YOL137W / BSC6

Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL137W / BSC6

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.73|P-value:1.06E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.25|P-value:6.33E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.14|P-value:9.31E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.04|P-value:9.78E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.45|P-value:3.13E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.54|P-value:1.58E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.17|P-value:8.38E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.69|P-value:1.25E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.17|P-value:8.55E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.58|P-value:1.93E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.17|P-value:8.59E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.40|P-value:6.14E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.41|P-value:3.83E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.55|P-value:2.19E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.42|P-value:3.52E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.51|P-value:3.72E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.37|P-value:4.26E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.97|P-value:4.09E-5 ID:SGTC_1948|Compound:st076329|FD-Score:-3.76|P-value:6.60E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-3.14|P-value:6.80E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.40|P-value:3.70E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.13|P-value:9.68E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-3.28|P-value:4.27E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.38|P-value:4.10E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.18|P-value:1.24E-7 ID:SGTC_2646|Compound:retinol|FD-Score:3.16|P-value:8.80E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.80|P-value:8.02E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:4.10|P-value:2.28E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:7.20|P-value:3.24E-13 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.63|P-value:1.57E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.41|P-value:5.69E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-3.24|P-value:4.82E-4 ID:SGTC_3267|Compound:9137951|FD-Score:4.04|P-value:3.00E-5 ID:SGTC_3280|Compound:9140961|FD-Score:3.39|P-value:3.95E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.91|P-value:5.13E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.50|P-value:2.61E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.73|P-value:1.06E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.25|P-value:6.33E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.14|P-value:9.31E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.04|P-value:9.78E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.45|P-value:3.13E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.54|P-value:1.58E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.17|P-value:8.38E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.69|P-value:1.25E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.17|P-value:8.55E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.58|P-value:1.93E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.17|P-value:8.59E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.40|P-value:6.14E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.41|P-value:3.83E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.55|P-value:2.19E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.42|P-value:3.52E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.51|P-value:3.72E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.37|P-value:4.26E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.97|P-value:4.09E-5 ID:SGTC_1948|Compound:st076329|FD-Score:-3.76|P-value:6.60E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-3.14|P-value:6.80E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.40|P-value:3.70E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.13|P-value:9.68E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-3.28|P-value:4.27E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.38|P-value:4.10E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.18|P-value:1.24E-7 ID:SGTC_2646|Compound:retinol|FD-Score:3.16|P-value:8.80E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.80|P-value:8.02E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:4.10|P-value:2.28E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:7.20|P-value:3.24E-13 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.63|P-value:1.57E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.41|P-value:5.69E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-3.24|P-value:4.82E-4 ID:SGTC_3267|Compound:9137951|FD-Score:4.04|P-value:3.00E-5 ID:SGTC_3280|Compound:9140961|FD-Score:3.39|P-value:3.95E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.91|P-value:5.13E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.50|P-value:2.61E-4

Top fitness defect scores for YOL137W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2756 carbadox 7.20 75.1 µM 3.24E-13 11 2.94E-13
2 SGTC_2603 homopterocarpin 5.18 100.0 µM 1.24E-7 11 1.10E-7
3 SGTC_1342 1486-1464 4.51 234.0 µM 3.72E-6 6 3.31E-6
4 SGTC_2844 9010103 4.41 26.0 µM 5.69E-6 20 5.06E-6
5 SGTC_1193 1488-0126 4.40 41.5 µM 6.14E-6 19 5.46E-6
6 SGTC_2754 granisetron 4.10 64.0 µM 2.28E-5 27 2.03E-5
7 SGTC_3267 9137951 4.04 49.5 µM 3.00E-5 5 2.68E-5
8 SGTC_1520 flindersine 3.97 88.0 µM 4.09E-5 31 3.64E-5
9 SGTC_3285 9112818 3.91 20.9 µM 5.13E-5 cell wall 31 4.57E-5
10 SGTC_2668 2',4'-dihydroxychalcone 3.80 15.1 µM 8.02E-5 16 7.16E-5
11 SGTC_6 0844-0013 3.73 19.8 µM 1.06E-4 112 9.50E-5
12 SGTC_349 k015-0014 3.69 24.0 µM 1.25E-4 26 1.12E-4
13 SGTC_2771 fluoxetine 3.63 41.0 µM 1.57E-4 29 1.41E-4
14 SGTC_854 0422-0053 3.58 192.0 µM 1.93E-4 PDR1 24 1.73E-4
15 SGTC_1297 1068-0111 3.55 14.1 µM 2.19E-4 20 1.96E-4
16 SGTC_3309 9129340 3.50 25.8 µM 2.61E-4 26 2.34E-4
17 SGTC_278 4092-0821 3.45 23.9 µM 3.13E-4 plasma membrane duress 62 2.80E-4
18 SGTC_1311 1190-0148 3.42 100.0 µM 3.52E-4 azole & statin 46 3.16E-4
19 SGTC_2181 6316240 3.40 54.3 µM 3.70E-4 39 3.32E-4
20 SGTC_3280 9140961 3.39 49.5 µM 3.95E-4 60S ribosome export 30 3.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 6.37E-13 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.118 8.25E-12 YJL201W ECM25 hom Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
0.109 2.43E-10 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.108 3.00E-10 YNR049C MSO1 hom Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress
0.106 7.34E-10 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.105 1.01E-9 YGR279C SCW4 hom Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
0.104 1.82E-9 YLR398C SKI2 hom Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.102 3.69E-9 YDR316W OMS1 hom Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations
0.101 5.15E-9 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.100 6.80E-9 YPR096C YPR096C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.099 9.41E-9 YNR032W PPG1 hom Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
0.098 1.37E-8 YDR239C YDR239C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.094 5.05E-8 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.092 1.03E-7 YBR085C-A YBR085C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress
0.091 1.16E-7 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms