YOL134C_d

Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOL134C / YOL134C

Click on Significant Values for Screen Details ID:SGTC_123|Compound:0083-0120|FD-Score:-3.06|P-value:9.34E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.11|P-value:7.74E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.10|P-value:7.96E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.99|P-value:1.94E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:4.29|P-value:6.50E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:4.27|P-value:7.09E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:5.62|P-value:5.27E-9 ID:SGTC_374|Compound:0880-0231|FD-Score:3.10|P-value:8.06E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.93|P-value:3.18E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.23|P-value:5.05E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:6.26|P-value:9.64E-11 ID:SGTC_685|Compound:1278-0033|FD-Score:5.81|P-value:1.75E-9 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.41|P-value:2.59E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:5.15|P-value:8.09E-8 ID:SGTC_798|Compound:1287-0182|FD-Score:3.12|P-value:7.60E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:4.72|P-value:7.71E-7 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.50|P-value:1.87E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.10|P-value:8.20E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.28|P-value:4.27E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.09|P-value:8.25E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-6.36|P-value:4.71E-11 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.77|P-value:6.35E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.08|P-value:8.73E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.46|P-value:2.14E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:10.20|P-value:2.32E-25 ID:SGTC_1462|Compound:k081-0014|FD-Score:-9.77|P-value:1.29E-23 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.17|P-value:7.27E-8 ID:SGTC_1464|Compound:k208-0027|FD-Score:-4.10|P-value:1.47E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.07|P-value:8.98E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.12|P-value:1.39E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.72|P-value:2.89E-9 ID:SGTC_1827|Compound:berberine|FD-Score:3.78|P-value:5.95E-5 ID:SGTC_1829|Compound:berberine|FD-Score:3.29|P-value:4.15E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.17|P-value:6.32E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.11|P-value:7.69E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.22|P-value:8.83E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-3.24|P-value:4.95E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.95|P-value:2.90E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.86|P-value:4.28E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-3.79|P-value:5.64E-5 ID:SGTC_3221|Compound:9128209|FD-Score:-3.67|P-value:9.43E-5 ID:SGTC_3223|Compound:9129970|FD-Score:-4.32|P-value:5.55E-6 ID:SGTC_123|Compound:0083-0120|FD-Score:-3.06|P-value:9.34E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.11|P-value:7.74E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.10|P-value:7.96E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.99|P-value:1.94E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:4.29|P-value:6.50E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:4.27|P-value:7.09E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:5.62|P-value:5.27E-9 ID:SGTC_374|Compound:0880-0231|FD-Score:3.10|P-value:8.06E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.93|P-value:3.18E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.23|P-value:5.05E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:6.26|P-value:9.64E-11 ID:SGTC_685|Compound:1278-0033|FD-Score:5.81|P-value:1.75E-9 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.41|P-value:2.59E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:5.15|P-value:8.09E-8 ID:SGTC_798|Compound:1287-0182|FD-Score:3.12|P-value:7.60E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:4.72|P-value:7.71E-7 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.50|P-value:1.87E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.10|P-value:8.20E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.28|P-value:4.27E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.09|P-value:8.25E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-6.36|P-value:4.71E-11 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.77|P-value:6.35E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.08|P-value:8.73E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.46|P-value:2.14E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:10.20|P-value:2.32E-25 ID:SGTC_1462|Compound:k081-0014|FD-Score:-9.77|P-value:1.29E-23 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.17|P-value:7.27E-8 ID:SGTC_1464|Compound:k208-0027|FD-Score:-4.10|P-value:1.47E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.07|P-value:8.98E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.12|P-value:1.39E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.72|P-value:2.89E-9 ID:SGTC_1827|Compound:berberine|FD-Score:3.78|P-value:5.95E-5 ID:SGTC_1829|Compound:berberine|FD-Score:3.29|P-value:4.15E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.17|P-value:6.32E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.11|P-value:7.69E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.22|P-value:8.83E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-3.24|P-value:4.95E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.95|P-value:2.90E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.86|P-value:4.28E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-3.79|P-value:5.64E-5 ID:SGTC_3221|Compound:9128209|FD-Score:-3.67|P-value:9.43E-5 ID:SGTC_3223|Compound:9129970|FD-Score:-4.32|P-value:5.55E-6

Top fitness defect scores for YOL134C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1450 4112-4260 10.20 37.6 µM 2.32E-25 calcium & mitochondrial duress 1 1.47E-24 3.96
2 SGTC_568 1193-0097 6.26 7.5 µM 9.64E-11 ERAD & cell cycle 13 1.96E-10 0.03
3 SGTC_685 1278-0033 5.81 54.9 µM 1.75E-9 60S ribosome export 3 3.22E-9 0.57
4 SGTC_1787 fluconazole 5.72 80.0 µM 2.89E-9 iron homeostasis 3 5.23E-9 0.55
5 SGTC_312 4092-0653 5.62 6.8 µM 5.27E-9 ergosterol depletion effects on membrane 16 9.37E-9 0.35
6 SGTC_769 0302-0231 5.15 76.0 µM 8.09E-8 5 1.31E-7 0.17
7 SGTC_268 camptothecin 4.99 39.6 µM 1.94E-7 DNA damage response 30 3.06E-7 0.04
8 SGTC_882 0843-0131 4.72 351.0 µM 7.71E-7 6 1.16E-6 0.03
9 SGTC_279 1273-0055 4.29 2.9 µM 6.50E-6 azole & statin 1 9.12E-6 0.69
10 SGTC_280 3448-3607 4.27 3.0 µM 7.09E-6 60S ribosome export 2 9.91E-6 0.05
11 SGTC_2289 7946404 4.22 165.1 µM 8.83E-6 18 1.23E-5 0.13
12 SGTC_1786 berberine 4.12 21.6 µM 1.39E-5 60S ribosome export 16 1.91E-5 0.00
13 SGTC_2760 etidronate 3.95 98.0 µM 2.90E-5 6 3.87E-5 0.15
14 SGTC_410 α-linolenic acid 3.93 100.0 µM 3.18E-5 excess fatty acid 4 4.23E-5 0.03
15 SGTC_1827 berberine 3.78 7.2 µM 5.95E-5 60S ribosome export 13 7.77E-5 0.13
16 SGTC_1125 tnp00248 3.77 1.3 µM 6.35E-5 12 8.27E-5 0.06
17 SGTC_1829 berberine 3.29 14.4 µM 4.15E-4 60S ribosome export 19 5.09E-4 0.01
18 SGTC_419 nsc-638432 3.23 893.0 µM 5.05E-4 DNA damage response 11 6.16E-4 0.15
19 SGTC_1911 st060208 3.17 74.3 µM 6.32E-4 14 7.65E-4 0.10
20 SGTC_798 1287-0182 3.12 476.0 µM 7.60E-4 9 9.14E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.266 2.02E-55 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.254 2.17E-50 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.254 2.27E-50 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.239 8.73E-45 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.239 1.16E-44 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.230 2.62E-41 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.227 2.79E-40 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.209 2.20E-34 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.198 7.09E-31 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.197 9.61E-31 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.197 1.36E-30 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.195 6.25E-30 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.193 2.16E-29 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.188 3.89E-28 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.188 5.52E-28 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress