916|FD-Score:-3.03|P-value:9.57E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.12|P-value:7.09E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.92|P-value:4.47E-5 ID:SGTC_1795|Compound:st049545|FD-Score:3.62|P-value:1.52E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-4.99|P-value:1.85E-7 ID:SGTC_1914|Compound:st062367|FD-Score:3.87|P-value:5.56E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-4.31|P-value:5.69E-6 ID:SGTC_1919|Compound:st067113|FD-Score:6.48|P-value:3.94E-11 ID:SGTC_1939|Compound:st074455|FD-Score:3.11|P-value:9.67E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.33|P-value:4.38E-4 ID:SGTC_2243|Compound:6634756|FD-Score:4.48|P-value:3.63E-6 ID:SGTC_2307|Compound:7538926|FD-Score:4.53|P-value:2.82E-6 ID:SGTC_2360|Compound:9040895|FD-Score:3.15|P-value:8.29E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.57|P-value:1.83E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.75|P-value:8.83E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.71|P-value:1.04E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.38|P-value:2.76E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.79|P-value:5.50E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.06|P-value:2.50E-5 ID:SGTC_2822|Compound:7994718|FD-Score:3.79|P-value:7.76E-5 ID:SGTC_2833|Compound:9001315|FD-Score:3.86|P-value:5.74E-5 ID:SGTC_2867|Compound:9039098|FD-Score:3.62|P-value:1.50E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.84|P-value:6.08E-5 ID:SGTC_3065|Compound:9113888|FD-Score:-3.32|P-value:3.50E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.28|P-value:5.40E-4 ID:SGTC_3289|Compound:9119912|FD-Score:4.62|P-value:1.90E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.17|P-value:5.94E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.18|P-value:7.54E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.39|P-value:3.61E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.65|P-value:1.34E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:5.42|P-value:2.70E-8 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.23|P-value:6.43E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.17|P-value:7.87E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.43|P-value:4.58E-6 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.24|P-value:6.16E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.11|P-value:9.61E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.70|P-value:1.11E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.90|P-value:4.81E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.61|P-value:1.54E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.29|P-value:3.89E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.49|P-value:3.46E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.27|P-value:5.43E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.70|P-value:1.10E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.23|P-value:6.44E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.04|P-value:9.47E-4 ID:SGTC_1526|Compound:st051518|FD-Score:6.81|P-value:3.96E-12 ID:SGTC_1629|Compound:st005085|FD-Score:-3.63|P-value:1.06E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.99|P-value:3.32E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.52|P-value:2.17E-4 ID:SGTC_1650|Compound:st011916|FD-Score:-3.03|P-value:9.57E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.12|P-value:7.09E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.92|P-value:4.47E-5 ID:SGTC_1795|Compound:st049545|FD-Score:3.62|P-value:1.52E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-4.99|P-value:1.85E-7 ID:SGTC_1914|Compound:st062367|FD-Score:3.87|P-value:5.56E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-4.31|P-value:5.69E-6 ID:SGTC_1919|Compound:st067113|FD-Score:6.48|P-value:3.94E-11 ID:SGTC_1939|Compound:st074455|FD-Score:3.11|P-value:9.67E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.33|P-value:4.38E-4 ID:SGTC_2243|Compound:6634756|FD-Score:4.48|P-value:3.63E-6 ID:SGTC_2307|Compound:7538926|FD-Score:4.53|P-value:2.82E-6 ID:SGTC_2360|Compound:9040895|FD-Score:3.15|P-value:8.29E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.57|P-value:1.83E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.75|P-value:8.83E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.71|P-value:1.04E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.38|P-value:2.76E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.79|P-value:5.50E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.06|P-value:2.50E-5 ID:SGTC_2822|Compound:7994718|FD-Score:3.79|P-value:7.76E-5 ID:SGTC_2833|Compound:9001315|FD-Score:3.86|P-value:5.74E-5 ID:SGTC_2867|Compound:9039098|FD-Score:3.62|P-value:1.50E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.84|P-value:6.08E-5 ID:SGTC_3065|Compound:9113888|FD-Score:-3.32|P-value:3.50E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.28|P-value:5.40E-4 ID:SGTC_3289|Compound:9119912|FD-Score:4.62|P-value:1.90E-6

Top fitness defect scores for YOL114C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1526 st051518 6.81 75.0 µM 3.96E-12 1 4.80E-12
2 SGTC_1919 st067113 6.48 52.3 µM 3.94E-11 TSC3-RPN4 8 4.63E-11
3 SGTC_697 0508-1955 5.42 564.0 µM 2.70E-8 7 2.92E-8
4 SGTC_3289 9119912 4.62 71.4 µM 1.90E-6 6 1.95E-6
5 SGTC_2307 7538926 4.53 6.3 µM 2.82E-6 23 2.89E-6
6 SGTC_1355 1499-0035 4.49 1.7 µM 3.46E-6 9 3.53E-6
7 SGTC_2243 6634756 4.48 200.0 µM 3.63E-6 12 3.71E-6
8 SGTC_1092 toremifene 4.43 6.3 µM 4.58E-6 14 4.66E-6
9 SGTC_2689 tacrolimus 4.06 100.0 µM 2.50E-5 43 2.50E-5
10 SGTC_1633 st005664 3.99 67.9 µM 3.32E-5 27 3.32E-5
11 SGTC_1677 st019204 3.92 53.9 µM 4.47E-5 16 4.45E-5
12 SGTC_1283 0922-0125 3.90 16.4 µM 4.81E-5 21 4.78E-5
13 SGTC_1914 st062367 3.87 72.6 µM 5.56E-5 21 5.52E-5
14 SGTC_2833 9001315 3.86 45.5 µM 5.74E-5 amide catabolism 57 5.70E-5
15 SGTC_2931 9014674 3.84 55.7 µM 6.08E-5 23 6.03E-5
16 SGTC_2822 7994718 3.79 71.4 µM 7.76E-5 24 7.68E-5
17 SGTC_2539 epi(13)torulosol 3.75 80.0 µM 8.83E-5 32 8.73E-5
18 SGTC_2573 2',4'-dihydroxychalcone 3.71 15.0 µM 1.04E-4 63 1.02E-4
19 SGTC_1397 3532-0190 3.70 20.1 µM 1.10E-4 9 1.09E-4
20 SGTC_1256 0570-0116 3.70 285.0 µM 1.11E-4 23 1.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.091 1.30E-7 YIR042C_p YIR042C_p hom Putative protein of unknown function; YIR042C is a non-essential gene
0.089 2.36E-7 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.085 8.72E-7 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.085 9.48E-7 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.082 1.75E-6 YBL054W TOD6 hom PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication
0.082 2.02E-6 YGR234W YHB1 hom Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.080 3.51E-6 YKL168C KKQ8 hom Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication
0.078 5.72E-6 YKL162C-A_d YKL162C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.077 8.38E-6 YLR173W_p YLR173W_p hom Putative protein of unknown function
0.075 1.43E-5 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.074 1.71E-5 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.073 2.12E-5 YPL233W NSL1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
0.073 2.50E-5 YPL219W PCL8 hom Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation
0.071 3.41E-5 YGL209W MIG2 hom Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication
0.071 3.67E-5 YPL177C CUP9 hom Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress