YOL122C / SMF1

Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL122C / SMF1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:5.12|P-value:4.53E-8 ID:SGTC_29|Compound:0299-0004|FD-Score:5.21|P-value:2.64E-8 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.62|P-value:8.69E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.30|P-value:3.03E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.22|P-value:3.85E-4 ID:SGTC_459|Compound:nigericin|FD-Score:7.22|P-value:2.46E-14 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.02|P-value:8.03E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.57|P-value:9.58E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.44|P-value:1.63E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:5.56|P-value:3.26E-9 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.08|P-value:6.47E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.21|P-value:3.94E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.66|P-value:6.42E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.18|P-value:4.47E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.62|P-value:7.55E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.24|P-value:3.52E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:2.98|P-value:8.97E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.90|P-value:2.24E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:2.97|P-value:9.37E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.03|P-value:7.65E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.90|P-value:2.33E-5 ID:SGTC_1961|Compound:st076550|FD-Score:4.26|P-value:4.25E-6 ID:SGTC_1967|Compound:st070177|FD-Score:3.25|P-value:3.34E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.43|P-value:1.88E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.52|P-value:1.17E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.23|P-value:3.69E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.83|P-value:3.09E-5 ID:SGTC_2452|Compound:5863136|FD-Score:3.12|P-value:5.41E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.02|P-value:1.32E-5 ID:SGTC_2505|Compound:galangin|FD-Score:3.74|P-value:4.60E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.74|P-value:4.68E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.18|P-value:4.94E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.54|P-value:1.07E-6 ID:SGTC_2671|Compound:danthron|FD-Score:4.77|P-value:3.20E-7 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.30|P-value:2.83E-4 ID:SGTC_2783|Compound:7738165|FD-Score:6.54|P-value:4.36E-12 ID:SGTC_2798|Compound:7813637|FD-Score:7.76|P-value:2.82E-16 ID:SGTC_2800|Compound:7887935|FD-Score:4.33|P-value:3.00E-6 ID:SGTC_2836|Compound:9010338|FD-Score:3.57|P-value:9.56E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.17|P-value:5.10E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.32|P-value:2.81E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.08|P-value:6.97E-4 ID:SGTC_3012|Compound:9080433|FD-Score:2.96|P-value:9.76E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.06|P-value:7.65E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.73|P-value:4.84E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.04|P-value:7.96E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:5.12|P-value:4.53E-8 ID:SGTC_29|Compound:0299-0004|FD-Score:5.21|P-value:2.64E-8 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.62|P-value:8.69E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.30|P-value:3.03E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.22|P-value:3.85E-4 ID:SGTC_459|Compound:nigericin|FD-Score:7.22|P-value:2.46E-14 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.02|P-value:8.03E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.57|P-value:9.58E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.44|P-value:1.63E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:5.56|P-value:3.26E-9 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.08|P-value:6.47E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.21|P-value:3.94E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.66|P-value:6.42E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.18|P-value:4.47E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.62|P-value:7.55E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.24|P-value:3.52E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:2.98|P-value:8.97E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.90|P-value:2.24E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:2.97|P-value:9.37E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.03|P-value:7.65E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.90|P-value:2.33E-5 ID:SGTC_1961|Compound:st076550|FD-Score:4.26|P-value:4.25E-6 ID:SGTC_1967|Compound:st070177|FD-Score:3.25|P-value:3.34E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.43|P-value:1.88E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.52|P-value:1.17E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.23|P-value:3.69E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.83|P-value:3.09E-5 ID:SGTC_2452|Compound:5863136|FD-Score:3.12|P-value:5.41E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.02|P-value:1.32E-5 ID:SGTC_2505|Compound:galangin|FD-Score:3.74|P-value:4.60E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.74|P-value:4.68E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.18|P-value:4.94E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.54|P-value:1.07E-6 ID:SGTC_2671|Compound:danthron|FD-Score:4.77|P-value:3.20E-7 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.30|P-value:2.83E-4 ID:SGTC_2783|Compound:7738165|FD-Score:6.54|P-value:4.36E-12 ID:SGTC_2798|Compound:7813637|FD-Score:7.76|P-value:2.82E-16 ID:SGTC_2800|Compound:7887935|FD-Score:4.33|P-value:3.00E-6 ID:SGTC_2836|Compound:9010338|FD-Score:3.57|P-value:9.56E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.17|P-value:5.10E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.32|P-value:2.81E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.08|P-value:6.97E-4 ID:SGTC_3012|Compound:9080433|FD-Score:2.96|P-value:9.76E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.06|P-value:7.65E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.73|P-value:4.84E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.04|P-value:7.96E-4

Top fitness defect scores for YOL122C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2798 7813637 7.76 45.5 µM 2.82E-16 1 4.26E-15
2 SGTC_459 nigericin 7.22 15.3 µM 2.46E-14 16 2.62E-13
3 SGTC_2783 7738165 6.54 71.4 µM 4.36E-12 6 3.08E-11
4 SGTC_787 4152-0075 5.56 138.0 µM 3.26E-9 3 1.37E-8
5 SGTC_29 0299-0004 5.21 13.0 µM 2.64E-8 15 9.43E-8
6 SGTC_9 0092-0002 5.12 10.4 µM 4.53E-8 13 1.55E-7
7 SGTC_2671 danthron 4.77 100.0 µM 3.20E-7 DNA damage response 27 9.39E-7
8 SGTC_2628 lathosterol 4.54 100.0 µM 1.07E-6 17 2.86E-6
9 SGTC_2800 7887935 4.33 81.8 µM 3.00E-6 RPP1 & pyrimidine depletion 21 7.39E-6
10 SGTC_1961 st076550 4.26 68.7 µM 4.25E-6 10 1.02E-5
11 SGTC_2497 7-hydroxyflavone 4.02 100.0 µM 1.32E-5 20 2.90E-5
12 SGTC_1401 3807-4679 3.90 7.6 µM 2.24E-5 tubulin folding & SWR complex 21 4.73E-5
13 SGTC_1930 st074634 3.90 34.3 µM 2.33E-5 RNA pol III & RNase P/MRP 38 4.89E-5
14 SGTC_2329 6138490 3.83 200.0 µM 3.09E-5 37 6.35E-5
15 SGTC_2505 galangin 3.74 7.9 µM 4.60E-5 RPP1 & pyrimidine depletion 16 9.17E-5
16 SGTC_2555 cholic acid 3.74 100.0 µM 4.68E-5 20 9.32E-5
17 SGTC_3208 9114115 3.73 49.5 µM 4.84E-5 46 9.60E-5
18 SGTC_1261 0712-0010 3.66 12.7 µM 6.42E-5 RNA processing & uracil transport 30 1.25E-4
19 SGTC_1266 0828-0227 3.62 32.9 µM 7.55E-5 28 1.45E-4
20 SGTC_2836 9010338 3.57 19.5 µM 9.56E-5 RPP1 & pyrimidine depletion 47 1.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 9.32E-19 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.133 8.32E-15 YBR235W VHC1 hom Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family
0.133 9.52E-15 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.127 1.71E-13 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.125 4.39E-13 YLR296W_d YLR296W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.124 4.74E-13 YER111C SWI4 hom DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p
0.110 1.92E-10 YJR107W_p YJR107W_p hom Putative lipase
0.099 7.70E-9 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.096 2.70E-8 YGR192C TDH3 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication
0.094 5.10E-8 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.094 5.48E-8 YBR183W YPC1 hom Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication
0.090 1.88E-7 YOR021C SFM1 hom SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
0.090 2.03E-7 YER002W NOP16 hom Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.088 3.36E-7 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.088 3.63E-7 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p