YOL115W / PAP2

Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL115W / PAP2

Click on Significant Values for Screen Details ID:SGTC_76|Compound:0433-0009|FD-Score:3.55|P-value:3.48E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.25|P-value:9.68E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.56|P-value:2.81E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-4.57|P-value:4.82E-6 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.69|P-value:2.12E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.81|P-value:1.10E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.25|P-value:8.07E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.42|P-value:5.52E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.87|P-value:1.06E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.71|P-value:1.98E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:4.61|P-value:5.04E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:3.33|P-value:7.39E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.21|P-value:2.76E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.60|P-value:2.86E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.98|P-value:7.13E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:4.91|P-value:1.31E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.58|P-value:3.08E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.36|P-value:1.52E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.63|P-value:4.69E-6 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.56|P-value:3.37E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.45|P-value:4.85E-4 ID:SGTC_1663|Compound:st014140|FD-Score:6.00|P-value:4.34E-9 ID:SGTC_1773|Compound:st048542|FD-Score:5.03|P-value:7.14E-7 ID:SGTC_1774|Compound:st048371|FD-Score:3.35|P-value:6.90E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.50|P-value:4.08E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.95|P-value:5.83E-9 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.67|P-value:2.72E-8 ID:SGTC_1792|Compound:st045773|FD-Score:3.61|P-value:2.85E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.32|P-value:1.79E-5 ID:SGTC_1807|Compound:st050092|FD-Score:4.15|P-value:3.66E-5 ID:SGTC_1821|Compound:st053465|FD-Score:4.90|P-value:1.36E-6 ID:SGTC_1868|Compound:st057644|FD-Score:3.41|P-value:5.56E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.81|P-value:1.36E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.19|P-value:9.69E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.95|P-value:8.02E-5 ID:SGTC_2092|Compound:5303694|FD-Score:3.69|P-value:2.10E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.57|P-value:3.26E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.99|P-value:6.80E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.30|P-value:7.99E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.33|P-value:1.72E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.62|P-value:2.67E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.02|P-value:6.12E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.48|P-value:4.42E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.62|P-value:2.19E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.38|P-value:5.14E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-4.12|P-value:3.32E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.92|P-value:8.84E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.67|P-value:2.28E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:8.72|P-value:2.89E-17 ID:SGTC_2784|Compound:7567673|FD-Score:3.89|P-value:1.01E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.31|P-value:1.83E-5 ID:SGTC_2824|Compound:7998404|FD-Score:3.54|P-value:3.54E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.24|P-value:2.49E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.85|P-value:1.17E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.82|P-value:1.94E-6 ID:SGTC_2867|Compound:9039098|FD-Score:3.34|P-value:7.08E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.67|P-value:2.25E-4 ID:SGTC_2893|Compound:9048488|FD-Score:6.32|P-value:6.79E-10 ID:SGTC_3045|Compound:9092950|FD-Score:3.81|P-value:1.33E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.25|P-value:9.55E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-4.36|P-value:1.19E-5 ID:SGTC_3113|Compound:9123498|FD-Score:3.71|P-value:1.95E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.67|P-value:2.24E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.55|P-value:3.48E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.25|P-value:9.68E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.56|P-value:2.81E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-4.57|P-value:4.82E-6 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.69|P-value:2.12E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.81|P-value:1.10E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.25|P-value:8.07E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.42|P-value:5.52E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.87|P-value:1.06E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.71|P-value:1.98E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:4.61|P-value:5.04E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:3.33|P-value:7.39E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.21|P-value:2.76E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.60|P-value:2.86E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.98|P-value:7.13E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:4.91|P-value:1.31E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.58|P-value:3.08E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.36|P-value:1.52E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.63|P-value:4.69E-6 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.56|P-value:3.37E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.45|P-value:4.85E-4 ID:SGTC_1663|Compound:st014140|FD-Score:6.00|P-value:4.34E-9 ID:SGTC_1773|Compound:st048542|FD-Score:5.03|P-value:7.14E-7 ID:SGTC_1774|Compound:st048371|FD-Score:3.35|P-value:6.90E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.50|P-value:4.08E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.95|P-value:5.83E-9 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.67|P-value:2.72E-8 ID:SGTC_1792|Compound:st045773|FD-Score:3.61|P-value:2.85E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.32|P-value:1.79E-5 ID:SGTC_1807|Compound:st050092|FD-Score:4.15|P-value:3.66E-5 ID:SGTC_1821|Compound:st053465|FD-Score:4.90|P-value:1.36E-6 ID:SGTC_1868|Compound:st057644|FD-Score:3.41|P-value:5.56E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.81|P-value:1.36E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.19|P-value:9.69E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.95|P-value:8.02E-5 ID:SGTC_2092|Compound:5303694|FD-Score:3.69|P-value:2.10E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.57|P-value:3.26E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.99|P-value:6.80E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.30|P-value:7.99E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.33|P-value:1.72E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.62|P-value:2.67E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.02|P-value:6.12E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.48|P-value:4.42E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.62|P-value:2.19E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.38|P-value:5.14E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-4.12|P-value:3.32E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.92|P-value:8.84E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.67|P-value:2.28E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:8.72|P-value:2.89E-17 ID:SGTC_2784|Compound:7567673|FD-Score:3.89|P-value:1.01E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.31|P-value:1.83E-5 ID:SGTC_2824|Compound:7998404|FD-Score:3.54|P-value:3.54E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.24|P-value:2.49E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.85|P-value:1.17E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.82|P-value:1.94E-6 ID:SGTC_2867|Compound:9039098|FD-Score:3.34|P-value:7.08E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.67|P-value:2.25E-4 ID:SGTC_2893|Compound:9048488|FD-Score:6.32|P-value:6.79E-10 ID:SGTC_3045|Compound:9092950|FD-Score:3.81|P-value:1.33E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.25|P-value:9.55E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-4.36|P-value:1.19E-5 ID:SGTC_3113|Compound:9123498|FD-Score:3.71|P-value:1.95E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.67|P-value:2.24E-4

Top fitness defect scores for YOL115W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2757 clomiphene 8.72 4.2 µM 2.89E-17 fatty acid desaturase (OLE1) 3 1.40E-18
2 SGTC_2893 9048488 6.32 26.0 µM 6.79E-10 fatty acid desaturase (OLE1) 3 1.30E-10
3 SGTC_1663 st014140 6.00 55.4 µM 4.34E-9 60S ribosome export 4 9.67E-10
4 SGTC_1785 bathophenanthroline 5.95 24.0 µM 5.83E-9 heme requiring 9 1.33E-9
5 SGTC_1789 tunicamycin 5.67 25.0 nM 2.72E-8 unfolded protein response 20 7.02E-9
6 SGTC_1773 st048542 5.03 73.6 µM 7.14E-7 27 2.40E-7
7 SGTC_872 0588-0139 4.91 234.0 µM 1.31E-6 14 4.62E-7
8 SGTC_1821 st053465 4.90 65.6 µM 1.36E-6 2 4.81E-7
9 SGTC_2849 9019321 4.82 13.0 µM 1.94E-6 18 7.06E-7
10 SGTC_1147 3809-1045 4.63 12.3 µM 4.69E-6 12 1.84E-6
11 SGTC_592 k241-0073 4.61 46.5 µM 5.04E-6 12 1.99E-6
12 SGTC_1074 carmofur 4.36 3.8 µM 1.52E-5 exosome 12 6.58E-6
13 SGTC_2489 cantharidin 4.33 73.4 µM 1.72E-5 cell wall signaling 33 7.51E-6
14 SGTC_1796 st049173 4.32 110.4 µM 1.79E-5 10 7.83E-6
15 SGTC_2823 7987624 4.31 58.4 µM 1.83E-5 20 8.02E-6
16 SGTC_2838 9002687 4.24 71.4 µM 2.49E-5 fatty acid desaturase (OLE1) 17 1.12E-5
17 SGTC_666 0272-0154 4.21 136.0 µM 2.76E-5 cell wall 46 1.25E-5
18 SGTC_1807 st050092 4.15 58.9 µM 3.66E-5 60S ribosome export 8 1.70E-5
19 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.02 92.6 µM 6.12E-5 26 2.95E-5
20 SGTC_2406 ethylparaben 3.99 405.7 µM 6.80E-5 37 3.31E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.90E-11 YAL048C GEM1 hom Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases
0.111 1.23E-10 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.103 1.87E-9 YOR258W HNT3 hom DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress
0.101 4.86E-9 YNR053C NOG2 het Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
0.099 8.63E-9 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.092 1.08E-7 YER006W NUG1 het GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
0.088 3.74E-7 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.088 3.70E-7 YER151C UBP3 hom Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.086 5.62E-7 YEL051W VMA8 hom Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
0.086 6.40E-7 YPR051W MAK3 hom Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
0.086 7.03E-7 YOR120W GCY1 hom Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication
0.085 7.63E-7 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.085 7.64E-7 YPR111W DBF20 hom Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs
0.084 1.01E-6 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.084 1.02E-6 YKL036C_d YKL036C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W