YOL126C / MDH2

Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL126C / MDH2

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.65|P-value:1.14E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:3.98|P-value:2.97E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.49|P-value:2.17E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.54|P-value:1.81E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.72|P-value:8.95E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.23|P-value:6.29E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.18|P-value:6.61E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.84|P-value:5.35E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.21|P-value:5.90E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.90|P-value:4.17E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:3.29|P-value:4.52E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:4.65|P-value:1.38E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:5.90|P-value:1.45E-9 ID:SGTC_955|Compound:1216-0110|FD-Score:4.00|P-value:2.72E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:3.84|P-value:5.32E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.67|P-value:1.08E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.55|P-value:1.71E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.38|P-value:3.27E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.68|P-value:1.05E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.16|P-value:7.22E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.82|P-value:6.12E-7 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.42|P-value:2.77E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.42|P-value:2.80E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.90|P-value:4.20E-5 ID:SGTC_1767|Compound:st044992|FD-Score:5.46|P-value:1.91E-8 ID:SGTC_1866|Compound:st057638|FD-Score:3.35|P-value:3.65E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.73|P-value:8.55E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.16|P-value:7.07E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.40|P-value:3.06E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.52|P-value:1.95E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.31|P-value:4.13E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.08|P-value:9.41E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.21|P-value:6.76E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.84|P-value:5.48E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.14|P-value:7.63E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.40|P-value:4.57E-6 ID:SGTC_2857|Compound:9024691|FD-Score:3.58|P-value:1.51E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.23|P-value:5.50E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.18|P-value:6.64E-4 ID:SGTC_3045|Compound:9092950|FD-Score:5.59|P-value:9.08E-9 ID:SGTC_3047|Compound:9092122|FD-Score:4.83|P-value:5.56E-7 ID:SGTC_3052|Compound:9092717|FD-Score:-4.74|P-value:1.06E-6 ID:SGTC_3108|Compound:9121785|FD-Score:-3.11|P-value:9.60E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.67|P-value:1.06E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.65|P-value:1.14E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:3.98|P-value:2.97E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.49|P-value:2.17E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.54|P-value:1.81E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.72|P-value:8.95E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.23|P-value:6.29E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.18|P-value:6.61E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.84|P-value:5.35E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.21|P-value:5.90E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.90|P-value:4.17E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:3.29|P-value:4.52E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:4.65|P-value:1.38E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:5.90|P-value:1.45E-9 ID:SGTC_955|Compound:1216-0110|FD-Score:4.00|P-value:2.72E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:3.84|P-value:5.32E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.67|P-value:1.08E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.55|P-value:1.71E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.38|P-value:3.27E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.68|P-value:1.05E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.16|P-value:7.22E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.82|P-value:6.12E-7 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.42|P-value:2.77E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.42|P-value:2.80E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.90|P-value:4.20E-5 ID:SGTC_1767|Compound:st044992|FD-Score:5.46|P-value:1.91E-8 ID:SGTC_1866|Compound:st057638|FD-Score:3.35|P-value:3.65E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.73|P-value:8.55E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.16|P-value:7.07E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.40|P-value:3.06E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.52|P-value:1.95E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.31|P-value:4.13E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.08|P-value:9.41E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.21|P-value:6.76E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.84|P-value:5.48E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.14|P-value:7.63E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.40|P-value:4.57E-6 ID:SGTC_2857|Compound:9024691|FD-Score:3.58|P-value:1.51E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.23|P-value:5.50E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.18|P-value:6.64E-4 ID:SGTC_3045|Compound:9092950|FD-Score:5.59|P-value:9.08E-9 ID:SGTC_3047|Compound:9092122|FD-Score:4.83|P-value:5.56E-7 ID:SGTC_3052|Compound:9092717|FD-Score:-4.74|P-value:1.06E-6 ID:SGTC_3108|Compound:9121785|FD-Score:-3.11|P-value:9.60E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.67|P-value:1.06E-4

Top fitness defect scores for YOL126C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_904 1141-0088 5.90 396.0 µM 1.45E-9 3 1.85E-9
2 SGTC_3045 9092950 5.59 49.5 µM 9.08E-9 4 1.14E-8
3 SGTC_1767 st044992 5.46 70.3 µM 1.91E-8 4 2.38E-8
4 SGTC_3047 9092122 4.83 49.5 µM 5.56E-7 5 6.66E-7
5 SGTC_1494 4358-1428 4.82 177.0 µM 6.12E-7 10 7.33E-7
6 SGTC_883 0850-0245 4.65 24.6 µM 1.38E-6 cell wall 17 1.63E-6
7 SGTC_2852 9023854 4.40 52.0 µM 4.57E-6 24 5.36E-6
8 SGTC_955 1216-0110 4.00 33.0 µM 2.72E-5 sphingolipid biosynthesis & PDR1 62 3.12E-5
9 SGTC_194 1486-1323 3.98 56.9 µM 2.97E-5 20 3.40E-5
10 SGTC_648 0375-0473 3.90 33.3 µM 4.17E-5 17 4.77E-5
11 SGTC_1764 st044502 3.90 93.5 µM 4.20E-5 31 4.80E-5
12 SGTC_958 1222-0007 3.84 33.0 µM 5.32E-5 28 6.06E-5
13 SGTC_571 k831-0106 3.84 44.2 µM 5.35E-5 15 6.09E-5
14 SGTC_2730 imipramine 3.84 71.3 µM 5.48E-5 28 6.25E-5
15 SGTC_1991 st073000 3.73 8.9 µM 8.55E-5 NEO1 89 9.69E-5
16 SGTC_404 fumagillin 3.72 50.0 µM 8.95E-5 27 1.01E-4
17 SGTC_1416 3966-0321 3.68 25.3 µM 1.05E-4 21 1.19E-4
18 SGTC_3327 9140648 3.67 26.9 µM 1.06E-4 15 1.19E-4
19 SGTC_1032 k061-1018 3.67 98.7 µM 1.08E-4 32 1.22E-4
20 SGTC_9 0092-0002 3.65 10.4 µM 1.14E-4 39 1.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.85E-10 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.091 1.14E-7 YPL060W MFM1 hom Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p
0.089 2.10E-7 YKL014C URB1 het Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
0.088 3.00E-7 YMR306C-A_d YMR306C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.56E-7 YGR121W-A_p YGR121W-A_p hom Putative protein of unknown function
0.083 1.32E-6 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.081 2.96E-6 YJL145W SFH5 hom Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress
0.080 3.29E-6 YDR066C RTR2 hom Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication
0.080 3.43E-6 YDR373W FRQ1 het N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily
0.079 4.47E-6 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.078 5.60E-6 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.078 6.21E-6 YNR054C ESF2 het Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
0.076 9.74E-6 YMR065W KAR5 hom Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone
0.076 1.02E-5 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.075 1.43E-5 YNL173C MDG1 hom Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations