YOL124C / TRM11

Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL124C / TRM11

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.60|P-value:1.08E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.09|P-value:7.66E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.23|P-value:4.62E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:6.83|P-value:9.72E-13 ID:SGTC_55|Compound:0767-0285|FD-Score:3.02|P-value:9.60E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:4.16|P-value:9.56E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:4.13|P-value:1.06E-5 ID:SGTC_228|Compound:caffeine|FD-Score:-3.74|P-value:4.96E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:-3.16|P-value:4.92E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:4.39|P-value:3.12E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:3.74|P-value:6.01E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:4.72|P-value:6.10E-7 ID:SGTC_616|Compound:4092-0450|FD-Score:3.10|P-value:7.23E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.14|P-value:5.30E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:6.78|P-value:1.41E-12 ID:SGTC_803|Compound:4488-1585|FD-Score:3.48|P-value:1.75E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.06|P-value:8.32E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.23|P-value:4.63E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.74|P-value:5.28E-7 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.01|P-value:1.90E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.70|P-value:7.21E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.18|P-value:5.55E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:-4.08|P-value:1.09E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.19|P-value:8.14E-6 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.35|P-value:2.87E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.64|P-value:9.34E-5 ID:SGTC_1830|Compound:st055982|FD-Score:3.95|P-value:2.44E-5 ID:SGTC_1868|Compound:st057644|FD-Score:-3.22|P-value:3.96E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:7.69|P-value:1.13E-15 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.16|P-value:5.89E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.53|P-value:1.17E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.29|P-value:5.15E-6 ID:SGTC_2013|Compound:4024628|FD-Score:3.19|P-value:5.28E-4 ID:SGTC_2184|Compound:6075246|FD-Score:4.17|P-value:9.15E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.52|P-value:1.49E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.32|P-value:2.67E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.55|P-value:1.44E-6 ID:SGTC_2370|Compound:9071495|FD-Score:3.47|P-value:1.84E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.19|P-value:8.27E-6 ID:SGTC_2455|Compound:5377712|FD-Score:-3.56|P-value:1.04E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.20|P-value:4.29E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.37|P-value:2.72E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.21|P-value:4.87E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.70|P-value:6.45E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.67|P-value:6.70E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.48|P-value:1.73E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.70|P-value:7.15E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.48|P-value:1.78E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.04|P-value:8.96E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.42|P-value:2.19E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.34|P-value:2.98E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.16|P-value:5.88E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-3.38|P-value:2.11E-4 ID:SGTC_3151|Compound:9099821|FD-Score:4.20|P-value:7.85E-6 ID:SGTC_3152|Compound:9099253|FD-Score:3.37|P-value:2.69E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.23|P-value:4.53E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.60|P-value:1.06E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.35|P-value:2.89E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.74|P-value:6.13E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:3.60|P-value:1.08E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.09|P-value:7.66E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.23|P-value:4.62E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:6.83|P-value:9.72E-13 ID:SGTC_55|Compound:0767-0285|FD-Score:3.02|P-value:9.60E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:4.16|P-value:9.56E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:4.13|P-value:1.06E-5 ID:SGTC_228|Compound:caffeine|FD-Score:-3.74|P-value:4.96E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:-3.16|P-value:4.92E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:4.39|P-value:3.12E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:3.74|P-value:6.01E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:4.72|P-value:6.10E-7 ID:SGTC_616|Compound:4092-0450|FD-Score:3.10|P-value:7.23E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.14|P-value:5.30E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:6.78|P-value:1.41E-12 ID:SGTC_803|Compound:4488-1585|FD-Score:3.48|P-value:1.75E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.06|P-value:8.32E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.23|P-value:4.63E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.74|P-value:5.28E-7 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.01|P-value:1.90E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.70|P-value:7.21E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.18|P-value:5.55E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:-4.08|P-value:1.09E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.19|P-value:8.14E-6 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.35|P-value:2.87E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.64|P-value:9.34E-5 ID:SGTC_1830|Compound:st055982|FD-Score:3.95|P-value:2.44E-5 ID:SGTC_1868|Compound:st057644|FD-Score:-3.22|P-value:3.96E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:7.69|P-value:1.13E-15 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.16|P-value:5.89E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.53|P-value:1.17E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.29|P-value:5.15E-6 ID:SGTC_2013|Compound:4024628|FD-Score:3.19|P-value:5.28E-4 ID:SGTC_2184|Compound:6075246|FD-Score:4.17|P-value:9.15E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.52|P-value:1.49E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.32|P-value:2.67E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.55|P-value:1.44E-6 ID:SGTC_2370|Compound:9071495|FD-Score:3.47|P-value:1.84E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.19|P-value:8.27E-6 ID:SGTC_2455|Compound:5377712|FD-Score:-3.56|P-value:1.04E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.20|P-value:4.29E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.37|P-value:2.72E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.21|P-value:4.87E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.70|P-value:6.45E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.67|P-value:6.70E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.48|P-value:1.73E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.70|P-value:7.15E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.48|P-value:1.78E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.04|P-value:8.96E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.42|P-value:2.19E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.34|P-value:2.98E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.16|P-value:5.88E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-3.38|P-value:2.11E-4 ID:SGTC_3151|Compound:9099821|FD-Score:4.20|P-value:7.85E-6 ID:SGTC_3152|Compound:9099253|FD-Score:3.37|P-value:2.69E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.23|P-value:4.53E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.60|P-value:1.06E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.35|P-value:2.89E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.74|P-value:6.13E-5

Top fitness defect scores for YOL124C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1872 amphotericin b 7.69 148.0 nM 1.13E-15 RNA pol III & RNase P/MRP 7 7.60E-15
2 SGTC_50 0929-0078 6.83 56.4 µM 9.72E-13 19 4.30E-12
3 SGTC_792 4534-1957 6.78 155.0 µM 1.41E-12 4 6.11E-12
4 SGTC_1052 3253-3998 4.74 198.0 µM 5.28E-7 6 1.05E-6
5 SGTC_562 3772-2733 4.72 112.0 µM 6.10E-7 ERG2 57 1.21E-6
6 SGTC_2763 lisinopril 4.70 49.3 µM 6.45E-7 6 1.27E-6
7 SGTC_2286 7945697 4.55 125.0 µM 1.44E-6 37 2.72E-6
8 SGTC_385 1494-0393 4.39 12.4 µM 3.12E-6 12 5.62E-6
9 SGTC_1950 st077106 4.29 7.2 µM 5.15E-6 RNA processing & uracil transport 19 9.00E-6
10 SGTC_3151 9099821 4.20 49.5 µM 7.85E-6 11 1.34E-5
11 SGTC_1129 3453-1384 4.19 223.0 µM 8.14E-6 32 1.39E-5
12 SGTC_2422 chlorphenesin carbamate 4.19 384.2 µM 8.27E-6 21 1.41E-5
13 SGTC_2184 6075246 4.17 200.0 µM 9.15E-6 19 1.55E-5
14 SGTC_62 0180-0423 4.16 3.2 µM 9.56E-6 60S ribosome export 14 1.61E-5
15 SGTC_135 0933-0004 4.13 26.4 µM 1.06E-5 60S ribosome export 18 1.78E-5
16 SGTC_1061 3448-9325 4.01 110.0 µM 1.90E-5 23 3.08E-5
17 SGTC_1830 st055982 3.95 50.3 µM 2.44E-5 16 3.89E-5
18 SGTC_550 4123-0385 3.74 25.7 µM 6.01E-5 TSC3-RPN4 34 9.12E-5
19 SGTC_3347 9188721 3.74 44.7 µM 6.13E-5 28 9.29E-5
20 SGTC_2906 7926292 3.70 26.4 µM 7.15E-5 34 1.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 7.25E-20 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.112 6.84E-11 YER048C CAJ1 hom Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
0.112 8.50E-11 YAR030C_d YAR030C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
0.104 1.40E-9 YKL013C ARC19 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.100 5.82E-9 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.095 3.15E-8 YDL179W PCL9 hom Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
0.095 3.82E-8 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.09E-7 YHL014C YLF2 hom Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.081 2.51E-6 YNR002C ATO2 hom Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication
0.081 2.95E-6 YMR053C STB2 hom Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p
0.080 3.06E-6 YIL027C EMC5 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT
0.079 4.70E-6 YNL282W POP3 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.078 6.22E-6 YDR276C PMP3 hom Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
0.078 6.65E-6 YJR087W_d YJR087W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.077 7.83E-6 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed