YOL123W / HRP1

Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOL123W / HRP1

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.06|P-value:3.73E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.06|P-value:3.92E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.25|P-value:1.65E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.22|P-value:1.96E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:2.84|P-value:8.89E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:4.71|P-value:1.03E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:-4.06|P-value:3.64E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:3.98|P-value:5.67E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.85|P-value:8.37E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.18|P-value:2.09E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:-2.97|P-value:5.28E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:4.68|P-value:1.24E-7 ID:SGTC_972|Compound:1319-0219|FD-Score:-2.99|P-value:4.80E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.83|P-value:1.15E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.82|P-value:9.30E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.26|P-value:1.61E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.64|P-value:2.98E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.64|P-value:3.04E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:-3.27|P-value:1.54E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.67|P-value:1.32E-7 ID:SGTC_1501|Compound:4491-0275|FD-Score:2.92|P-value:6.59E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:2.94|P-value:6.01E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.49|P-value:5.80E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:2.91|P-value:6.85E-4 ID:SGTC_1687|Compound:st020778|FD-Score:2.84|P-value:8.91E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-3.13|P-value:2.71E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.45|P-value:7.10E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.60|P-value:3.49E-5 ID:SGTC_1771|Compound:st048882|FD-Score:-4.18|P-value:2.00E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.42|P-value:8.31E-5 ID:SGTC_1784|Compound:st039334|FD-Score:4.94|P-value:2.51E-8 ID:SGTC_1860|Compound:st056228|FD-Score:3.61|P-value:3.55E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.49|P-value:6.06E-5 ID:SGTC_1899|Compound:st063254|FD-Score:3.99|P-value:5.49E-6 ID:SGTC_2034|Compound:5197015|FD-Score:3.52|P-value:5.29E-5 ID:SGTC_2088|Compound:5278280|FD-Score:-3.12|P-value:2.84E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-3.46|P-value:6.54E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.35|P-value:1.08E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-4.00|P-value:5.03E-6 ID:SGTC_2467|Compound:5474540|FD-Score:-5.28|P-value:2.86E-9 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.22|P-value:1.86E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-2.99|P-value:4.74E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.33|P-value:1.17E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:2.92|P-value:6.51E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-2.81|P-value:9.56E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-2.89|P-value:6.94E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.92|P-value:7.35E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:-4.07|P-value:3.53E-6 ID:SGTC_2856|Compound:9022925|FD-Score:-4.54|P-value:2.70E-7 ID:SGTC_2916|Compound:7875993|FD-Score:3.08|P-value:3.45E-4 ID:SGTC_2918|Compound:7977171|FD-Score:2.99|P-value:4.87E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.11|P-value:3.01E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.77|P-value:1.55E-5 ID:SGTC_3012|Compound:9080433|FD-Score:3.38|P-value:9.90E-5 ID:SGTC_3289|Compound:9119912|FD-Score:-3.00|P-value:4.54E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.25|P-value:1.69E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.06|P-value:3.73E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.06|P-value:3.92E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.25|P-value:1.65E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.22|P-value:1.96E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:2.84|P-value:8.89E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:4.71|P-value:1.03E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:-4.06|P-value:3.64E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:3.98|P-value:5.67E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.85|P-value:8.37E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.18|P-value:2.09E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:-2.97|P-value:5.28E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:4.68|P-value:1.24E-7 ID:SGTC_972|Compound:1319-0219|FD-Score:-2.99|P-value:4.80E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.83|P-value:1.15E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.82|P-value:9.30E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.26|P-value:1.61E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.64|P-value:2.98E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.64|P-value:3.04E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:-3.27|P-value:1.54E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.67|P-value:1.32E-7 ID:SGTC_1501|Compound:4491-0275|FD-Score:2.92|P-value:6.59E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:2.94|P-value:6.01E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.49|P-value:5.80E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:2.91|P-value:6.85E-4 ID:SGTC_1687|Compound:st020778|FD-Score:2.84|P-value:8.91E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-3.13|P-value:2.71E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.45|P-value:7.10E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.60|P-value:3.49E-5 ID:SGTC_1771|Compound:st048882|FD-Score:-4.18|P-value:2.00E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.42|P-value:8.31E-5 ID:SGTC_1784|Compound:st039334|FD-Score:4.94|P-value:2.51E-8 ID:SGTC_1860|Compound:st056228|FD-Score:3.61|P-value:3.55E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.49|P-value:6.06E-5 ID:SGTC_1899|Compound:st063254|FD-Score:3.99|P-value:5.49E-6 ID:SGTC_2034|Compound:5197015|FD-Score:3.52|P-value:5.29E-5 ID:SGTC_2088|Compound:5278280|FD-Score:-3.12|P-value:2.84E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-3.46|P-value:6.54E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.35|P-value:1.08E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-4.00|P-value:5.03E-6 ID:SGTC_2467|Compound:5474540|FD-Score:-5.28|P-value:2.86E-9 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.22|P-value:1.86E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-2.99|P-value:4.74E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.33|P-value:1.17E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:2.92|P-value:6.51E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-2.81|P-value:9.56E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-2.89|P-value:6.94E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.92|P-value:7.35E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:-4.07|P-value:3.53E-6 ID:SGTC_2856|Compound:9022925|FD-Score:-4.54|P-value:2.70E-7 ID:SGTC_2916|Compound:7875993|FD-Score:3.08|P-value:3.45E-4 ID:SGTC_2918|Compound:7977171|FD-Score:2.99|P-value:4.87E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.11|P-value:3.01E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.77|P-value:1.55E-5 ID:SGTC_3012|Compound:9080433|FD-Score:3.38|P-value:9.90E-5 ID:SGTC_3289|Compound:9119912|FD-Score:-3.00|P-value:4.54E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.25|P-value:1.69E-4

Top fitness defect scores for YOL123W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1784 st039334 4.94 36.3 µM 2.51E-8 4 3.82E-7 0.40
2 SGTC_515 4092-1064 4.71 102.0 µM 1.03E-7 plasma membrane duress 11 1.22E-6 0.05
3 SGTC_968 1309-0633 4.68 340.0 µM 1.24E-7 1 1.43E-6 0.35
4 SGTC_1494 4358-1428 4.67 177.0 µM 1.32E-7 4 1.51E-6 0.09
5 SGTC_953 1188-0045 4.18 9.7 µM 2.09E-6 60S ribosome export 4 1.49E-5 0.15
6 SGTC_152 4469-0003 4.06 551.2 µM 3.92E-6 13 2.50E-5 0.32
7 SGTC_1899 st063254 3.99 59.6 µM 5.49E-6 3 3.31E-5 0.22
8 SGTC_696 1560-0013 3.98 611.0 µM 5.67E-6 8 3.40E-5 0.05
9 SGTC_1416 3966-0321 3.64 25.3 µM 3.04E-5 7 1.37E-4 0.09
10 SGTC_1860 st056228 3.61 74.6 µM 3.55E-5 8 1.56E-4 0.17
11 SGTC_2034 5197015 3.52 53.1 µM 5.29E-5 SWF1 & branched chain AA biosynthesis 2 2.17E-4 0.03
12 SGTC_1876 myriocin 3.49 605.0 nM 6.06E-5 7 2.43E-4 0.01
13 SGTC_1779 st039427 3.42 55.0 µM 8.31E-5 4 3.16E-4 0.10
14 SGTC_3012 9080433 3.38 71.4 µM 9.90E-5 7 3.66E-4 0.02
15 SGTC_3325 9138760 3.25 55.2 µM 1.69E-4 Golgi 9 5.71E-4 0.05
16 SGTC_385 1494-0393 3.22 12.4 µM 1.96E-4 9 6.47E-4 0.03
17 SGTC_2916 7875993 3.08 68.8 µM 3.45E-4 19 0.00104 0.10
18 SGTC_14 0354-0009 3.06 295.0 µM 3.73E-4 8 0.00111 0.03
19 SGTC_2918 7977171 2.99 22.1 µM 4.87E-4 13 0.00138 0.12
20 SGTC_1561 5-methoxyflavone 2.94 52.9 µM 6.01E-4 7 0.00164 9.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 7.28E-15 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.108 2.99E-10 YDL160C-A MHF2 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2
0.100 7.30E-9 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
0.098 1.40E-8 YDR523C SPS1 hom Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
0.091 1.27E-7 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.090 1.60E-7 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.086 6.03E-7 YDL051W LHP1 hom RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
0.086 6.20E-7 YGR138C TPO2 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication
0.082 2.00E-6 YOR029W_d YOR029W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.78E-6 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.079 4.39E-6 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.077 6.97E-6 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.075 1.37E-5 YKL089W MIF2 het Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3
0.074 1.65E-5 YDR071C PAA1 hom Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
0.074 1.67E-5 YER139C RTR1 hom CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication