YOL129W / VPS68

Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL129W / VPS68

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.27|P-value:9.44E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:5.18|P-value:4.26E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.22|P-value:2.95E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.41|P-value:5.81E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:7.59|P-value:2.52E-13 ID:SGTC_163|Compound:1327-0036|FD-Score:-6.34|P-value:8.17E-10 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.10|P-value:4.81E-5 ID:SGTC_283|Compound:0987-0079|FD-Score:3.81|P-value:1.46E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.28|P-value:8.86E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.47|P-value:4.81E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:4.22|P-value:2.96E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.41|P-value:5.91E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.99|P-value:1.04E-6 ID:SGTC_629|Compound:3448-6466|FD-Score:3.95|P-value:8.62E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:-7.46|P-value:6.20E-13 ID:SGTC_995|Compound:3931-2021|FD-Score:-6.07|P-value:3.77E-9 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.53|P-value:8.09E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.04|P-value:6.19E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.90|P-value:1.02E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.51|P-value:4.26E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.28|P-value:9.08E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.37|P-value:6.71E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.44|P-value:5.33E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.91|P-value:1.00E-4 ID:SGTC_1661|Compound:st013063|FD-Score:5.38|P-value:1.54E-7 ID:SGTC_1663|Compound:st014140|FD-Score:3.92|P-value:9.48E-5 ID:SGTC_1854|Compound:st056233|FD-Score:-3.36|P-value:7.01E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.37|P-value:6.70E-4 ID:SGTC_1936|Compound:st074407|FD-Score:5.01|P-value:9.27E-7 ID:SGTC_1953|Compound:st076800|FD-Score:-4.42|P-value:1.29E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.30|P-value:8.54E-4 ID:SGTC_2142|Compound:5622915|FD-Score:4.28|P-value:2.37E-5 ID:SGTC_2154|Compound:5570129|FD-Score:3.54|P-value:3.83E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.30|P-value:8.41E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.78|P-value:1.60E-4 ID:SGTC_2284|Compound:7945075|FD-Score:4.29|P-value:2.20E-5 ID:SGTC_2354|Compound:9060492|FD-Score:-3.36|P-value:6.92E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.76|P-value:1.77E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.70|P-value:2.15E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.38|P-value:6.41E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.53|P-value:3.91E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.79|P-value:1.58E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.98|P-value:7.77E-5 ID:SGTC_2794|Compound:7785382|FD-Score:-4.00|P-value:6.94E-5 ID:SGTC_2854|Compound:9024559|FD-Score:5.09|P-value:6.35E-7 ID:SGTC_2874|Compound:9043904|FD-Score:-3.59|P-value:3.12E-4 ID:SGTC_2920|Compound:7982904|FD-Score:5.68|P-value:3.32E-8 ID:SGTC_2993|Compound:9054257|FD-Score:3.49|P-value:4.55E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.93|P-value:9.20E-5 ID:SGTC_3181|Compound:9108277|FD-Score:3.65|P-value:2.61E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.96|P-value:8.24E-5 ID:SGTC_3241|Compound:9133421|FD-Score:3.57|P-value:3.48E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-3.29|P-value:8.68E-4 ID:SGTC_3349|Compound:9149703|FD-Score:4.66|P-value:4.57E-6 ID:SGTC_37|Compound:0566-0070|FD-Score:3.27|P-value:9.44E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:5.18|P-value:4.26E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.22|P-value:2.95E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.41|P-value:5.81E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:7.59|P-value:2.52E-13 ID:SGTC_163|Compound:1327-0036|FD-Score:-6.34|P-value:8.17E-10 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.10|P-value:4.81E-5 ID:SGTC_283|Compound:0987-0079|FD-Score:3.81|P-value:1.46E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.28|P-value:8.86E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.47|P-value:4.81E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:4.22|P-value:2.96E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.41|P-value:5.91E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.99|P-value:1.04E-6 ID:SGTC_629|Compound:3448-6466|FD-Score:3.95|P-value:8.62E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:-7.46|P-value:6.20E-13 ID:SGTC_995|Compound:3931-2021|FD-Score:-6.07|P-value:3.77E-9 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.53|P-value:8.09E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.04|P-value:6.19E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.90|P-value:1.02E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.51|P-value:4.26E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.28|P-value:9.08E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.37|P-value:6.71E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.44|P-value:5.33E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.91|P-value:1.00E-4 ID:SGTC_1661|Compound:st013063|FD-Score:5.38|P-value:1.54E-7 ID:SGTC_1663|Compound:st014140|FD-Score:3.92|P-value:9.48E-5 ID:SGTC_1854|Compound:st056233|FD-Score:-3.36|P-value:7.01E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.37|P-value:6.70E-4 ID:SGTC_1936|Compound:st074407|FD-Score:5.01|P-value:9.27E-7 ID:SGTC_1953|Compound:st076800|FD-Score:-4.42|P-value:1.29E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.30|P-value:8.54E-4 ID:SGTC_2142|Compound:5622915|FD-Score:4.28|P-value:2.37E-5 ID:SGTC_2154|Compound:5570129|FD-Score:3.54|P-value:3.83E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.30|P-value:8.41E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.78|P-value:1.60E-4 ID:SGTC_2284|Compound:7945075|FD-Score:4.29|P-value:2.20E-5 ID:SGTC_2354|Compound:9060492|FD-Score:-3.36|P-value:6.92E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.76|P-value:1.77E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.70|P-value:2.15E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.38|P-value:6.41E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.53|P-value:3.91E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.79|P-value:1.58E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.98|P-value:7.77E-5 ID:SGTC_2794|Compound:7785382|FD-Score:-4.00|P-value:6.94E-5 ID:SGTC_2854|Compound:9024559|FD-Score:5.09|P-value:6.35E-7 ID:SGTC_2874|Compound:9043904|FD-Score:-3.59|P-value:3.12E-4 ID:SGTC_2920|Compound:7982904|FD-Score:5.68|P-value:3.32E-8 ID:SGTC_2993|Compound:9054257|FD-Score:3.49|P-value:4.55E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.93|P-value:9.20E-5 ID:SGTC_3181|Compound:9108277|FD-Score:3.65|P-value:2.61E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.96|P-value:8.24E-5 ID:SGTC_3241|Compound:9133421|FD-Score:3.57|P-value:3.48E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-3.29|P-value:8.68E-4 ID:SGTC_3349|Compound:9149703|FD-Score:4.66|P-value:4.57E-6

Top fitness defect scores for YOL129W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_66 0109-0187 7.59 42.4 µM 2.52E-13 6 1.55E-14
2 SGTC_2920 7982904 5.68 15.8 µM 3.32E-8 1 6.84E-9
3 SGTC_1661 st013063 5.38 9.7 µM 1.54E-7 9 3.71E-8
4 SGTC_44 0929-0055 5.18 61.2 µM 4.26E-7 16 1.14E-7
5 SGTC_2854 9024559 5.09 71.4 µM 6.35E-7 8 1.76E-7
6 SGTC_1936 st074407 5.01 74.3 µM 9.27E-7 DNA damage response 12 2.67E-7
7 SGTC_584 0986-0246 4.99 15.4 µM 1.04E-6 heme requiring 3 3.05E-7
8 SGTC_3349 9149703 4.66 23.0 µM 4.57E-6 7 1.55E-6
9 SGTC_1050 3232-1156 4.53 69.3 µM 8.09E-6 RSC complex & mRNA processing 12 2.90E-6
10 SGTC_2284 7945075 4.29 39.2 µM 2.20E-5 mitochondrial processes 20 8.74E-6
11 SGTC_2142 5622915 4.28 118.5 µM 2.37E-5 8 9.49E-6
12 SGTC_496 calpeptin 4.22 138.0 µM 2.96E-5 12 1.21E-5
13 SGTC_240 5hr heat shock (37°C) + Streptovitacin 4.10 300.0 µM 4.81E-5 heat shock/prefoldin 34 2.06E-5
14 SGTC_1053 3366-3204 4.04 134.0 µM 6.19E-5 cell wall 35 2.72E-5
15 SGTC_2778 tioconazole 3.98 65.1 nM 7.77E-5 ergosterol depletion effects on membrane 59 3.49E-5
16 SGTC_3236 9132701 3.96 49.5 µM 8.24E-5 TSC3-RPN4 26 3.73E-5
17 SGTC_629 3448-6466 3.95 76.7 µM 8.62E-5 19 3.92E-5
18 SGTC_3054 9094397 3.93 49.5 µM 9.20E-5 fatty acid desaturase (OLE1) 30 4.21E-5
19 SGTC_1663 st014140 3.92 55.4 µM 9.48E-5 60S ribosome export 16 4.35E-5
20 SGTC_1600 coumarin 106 3.91 71.1 µM 1.00E-4 29 4.64E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 3.68E-12 YOR136W IDH2 hom Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
0.104 1.85E-9 YOR222W ODC2 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
0.090 2.00E-7 YIL015W BAR1 hom Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
0.088 2.82E-7 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.085 9.40E-7 YMR294W-A_d YMR294W-A_d hom Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents
0.080 3.37E-6 YGL261C_p PAU11_p hom Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2
0.080 3.63E-6 YPL224C MMT2 hom Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
0.080 3.81E-6 YDR516C EMI2 hom Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.079 4.88E-6 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.078 5.55E-6 YLR312C_p YLR312C_p hom Putative protein of unknown function
0.076 1.03E-5 YDR033W MRH1 hom Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication
0.076 1.16E-5 YER104W RTT105 het Protein with a role in regulation of Ty1 transposition
0.075 1.20E-5 YOL006C TOP1 hom Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
0.075 1.50E-5 YMR056C AAC1 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.074 1.89E-5 YPL204W HRR25 het Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)