YOL138C / RTC1

Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL138C / RTC1

Click on Significant Values for Screen Details ID:SGTC_119|Compound:0121-0043|FD-Score:3.68|P-value:1.36E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.23|P-value:6.82E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.93|P-value:4.92E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:3.53|P-value:2.35E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:8.54|P-value:1.31E-17 ID:SGTC_163|Compound:1327-0036|FD-Score:5.00|P-value:3.60E-7 ID:SGTC_170|Compound:4197-0004|FD-Score:3.55|P-value:2.21E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:-3.65|P-value:1.51E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-4.78|P-value:1.10E-6 ID:SGTC_591|Compound:4299-0174|FD-Score:3.32|P-value:5.00E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:4.07|P-value:2.82E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:3.13|P-value:9.57E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.23|P-value:6.99E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.60|P-value:1.80E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.21|P-value:1.54E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:3.36|P-value:4.41E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.18|P-value:8.06E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.16|P-value:8.81E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.26|P-value:1.21E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.19|P-value:8.06E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.26|P-value:1.26E-5 ID:SGTC_1675|Compound:st018485|FD-Score:4.17|P-value:1.79E-5 ID:SGTC_1743|Compound:st037606|FD-Score:3.61|P-value:1.79E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.30|P-value:5.46E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.30|P-value:5.44E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.42|P-value:6.13E-6 ID:SGTC_1942|Compound:st076330|FD-Score:-3.70|P-value:1.22E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:5.14|P-value:1.78E-7 ID:SGTC_2010|Compound:4012422|FD-Score:-3.84|P-value:6.99E-5 ID:SGTC_2011|Compound:4012611|FD-Score:-3.62|P-value:1.66E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.75|P-value:1.00E-4 ID:SGTC_2227|Compound:7312221|FD-Score:3.21|P-value:7.53E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.20|P-value:7.76E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.84|P-value:7.06E-5 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.86|P-value:6.68E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.70|P-value:1.25E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.13|P-value:9.55E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.33|P-value:4.75E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.13|P-value:9.76E-4 ID:SGTC_2793|Compound:7325131|FD-Score:6.60|P-value:3.20E-11 ID:SGTC_2832|Compound:7992762|FD-Score:3.60|P-value:1.85E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.18|P-value:8.24E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.75|P-value:1.01E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.68|P-value:1.36E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.23|P-value:6.82E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.93|P-value:4.92E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:3.53|P-value:2.35E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:8.54|P-value:1.31E-17 ID:SGTC_163|Compound:1327-0036|FD-Score:5.00|P-value:3.60E-7 ID:SGTC_170|Compound:4197-0004|FD-Score:3.55|P-value:2.21E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:-3.65|P-value:1.51E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-4.78|P-value:1.10E-6 ID:SGTC_591|Compound:4299-0174|FD-Score:3.32|P-value:5.00E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:4.07|P-value:2.82E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:3.13|P-value:9.57E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.23|P-value:6.99E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.60|P-value:1.80E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.21|P-value:1.54E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:3.36|P-value:4.41E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.18|P-value:8.06E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.16|P-value:8.81E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.26|P-value:1.21E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.19|P-value:8.06E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.26|P-value:1.26E-5 ID:SGTC_1675|Compound:st018485|FD-Score:4.17|P-value:1.79E-5 ID:SGTC_1743|Compound:st037606|FD-Score:3.61|P-value:1.79E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.30|P-value:5.46E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.30|P-value:5.44E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.42|P-value:6.13E-6 ID:SGTC_1942|Compound:st076330|FD-Score:-3.70|P-value:1.22E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:5.14|P-value:1.78E-7 ID:SGTC_2010|Compound:4012422|FD-Score:-3.84|P-value:6.99E-5 ID:SGTC_2011|Compound:4012611|FD-Score:-3.62|P-value:1.66E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.75|P-value:1.00E-4 ID:SGTC_2227|Compound:7312221|FD-Score:3.21|P-value:7.53E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.20|P-value:7.76E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.84|P-value:7.06E-5 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.86|P-value:6.68E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.70|P-value:1.25E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.13|P-value:9.55E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.33|P-value:4.75E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.13|P-value:9.76E-4 ID:SGTC_2793|Compound:7325131|FD-Score:6.60|P-value:3.20E-11 ID:SGTC_2832|Compound:7992762|FD-Score:3.60|P-value:1.85E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.18|P-value:8.24E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.75|P-value:1.01E-4

Top fitness defect scores for YOL138C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_162 k030-0015 8.54 37.8 µM 1.31E-17 iron homeostasis 1 6.48E-18
2 SGTC_2793 7325131 6.60 81.8 µM 3.20E-11 3 2.09E-11
3 SGTC_1951 sophoraflavanone G 5.14 9.2 µM 1.78E-7 RNA processing & uracil transport 4 1.36E-7
4 SGTC_163 1327-0036 5.00 7.5 µM 3.60E-7 63 2.80E-7
5 SGTC_1929 genistein trimethyl ether 4.42 50.5 µM 6.13E-6 9 5.02E-6
6 SGTC_1159 4092-0538 4.26 61.2 µM 1.21E-5 21 1.00E-5
7 SGTC_1366 1683-0113 4.26 21.9 µM 1.26E-5 6 1.04E-5
8 SGTC_831 k061-1017 4.21 217.0 µM 1.54E-5 translation 49 1.28E-5
9 SGTC_1675 st018485 4.17 24.5 µM 1.79E-5 60S ribosome export 20 1.50E-5
10 SGTC_599 1935-0052 4.07 86.5 µM 2.82E-5 18 2.38E-5
11 SGTC_2655 perillic acid 3.86 100.0 µM 6.68E-5 5 5.73E-5
12 SGTC_2651 1327-0036 3.84 5.0 µM 7.06E-5 166 6.06E-5
13 SGTC_2203 7227154 3.75 166.4 µM 1.00E-4 19 8.67E-5
14 SGTC_3350 9150499 3.75 3.6 µM 1.01E-4 cell wall 63 8.73E-5
15 SGTC_2668 2',4'-dihydroxychalcone 3.70 15.1 µM 1.25E-4 19 1.08E-4
16 SGTC_119 0121-0043 3.68 24.8 µM 1.36E-4 mitochondrial stress 137 1.18E-4
17 SGTC_1743 st037606 3.61 46.4 µM 1.79E-4 30 1.56E-4
18 SGTC_640 3381-0960 3.60 37.1 µM 1.80E-4 22 1.57E-4
19 SGTC_2832 7992762 3.60 52.0 µM 1.85E-4 42 1.61E-4
20 SGTC_170 4197-0004 3.55 226.0 µM 2.21E-4 28 1.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.50E-21 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.143 9.74E-17 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.135 4.77E-15 YKR017C HEL1 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)
0.131 2.79E-14 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.127 1.85E-13 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.123 8.18E-13 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.120 3.05E-12 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.116 1.40E-11 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.114 2.95E-11 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.114 3.47E-11 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.112 8.33E-11 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.111 1.38E-10 YFR026C ULI1 hom Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.108 3.72E-10 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.107 4.95E-10 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.106 7.01E-10 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate