YOL116W / MSN1

Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL116W / MSN1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.40|P-value:3.55E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.51|P-value:2.48E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.70|P-value:1.22E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.31|P-value:5.22E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.36|P-value:4.27E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.40|P-value:3.49E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.94|P-value:4.57E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.74|P-value:1.04E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.62|P-value:1.64E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.32|P-value:8.94E-6 ID:SGTC_675|Compound:1309-0189|FD-Score:3.24|P-value:6.52E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.10|P-value:2.41E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.53|P-value:3.40E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:3.71|P-value:1.18E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.59|P-value:1.82E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.56|P-value:2.09E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.71|P-value:1.16E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.62|P-value:1.57E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:4.89|P-value:6.20E-7 ID:SGTC_898|Compound:1000-0849|FD-Score:4.00|P-value:3.68E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.57|P-value:1.98E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.46|P-value:3.04E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.56|P-value:2.10E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.08|P-value:2.57E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.35|P-value:4.53E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.97|P-value:4.12E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.34|P-value:8.45E-6 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.78|P-value:8.98E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.54|P-value:2.22E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:-3.61|P-value:1.63E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.51|P-value:2.51E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.46|P-value:3.01E-4 ID:SGTC_1793|Compound:st048256|FD-Score:3.21|P-value:7.33E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.38|P-value:3.99E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.22|P-value:6.72E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.88|P-value:6.03E-5 ID:SGTC_1961|Compound:st076550|FD-Score:3.68|P-value:1.32E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.58|P-value:2.78E-6 ID:SGTC_2009|Compound:4012297|FD-Score:-3.36|P-value:4.07E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.83|P-value:8.00E-7 ID:SGTC_2321|Compound:7390090|FD-Score:4.81|P-value:9.07E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.20|P-value:7.44E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.24|P-value:6.52E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.29|P-value:5.23E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:4.57|P-value:2.84E-6 ID:SGTC_2647|Compound:atorvastatin|FD-Score:-3.36|P-value:4.01E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:-3.12|P-value:9.44E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.22|P-value:7.04E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.46|P-value:2.78E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.93|P-value:4.88E-7 ID:SGTC_2683|Compound:piperine|FD-Score:4.06|P-value:2.81E-5 ID:SGTC_2993|Compound:9054257|FD-Score:4.40|P-value:6.28E-6 ID:SGTC_3000|Compound:9075062|FD-Score:3.36|P-value:4.33E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.83|P-value:6.78E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.40|P-value:3.55E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.51|P-value:2.48E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.70|P-value:1.22E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.31|P-value:5.22E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.36|P-value:4.27E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.40|P-value:3.49E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.94|P-value:4.57E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.74|P-value:1.04E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.62|P-value:1.64E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.32|P-value:8.94E-6 ID:SGTC_675|Compound:1309-0189|FD-Score:3.24|P-value:6.52E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.10|P-value:2.41E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.53|P-value:3.40E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:3.71|P-value:1.18E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.59|P-value:1.82E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.56|P-value:2.09E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.71|P-value:1.16E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.62|P-value:1.57E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:4.89|P-value:6.20E-7 ID:SGTC_898|Compound:1000-0849|FD-Score:4.00|P-value:3.68E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.57|P-value:1.98E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.46|P-value:3.04E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.56|P-value:2.10E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.08|P-value:2.57E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.35|P-value:4.53E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.97|P-value:4.12E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.34|P-value:8.45E-6 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.78|P-value:8.98E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.54|P-value:2.22E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:-3.61|P-value:1.63E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.51|P-value:2.51E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.46|P-value:3.01E-4 ID:SGTC_1793|Compound:st048256|FD-Score:3.21|P-value:7.33E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.38|P-value:3.99E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.22|P-value:6.72E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.88|P-value:6.03E-5 ID:SGTC_1961|Compound:st076550|FD-Score:3.68|P-value:1.32E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.58|P-value:2.78E-6 ID:SGTC_2009|Compound:4012297|FD-Score:-3.36|P-value:4.07E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.83|P-value:8.00E-7 ID:SGTC_2321|Compound:7390090|FD-Score:4.81|P-value:9.07E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.20|P-value:7.44E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.24|P-value:6.52E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.29|P-value:5.23E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:4.57|P-value:2.84E-6 ID:SGTC_2647|Compound:atorvastatin|FD-Score:-3.36|P-value:4.01E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:-3.12|P-value:9.44E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.22|P-value:7.04E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.46|P-value:2.78E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.93|P-value:4.88E-7 ID:SGTC_2683|Compound:piperine|FD-Score:4.06|P-value:2.81E-5 ID:SGTC_2993|Compound:9054257|FD-Score:4.40|P-value:6.28E-6 ID:SGTC_3000|Compound:9075062|FD-Score:3.36|P-value:4.33E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.83|P-value:6.78E-5

Top fitness defect scores for YOL116W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2668 2',4'-dihydroxychalcone 4.93 15.1 µM 4.88E-7 5 4.05E-7
2 SGTC_847 0342-0274 4.89 5.5 µM 6.20E-7 12 5.17E-7
3 SGTC_2105 5350118 4.83 200.0 µM 8.00E-7 11 6.69E-7
4 SGTC_2321 7390090 4.81 138.8 µM 9.07E-7 12 7.59E-7
5 SGTC_2003 4023581 4.58 200.0 µM 2.78E-6 cell wall signaling 24 2.36E-6
6 SGTC_2559 tetrahydrosappanone a trimethyl ether 4.57 100.0 µM 2.84E-6 3 2.41E-6
7 SGTC_733 4069-0007 4.53 56.1 µM 3.40E-6 ERAD & cell cycle 67 2.90E-6
8 SGTC_2993 9054257 4.40 71.4 µM 6.28E-6 fatty acid desaturase (OLE1) 32 5.39E-6
9 SGTC_1309 pyrazolanthrone 4.34 13.4 µM 8.45E-6 16 7.28E-6
10 SGTC_655 k060-0012 4.32 42.0 µM 8.94E-6 6 7.71E-6
11 SGTC_704 1310-0270 4.10 142.0 µM 2.41E-5 32 2.10E-5
12 SGTC_1164 k060-0068 4.08 93.7 µM 2.57E-5 21 2.24E-5
13 SGTC_2683 piperine 4.06 63.0 µM 2.81E-5 16 2.46E-5
14 SGTC_898 1000-0849 4.00 28.3 µM 3.68E-5 5 3.23E-5
15 SGTC_1210 3013-0140 3.97 750.0 nM 4.12E-5 5 3.62E-5
16 SGTC_591 4299-0174 3.94 154.0 µM 4.57E-5 10 4.02E-5
17 SGTC_1876 myriocin 3.88 605.0 nM 6.03E-5 35 5.33E-5
18 SGTC_1316 1272-0050 3.78 65.9 µM 8.98E-5 10 7.97E-5
19 SGTC_619 1652-1634 3.74 108.0 µM 1.04E-4 PDR1 24 9.26E-5
20 SGTC_838 0109-0203 3.71 71.4 µM 1.16E-4 20 1.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.99E-12 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.119 4.36E-12 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.112 9.47E-11 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.104 1.46E-9 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.102 3.44E-9 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.091 1.20E-7 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.090 1.83E-7 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.085 8.04E-7 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.082 2.28E-6 YDL101C DUN1 hom Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
0.081 2.31E-6 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.081 2.74E-6 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.081 2.73E-6 YGL103W RPL28 het Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
0.080 3.47E-6 YPR054W SMK1 hom Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
0.079 4.56E-6 YPL259C APM1 hom Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
0.077 7.17E-6 YGR007W ECT1 hom Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases