YOL117W / RRI2

Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL117W / RRI2

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.37|P-value:5.74E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:4.16|P-value:3.23E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:3.50|P-value:3.73E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:4.62|P-value:4.84E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:3.29|P-value:7.49E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.60|P-value:5.19E-6 ID:SGTC_264|Compound:promethazine|FD-Score:3.40|P-value:5.19E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.52|P-value:7.33E-6 ID:SGTC_444|Compound:curcumin|FD-Score:4.13|P-value:3.68E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:4.03|P-value:5.41E-5 ID:SGTC_462|Compound:ag-879|FD-Score:5.92|P-value:8.03E-9 ID:SGTC_524|Compound:r073-0010|FD-Score:3.35|P-value:6.25E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:4.11|P-value:3.92E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:3.75|P-value:1.53E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.76|P-value:1.49E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:5.71|P-value:2.42E-8 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.70|P-value:3.23E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.82|P-value:2.14E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.52|P-value:3.47E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.33|P-value:6.55E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.22|P-value:9.35E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.23|P-value:9.08E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:6.18|P-value:1.84E-9 ID:SGTC_992|Compound:3909-8734|FD-Score:3.77|P-value:1.46E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.29|P-value:7.58E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.98|P-value:1.21E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.41|P-value:5.05E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.38|P-value:9.44E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.07|P-value:8.45E-5 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.58|P-value:2.84E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.54|P-value:3.23E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.40|P-value:5.25E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.82|P-value:2.12E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:4.59|P-value:5.42E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.82|P-value:1.21E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.44|P-value:4.51E-4 ID:SGTC_1739|Compound:st037196|FD-Score:5.51|P-value:7.20E-8 ID:SGTC_1750|Compound:st081859|FD-Score:4.53|P-value:6.93E-6 ID:SGTC_1762|Compound:st045503|FD-Score:4.74|P-value:2.85E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.37|P-value:5.83E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.55|P-value:3.13E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.30|P-value:1.86E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.95|P-value:7.26E-5 ID:SGTC_2002|Compound:4023503|FD-Score:5.04|P-value:7.16E-7 ID:SGTC_2005|Compound:4024620|FD-Score:4.58|P-value:5.62E-6 ID:SGTC_2053|Compound:5265679|FD-Score:3.29|P-value:7.41E-4 ID:SGTC_2071|Compound:5230951|FD-Score:4.46|P-value:9.44E-6 ID:SGTC_2274|Compound:7947094|FD-Score:3.26|P-value:8.33E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.65|P-value:3.82E-4 ID:SGTC_2391|Compound:6285546|FD-Score:5.01|P-value:8.24E-7 ID:SGTC_2414|Compound:st077232|FD-Score:-6.19|P-value:4.27E-9 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.22|P-value:9.50E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.56|P-value:3.04E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.42|P-value:4.88E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.45|P-value:4.49E-4 ID:SGTC_2709|Compound:st078560|FD-Score:4.07|P-value:4.59E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.24|P-value:8.89E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.23|P-value:9.20E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.52|P-value:3.47E-4 ID:SGTC_3014|Compound:9081533|FD-Score:-3.86|P-value:1.87E-4 ID:SGTC_3017|Compound:9080681|FD-Score:5.31|P-value:1.97E-7 ID:SGTC_3047|Compound:9092122|FD-Score:-4.21|P-value:5.07E-5 ID:SGTC_3058|Compound:9093861|FD-Score:3.35|P-value:6.25E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.37|P-value:5.74E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:4.16|P-value:3.23E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:3.50|P-value:3.73E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:4.62|P-value:4.84E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:3.29|P-value:7.49E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.60|P-value:5.19E-6 ID:SGTC_264|Compound:promethazine|FD-Score:3.40|P-value:5.19E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.52|P-value:7.33E-6 ID:SGTC_444|Compound:curcumin|FD-Score:4.13|P-value:3.68E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:4.03|P-value:5.41E-5 ID:SGTC_462|Compound:ag-879|FD-Score:5.92|P-value:8.03E-9 ID:SGTC_524|Compound:r073-0010|FD-Score:3.35|P-value:6.25E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:4.11|P-value:3.92E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:3.75|P-value:1.53E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.76|P-value:1.49E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:5.71|P-value:2.42E-8 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.70|P-value:3.23E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.82|P-value:2.14E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.52|P-value:3.47E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.33|P-value:6.55E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.22|P-value:9.35E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.23|P-value:9.08E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:6.18|P-value:1.84E-9 ID:SGTC_992|Compound:3909-8734|FD-Score:3.77|P-value:1.46E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.29|P-value:7.58E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.98|P-value:1.21E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.41|P-value:5.05E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.38|P-value:9.44E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.07|P-value:8.45E-5 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.58|P-value:2.84E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.54|P-value:3.23E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.40|P-value:5.25E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.82|P-value:2.12E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:4.59|P-value:5.42E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.82|P-value:1.21E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.44|P-value:4.51E-4 ID:SGTC_1739|Compound:st037196|FD-Score:5.51|P-value:7.20E-8 ID:SGTC_1750|Compound:st081859|FD-Score:4.53|P-value:6.93E-6 ID:SGTC_1762|Compound:st045503|FD-Score:4.74|P-value:2.85E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.37|P-value:5.83E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.55|P-value:3.13E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.30|P-value:1.86E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.95|P-value:7.26E-5 ID:SGTC_2002|Compound:4023503|FD-Score:5.04|P-value:7.16E-7 ID:SGTC_2005|Compound:4024620|FD-Score:4.58|P-value:5.62E-6 ID:SGTC_2053|Compound:5265679|FD-Score:3.29|P-value:7.41E-4 ID:SGTC_2071|Compound:5230951|FD-Score:4.46|P-value:9.44E-6 ID:SGTC_2274|Compound:7947094|FD-Score:3.26|P-value:8.33E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.65|P-value:3.82E-4 ID:SGTC_2391|Compound:6285546|FD-Score:5.01|P-value:8.24E-7 ID:SGTC_2414|Compound:st077232|FD-Score:-6.19|P-value:4.27E-9 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.22|P-value:9.50E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.56|P-value:3.04E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.42|P-value:4.88E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.45|P-value:4.49E-4 ID:SGTC_2709|Compound:st078560|FD-Score:4.07|P-value:4.59E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.24|P-value:8.89E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.23|P-value:9.20E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.52|P-value:3.47E-4 ID:SGTC_3014|Compound:9081533|FD-Score:-3.86|P-value:1.87E-4 ID:SGTC_3017|Compound:9080681|FD-Score:5.31|P-value:1.97E-7 ID:SGTC_3047|Compound:9092122|FD-Score:-4.21|P-value:5.07E-5 ID:SGTC_3058|Compound:9093861|FD-Score:3.35|P-value:6.25E-4

Top fitness defect scores for YOL117W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_967 1306-0166 6.18 352.0 µM 1.84E-9 3 3.15E-10
2 SGTC_462 ag-879 5.92 158.0 µM 8.03E-9 4 1.62E-9
3 SGTC_686 1319-0111 5.71 510.0 µM 2.42E-8 60S ribosome export 2 5.51E-9
4 SGTC_1739 st037196 5.51 92.5 µM 7.20E-8 3 1.84E-8
5 SGTC_3017 9080681 5.31 49.5 µM 1.97E-7 4 5.61E-8
6 SGTC_2002 4023503 5.04 131.0 µM 7.16E-7 mitochondrial processes 13 2.35E-7
7 SGTC_2391 6285546 5.01 200.0 µM 8.24E-7 2 2.74E-7
8 SGTC_1762 st045503 4.74 25.5 µM 2.85E-6 13 1.08E-6
9 SGTC_125 0133-0007 4.62 11.8 µM 4.84E-6 DNA intercalators 1 1.94E-6
10 SGTC_258 haloperidol 4.60 50.8 µM 5.19E-6 fatty acid desaturase (OLE1) 20 2.09E-6
11 SGTC_1444 4112-3581 4.59 28.0 µM 5.42E-6 1 2.20E-6
12 SGTC_2005 4024620 4.58 188.0 µM 5.62E-6 11 2.29E-6
13 SGTC_1750 st081859 4.53 2.4 µM 6.93E-6 endomembrane recycling 151 2.88E-6
14 SGTC_265 mycophenolic acid 4.52 32.9 µM 7.33E-6 RPP1 & pyrimidine depletion 8 3.07E-6
15 SGTC_2071 5230951 4.46 39.9 µM 9.44E-6 TSC3-RPN4 14 4.05E-6
16 SGTC_1869 3',7'-dimethoxyflavone 4.30 40.3 µM 1.86E-5 18 8.59E-6
17 SGTC_97 0535-0701 4.16 19.1 µM 3.23E-5 60S ribosome export 11 1.58E-5
18 SGTC_444 curcumin 4.13 90.4 µM 3.68E-5 iron homeostasis 23 1.82E-5
19 SGTC_566 0958-0068 4.11 16.5 µM 3.92E-5 RSC & ERG11 17 1.95E-5
20 SGTC_2709 st078560 4.07 56.0 µM 4.59E-5 10 2.32E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.14E-9 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.098 1.27E-8 YOR192C THI72 hom Transporter of thiamine or related compound; shares sequence similarity with Thi7p
0.092 1.03E-7 YPR153W YPR153W hom Putative protein of unknown function
0.086 5.55E-7 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.085 7.37E-7 YMR230W RPS10B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication
0.083 1.54E-6 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.076 1.02E-5 YOR053W_d YOR053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C
0.075 1.26E-5 YKL191W DPH2 hom Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
0.074 1.63E-5 YLR335W NUP2 hom Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
0.074 1.68E-5 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.072 2.78E-5 YOL052C SPE2 hom S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
0.072 2.94E-5 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.070 4.65E-5 YMR251W GTO3 hom Omega class glutathione transferase; putative cytosolic localization
0.070 4.81E-5 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.070 5.21E-5 YNR019W ARE2 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication