YOL143C / RIB4

Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL143C / RIB4

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:3.47|P-value:3.20E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.14|P-value:6.57E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.82|P-value:8.36E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:3.60|P-value:1.94E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.75|P-value:1.10E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.73|P-value:1.18E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.16|P-value:6.19E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.22|P-value:1.55E-5 ID:SGTC_509|Compound:pifithrin|FD-Score:-3.44|P-value:2.19E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:5.24|P-value:1.05E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.15|P-value:1.16E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-5.15|P-value:8.30E-8 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.69|P-value:1.39E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.40|P-value:4.17E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.09|P-value:7.86E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.30|P-value:5.93E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.90|P-value:6.00E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.44|P-value:3.64E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.41|P-value:3.94E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.43|P-value:3.77E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.05|P-value:8.77E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.27|P-value:6.52E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.17|P-value:9.43E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.42|P-value:2.33E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.99|P-value:4.15E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.61|P-value:1.92E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.82|P-value:4.95E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-4.09|P-value:1.55E-5 ID:SGTC_2011|Compound:4012611|FD-Score:-3.51|P-value:1.67E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.18|P-value:8.81E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.19|P-value:8.79E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.97|P-value:4.45E-7 ID:SGTC_2162|Compound:5663267|FD-Score:4.12|P-value:2.36E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.48|P-value:3.13E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.77|P-value:1.01E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.26|P-value:7.25E-6 ID:SGTC_2413|Compound:inermin|FD-Score:-3.81|P-value:5.07E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-4.35|P-value:4.72E-6 ID:SGTC_2455|Compound:5377712|FD-Score:6.90|P-value:3.64E-12 ID:SGTC_2464|Compound:5717415|FD-Score:-5.23|P-value:5.60E-8 ID:SGTC_2467|Compound:5474540|FD-Score:-4.23|P-value:8.15E-6 ID:SGTC_2471|Compound:5466956|FD-Score:4.50|P-value:4.45E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.24|P-value:1.40E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-4.26|P-value:7.04E-6 ID:SGTC_2488|Compound:5268135|FD-Score:4.42|P-value:6.26E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.64|P-value:1.02E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.26|P-value:6.82E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-4.00|P-value:2.32E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.35|P-value:3.09E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.56|P-value:2.31E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.25|P-value:7.01E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.35|P-value:4.93E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.54|P-value:2.49E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.47|P-value:3.20E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.14|P-value:6.57E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.82|P-value:8.36E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:3.60|P-value:1.94E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.75|P-value:1.10E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.73|P-value:1.18E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.16|P-value:6.19E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.22|P-value:1.55E-5 ID:SGTC_509|Compound:pifithrin|FD-Score:-3.44|P-value:2.19E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:5.24|P-value:1.05E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.15|P-value:1.16E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-5.15|P-value:8.30E-8 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.69|P-value:1.39E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.40|P-value:4.17E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.09|P-value:7.86E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.30|P-value:5.93E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.90|P-value:6.00E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.44|P-value:3.64E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.41|P-value:3.94E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.43|P-value:3.77E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.05|P-value:8.77E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.27|P-value:6.52E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.17|P-value:9.43E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.42|P-value:2.33E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.99|P-value:4.15E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.61|P-value:1.92E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.82|P-value:4.95E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-4.09|P-value:1.55E-5 ID:SGTC_2011|Compound:4012611|FD-Score:-3.51|P-value:1.67E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.18|P-value:8.81E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.19|P-value:8.79E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.97|P-value:4.45E-7 ID:SGTC_2162|Compound:5663267|FD-Score:4.12|P-value:2.36E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.48|P-value:3.13E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.77|P-value:1.01E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.26|P-value:7.25E-6 ID:SGTC_2413|Compound:inermin|FD-Score:-3.81|P-value:5.07E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-4.35|P-value:4.72E-6 ID:SGTC_2455|Compound:5377712|FD-Score:6.90|P-value:3.64E-12 ID:SGTC_2464|Compound:5717415|FD-Score:-5.23|P-value:5.60E-8 ID:SGTC_2467|Compound:5474540|FD-Score:-4.23|P-value:8.15E-6 ID:SGTC_2471|Compound:5466956|FD-Score:4.50|P-value:4.45E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.24|P-value:1.40E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-4.26|P-value:7.04E-6 ID:SGTC_2488|Compound:5268135|FD-Score:4.42|P-value:6.26E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.64|P-value:1.02E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.26|P-value:6.82E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-4.00|P-value:2.32E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.35|P-value:3.09E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.56|P-value:2.31E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.25|P-value:7.01E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.35|P-value:4.93E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.54|P-value:2.49E-4

Top fitness defect scores for YOL143C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2455 5377712 6.90 9.8 µM 3.64E-12 4 2.61E-12
2 SGTC_695 3505-6186 5.24 243.0 µM 1.05E-7 7 7.98E-8
3 SGTC_2157 5649910 4.97 96.4 µM 4.45E-7 8 3.40E-7
4 SGTC_2471 5466956 4.50 24.8 µM 4.45E-6 mitochondrial processes 5 3.46E-6
5 SGTC_2488 5268135 4.42 45.7 µM 6.26E-6 38 4.88E-6
6 SGTC_2472 5377652 4.24 49.4 µM 1.40E-5 TRP & mitochondrial translation 46 1.10E-5
7 SGTC_364 0083-0097 4.22 67.7 µM 1.55E-5 19 1.22E-5
8 SGTC_2162 5663267 4.12 200.0 µM 2.36E-5 10 1.86E-5
9 SGTC_1996 st072960 3.99 66.8 µM 4.15E-5 13 3.30E-5
10 SGTC_1158 4092-0494 3.90 91.8 µM 6.00E-5 17 4.78E-5
11 SGTC_166 k072-0058 3.82 166.4 µM 8.36E-5 DNA intercalators 43 6.68E-5
12 SGTC_2406 ethylparaben 3.77 405.7 µM 1.01E-4 49 8.12E-5
13 SGTC_251 melphalan 3.75 456.5 µM 1.10E-4 DNA damage response 34 8.85E-5
14 SGTC_270 tamoxifen 3.73 5.5 µM 1.18E-4 NEO1 37 9.44E-5
15 SGTC_1030 k029-0042 3.69 36.7 µM 1.39E-4 TSC3-RPN4 34 1.12E-4
16 SGTC_2000 st075254 3.61 36.4 µM 1.92E-4 15 1.55E-4
17 SGTC_181 1447-1644 3.60 8.1 µM 1.94E-4 endomembrane recycling 44 1.56E-4
18 SGTC_2739 tacrine 3.56 100.9 µM 2.31E-4 heme requiring 30 1.87E-4
19 SGTC_3215 9129942 3.54 49.5 µM 2.49E-4 18 2.02E-4
20 SGTC_2365 9042475 3.48 200.0 µM 3.13E-4 58 2.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.39E-11 YBL035C POL12 het B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
0.090 1.54E-7 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.088 3.15E-7 YML108W YML108W hom Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress
0.085 8.64E-7 YPL213W LEA1 hom Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein
0.084 1.12E-6 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.082 2.05E-6 YGL038C OCH1 hom Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
0.078 6.72E-6 YPL223C GRE1 hom Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
0.074 1.95E-5 YBR041W FAT1 hom Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids
0.073 2.57E-5 YBR022W POA1 hom Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
0.072 2.67E-5 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.072 2.71E-5 YHR194W MDM31 hom Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34
0.072 2.95E-5 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.068 8.55E-5 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.067 9.50E-5 YML032C RAD52 hom Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
0.067 1.05E-4 YER046W-A_d YER046W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data