YOL119C / MCH4

Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL119C / MCH4

Click on Significant Values for Screen Details ID:SGTC_175|Compound:3793-3120|FD-Score:-3.11|P-value:6.27E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.04|P-value:6.04E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.23|P-value:3.88E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.09|P-value:6.75E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.25|P-value:2.67E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.63|P-value:5.59E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.68|P-value:4.62E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:-3.41|P-value:1.93E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.12|P-value:5.94E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.87|P-value:1.99E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.35|P-value:1.94E-6 ID:SGTC_1145|Compound:3546-0597|FD-Score:2.94|P-value:8.61E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:4.13|P-value:5.85E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.52|P-value:9.09E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.10|P-value:4.80E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.29|P-value:2.33E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:4.37|P-value:1.77E-6 ID:SGTC_1350|Compound:1495-0454|FD-Score:6.67|P-value:8.11E-13 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.73|P-value:5.18E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.17|P-value:3.72E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:4.19|P-value:4.25E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.45|P-value:1.20E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.96|P-value:7.96E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.07|P-value:5.35E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.50|P-value:1.37E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.44|P-value:1.25E-4 ID:SGTC_1722|Compound:st034304|FD-Score:6.37|P-value:7.99E-12 ID:SGTC_1743|Compound:st037606|FD-Score:3.14|P-value:4.19E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.43|P-value:1.31E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.17|P-value:3.63E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.52|P-value:9.21E-5 ID:SGTC_2020|Compound:4017018|FD-Score:-3.07|P-value:7.25E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.01|P-value:6.61E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.76|P-value:4.47E-5 ID:SGTC_2133|Compound:5320837|FD-Score:7.07|P-value:3.81E-14 ID:SGTC_2150|Compound:5556613|FD-Score:-3.84|P-value:3.24E-5 ID:SGTC_2164|Compound:5685496|FD-Score:-3.37|P-value:2.25E-4 ID:SGTC_2185|Compound:6113692|FD-Score:2.90|P-value:9.76E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.28|P-value:2.41E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.22|P-value:2.99E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.48|P-value:1.50E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.06|P-value:5.46E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:4.39|P-value:1.59E-6 ID:SGTC_2824|Compound:7998404|FD-Score:4.59|P-value:5.50E-7 ID:SGTC_2831|Compound:7999036|FD-Score:2.94|P-value:8.74E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.93|P-value:1.47E-5 ID:SGTC_2894|Compound:9048625|FD-Score:-3.54|P-value:1.14E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.77|P-value:3.01E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-4.06|P-value:1.17E-5 ID:SGTC_2996|Compound:9066192|FD-Score:-4.01|P-value:1.50E-5 ID:SGTC_3055|Compound:9094636|FD-Score:3.36|P-value:1.73E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-3.30|P-value:3.00E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.81|P-value:2.55E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.11|P-value:6.27E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.04|P-value:6.04E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.23|P-value:3.88E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.09|P-value:6.75E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.25|P-value:2.67E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.63|P-value:5.59E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.68|P-value:4.62E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:-3.41|P-value:1.93E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.12|P-value:5.94E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.87|P-value:1.99E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.35|P-value:1.94E-6 ID:SGTC_1145|Compound:3546-0597|FD-Score:2.94|P-value:8.61E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:4.13|P-value:5.85E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.52|P-value:9.09E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.10|P-value:4.80E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.29|P-value:2.33E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:4.37|P-value:1.77E-6 ID:SGTC_1350|Compound:1495-0454|FD-Score:6.67|P-value:8.11E-13 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.73|P-value:5.18E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.17|P-value:3.72E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:4.19|P-value:4.25E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.45|P-value:1.20E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.96|P-value:7.96E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.07|P-value:5.35E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.50|P-value:1.37E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.44|P-value:1.25E-4 ID:SGTC_1722|Compound:st034304|FD-Score:6.37|P-value:7.99E-12 ID:SGTC_1743|Compound:st037606|FD-Score:3.14|P-value:4.19E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.43|P-value:1.31E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.17|P-value:3.63E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.52|P-value:9.21E-5 ID:SGTC_2020|Compound:4017018|FD-Score:-3.07|P-value:7.25E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.01|P-value:6.61E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.76|P-value:4.47E-5 ID:SGTC_2133|Compound:5320837|FD-Score:7.07|P-value:3.81E-14 ID:SGTC_2150|Compound:5556613|FD-Score:-3.84|P-value:3.24E-5 ID:SGTC_2164|Compound:5685496|FD-Score:-3.37|P-value:2.25E-4 ID:SGTC_2185|Compound:6113692|FD-Score:2.90|P-value:9.76E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.28|P-value:2.41E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.22|P-value:2.99E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.48|P-value:1.50E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.06|P-value:5.46E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:4.39|P-value:1.59E-6 ID:SGTC_2824|Compound:7998404|FD-Score:4.59|P-value:5.50E-7 ID:SGTC_2831|Compound:7999036|FD-Score:2.94|P-value:8.74E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.93|P-value:1.47E-5 ID:SGTC_2894|Compound:9048625|FD-Score:-3.54|P-value:1.14E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.77|P-value:3.01E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-4.06|P-value:1.17E-5 ID:SGTC_2996|Compound:9066192|FD-Score:-4.01|P-value:1.50E-5 ID:SGTC_3055|Compound:9094636|FD-Score:3.36|P-value:1.73E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-3.30|P-value:3.00E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.81|P-value:2.55E-5

Top fitness defect scores for YOL119C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2133 5320837 7.07 200.0 µM 3.81E-14 ERG2 2 7.90E-13
2 SGTC_1350 1495-0454 6.67 146.0 µM 8.11E-13 3 1.24E-11
3 SGTC_1722 st034304 6.37 3.6 µM 7.99E-12 mitochondrial processes 4 9.71E-11
4 SGTC_2824 7998404 4.59 52.0 µM 5.50E-7 19 2.19E-6
5 SGTC_2769 toremifene 4.39 3.7 µM 1.59E-6 14 5.69E-6
6 SGTC_1349 flufenamic acid 4.37 69.0 µM 1.77E-6 7 6.27E-6
7 SGTC_1116 jasmonic acid 4.35 1.6 µM 1.94E-6 13 6.81E-6
8 SGTC_1393 3470-5649 4.19 58.2 µM 4.25E-6 60S ribosome export 14 1.38E-5
9 SGTC_1220 1838-0075 4.13 193.0 µM 5.85E-6 8 1.84E-5
10 SGTC_1010 4112-3296 4.12 15.2 µM 5.94E-6 14 1.86E-5
11 SGTC_2842 9000675 3.93 19.5 µM 1.47E-5 21 4.22E-5
12 SGTC_1083 didemethylchlorpromazine sulfoxide 3.87 707.4 nM 1.99E-5 redox potentiating 88 5.53E-5
13 SGTC_3279 9140807 3.81 49.5 µM 2.55E-5 19 6.91E-5
14 SGTC_2943 9068529 3.77 45.3 µM 3.01E-5 22 8.02E-5
15 SGTC_966 1300-0360 3.68 30.2 µM 4.62E-5 heme requiring 29 1.18E-4
16 SGTC_762 1165-0429 3.63 115.0 µM 5.59E-5 TSC3-RPN4 28 1.40E-4
17 SGTC_1226 3909-7979 3.52 35.4 µM 9.09E-5 54 2.17E-4
18 SGTC_2019 4016004 3.52 108.0 µM 9.21E-5 45 2.20E-4
19 SGTC_1395 3486-0190 3.45 4.3 µM 1.20E-4 27 2.78E-4
20 SGTC_1679 4130-1276 3.44 6.7 µM 1.25E-4 Golgi 94 2.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.90E-16 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.123 7.61E-13 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.113 6.46E-11 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 3.17E-10 YPL038W-A_p YPL038W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.106 6.54E-10 YDL103C QRI1 het UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress
0.106 8.00E-10 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.089 2.34E-7 YGL065C ALG2 het Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
0.085 8.05E-7 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.082 1.90E-6 YHL030W ECM29 hom Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress
0.081 2.68E-6 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.081 2.80E-6 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.081 2.96E-6 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.080 3.79E-6 YPR188C MLC2 hom Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring
0.077 7.48E-6 YGL069C_d YGL069C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance
0.077 8.68E-6 YKL105C SEG2 hom Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes