Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
Zygosity: Homozygous strain
fixedexpanded
![]() ![]() Click on Significant Values for Screen Details |
Top fitness defect scores for YOL122C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.152 | 9.32E-19 | YGL130W | CEG1 | het | Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide |
0.133 | 8.32E-15 | YBR235W | VHC1 | hom | Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family |
0.133 | 9.52E-15 | YOL032W | OPI10 | hom | Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress |
0.127 | 1.71E-13 | YGL168W | HUR1 | hom | Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene |
0.125 | 4.39E-13 | YLR296W_d | YLR296W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.124 | 4.74E-13 | YER111C | SWI4 | hom | DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p |
0.110 | 1.92E-10 | YJR107W_p | YJR107W_p | hom | Putative lipase |
0.099 | 7.70E-9 | YAL016C-B_d | YAL016C-B_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.096 | 2.70E-8 | YGR192C | TDH3 | hom | Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication |
0.094 | 5.10E-8 | YDL164C | CDC9 | het | DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination |
0.094 | 5.48E-8 | YBR183W | YPC1 | hom | Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication |
0.090 | 1.88E-7 | YOR021C | SFM1 | hom | SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism |
0.090 | 2.03E-7 | YER002W | NOP16 | hom | Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis |
0.088 | 3.36E-7 | YLR327C | TMA10 | hom | Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress |
0.088 | 3.63E-7 | YDR225W | HTA1 | hom | Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p |