YOL118C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL118C / YOL118C

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:3.48|P-value:3.80E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:-3.55|P-value:2.17E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.65|P-value:3.24E-6 ID:SGTC_94|Compound:0334-0113|FD-Score:4.19|P-value:2.49E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.76|P-value:1.38E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.33|P-value:4.83E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.52|P-value:2.45E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.24|P-value:8.69E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.47|P-value:2.89E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.36|P-value:5.87E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.98|P-value:6.66E-7 ID:SGTC_780|Compound:0109-0199|FD-Score:-4.02|P-value:3.52E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:7.14|P-value:1.87E-12 ID:SGTC_790|Compound:1575-0012|FD-Score:3.50|P-value:3.60E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.44|P-value:4.41E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:4.04|P-value:4.56E-5 ID:SGTC_1611|Compound:st001856|FD-Score:-4.66|P-value:2.05E-6 ID:SGTC_1629|Compound:st005085|FD-Score:3.29|P-value:7.39E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.45|P-value:3.09E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.83|P-value:7.33E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.75|P-value:1.44E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-4.06|P-value:3.00E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.39|P-value:3.83E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.85|P-value:9.64E-5 ID:SGTC_1957|Compound:st077035|FD-Score:-3.86|P-value:6.73E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-3.49|P-value:2.67E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.50|P-value:6.32E-6 ID:SGTC_2008|Compound:4012253|FD-Score:3.23|P-value:9.09E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.47|P-value:2.95E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.47|P-value:3.93E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.28|P-value:1.69E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.58|P-value:4.41E-6 ID:SGTC_2602|Compound:kawain|FD-Score:-4.34|P-value:8.71E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.31|P-value:6.88E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:-3.50|P-value:2.64E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.22|P-value:9.47E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.49|P-value:6.86E-6 ID:SGTC_2712|Compound:st079126|FD-Score:3.47|P-value:3.93E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.24|P-value:8.63E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.37|P-value:5.60E-4 ID:SGTC_2828|Compound:7998861|FD-Score:-3.17|P-value:8.41E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.30|P-value:5.34E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.22|P-value:9.25E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-5.08|P-value:2.65E-7 ID:SGTC_2907|Compound:7721985|FD-Score:-3.20|P-value:7.43E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.50|P-value:6.39E-6 ID:SGTC_2963|Compound:9082507|FD-Score:3.52|P-value:3.29E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.57|P-value:2.80E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.93|P-value:5.05E-5 ID:SGTC_3138|Compound:9097216|FD-Score:3.29|P-value:7.41E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.86|P-value:9.25E-5 ID:SGTC_13|Compound:0199-0087|FD-Score:3.48|P-value:3.80E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:-3.55|P-value:2.17E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.65|P-value:3.24E-6 ID:SGTC_94|Compound:0334-0113|FD-Score:4.19|P-value:2.49E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.76|P-value:1.38E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.33|P-value:4.83E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.52|P-value:2.45E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.24|P-value:8.69E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.47|P-value:2.89E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.36|P-value:5.87E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.98|P-value:6.66E-7 ID:SGTC_780|Compound:0109-0199|FD-Score:-4.02|P-value:3.52E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:7.14|P-value:1.87E-12 ID:SGTC_790|Compound:1575-0012|FD-Score:3.50|P-value:3.60E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.44|P-value:4.41E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:4.04|P-value:4.56E-5 ID:SGTC_1611|Compound:st001856|FD-Score:-4.66|P-value:2.05E-6 ID:SGTC_1629|Compound:st005085|FD-Score:3.29|P-value:7.39E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.45|P-value:3.09E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.83|P-value:7.33E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.75|P-value:1.44E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-4.06|P-value:3.00E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.39|P-value:3.83E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.85|P-value:9.64E-5 ID:SGTC_1957|Compound:st077035|FD-Score:-3.86|P-value:6.73E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-3.49|P-value:2.67E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.50|P-value:6.32E-6 ID:SGTC_2008|Compound:4012253|FD-Score:3.23|P-value:9.09E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.47|P-value:2.95E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.47|P-value:3.93E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.28|P-value:1.69E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.58|P-value:4.41E-6 ID:SGTC_2602|Compound:kawain|FD-Score:-4.34|P-value:8.71E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.31|P-value:6.88E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:-3.50|P-value:2.64E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.22|P-value:9.47E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.49|P-value:6.86E-6 ID:SGTC_2712|Compound:st079126|FD-Score:3.47|P-value:3.93E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.24|P-value:8.63E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.37|P-value:5.60E-4 ID:SGTC_2828|Compound:7998861|FD-Score:-3.17|P-value:8.41E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.30|P-value:5.34E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.22|P-value:9.25E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-5.08|P-value:2.65E-7 ID:SGTC_2907|Compound:7721985|FD-Score:-3.20|P-value:7.43E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.50|P-value:6.39E-6 ID:SGTC_2963|Compound:9082507|FD-Score:3.52|P-value:3.29E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.57|P-value:2.80E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.93|P-value:5.05E-5 ID:SGTC_3138|Compound:9097216|FD-Score:3.29|P-value:7.41E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.86|P-value:9.25E-5

Top fitness defect scores for YOL118C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_786 4544-0069 7.14 423.0 µM 1.87E-12 4 4.69E-13
2 SGTC_744 1594-0068 4.98 283.0 µM 6.66E-7 amide catabolism 10 3.14E-7
3 SGTC_52 0329-0193 4.65 875.0 nM 3.24E-6 TSC3-RPN4 19 1.66E-6
4 SGTC_2589 lobaric acid 4.58 100.0 µM 4.41E-6 16 2.29E-6
5 SGTC_2003 4023581 4.50 200.0 µM 6.32E-6 cell wall signaling 25 3.34E-6
6 SGTC_2958 9077254 4.50 16.7 µM 6.39E-6 18 3.38E-6
7 SGTC_2675 theaflavin digallate 4.49 100.0 µM 6.86E-6 iron homeostasis 22 3.64E-6
8 SGTC_2588 indole-3-carbinol 4.28 100.0 µM 1.69E-5 35 9.37E-6
9 SGTC_94 0334-0113 4.19 514.8 µM 2.49E-5 16 1.41E-5
10 SGTC_1307 1187-1599 4.04 12.2 µM 4.56E-5 PDR1 11 2.67E-5
11 SGTC_3140 9094243 3.86 49.5 µM 9.25E-5 26 5.61E-5
12 SGTC_1910 st062352 3.85 60.4 µM 9.64E-5 40 5.86E-5
13 SGTC_105 0111-0055 3.76 734.8 µM 1.38E-4 7 8.54E-5
14 SGTC_1803 st050068 3.75 52.4 µM 1.44E-4 NEO1-PIK1 199 8.92E-5
15 SGTC_3072 9116419 3.57 49.5 µM 2.80E-4 ERG2 29 1.80E-4
16 SGTC_2963 9082507 3.52 9.0 µM 3.29E-4 38 2.13E-4
17 SGTC_790 1575-0012 3.50 79.1 µM 3.60E-4 TSC3-RPN4 44 2.34E-4
18 SGTC_13 0199-0087 3.48 65.0 µM 3.80E-4 ERG2 15 2.48E-4
19 SGTC_2712 st079126 3.47 47.7 µM 3.93E-4 31 2.57E-4
20 SGTC_2296 7971656 3.47 126.5 µM 3.93E-4 62 2.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.05E-11 YDL010W GRX6 hom Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
0.089 2.32E-7 YDL101C DUN1 hom Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
0.084 9.82E-7 YBR022W POA1 hom Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
0.084 1.28E-6 YPL208W RKM1 hom SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
0.083 1.50E-6 YOR328W PDR10 hom ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
0.082 2.03E-6 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.082 1.94E-6 YPL137C GIP3 hom Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication
0.081 2.33E-6 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.080 3.29E-6 YCR079W PTC6 hom Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
0.078 5.53E-6 YLR290C_p YLR290C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene
0.075 1.47E-5 YLR208W SEC13 het Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress
0.070 4.44E-5 YLR002C NOC3 het Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing
0.069 6.90E-5 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.067 1.05E-4 YLR052W IES3 hom Subunit of the INO80 chromatin remodeling complex
0.066 1.39E-4 YKR091W SRL3 hom Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate