YOL145C / CTR9

Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL145C / CTR9

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:4.80|P-value:4.83E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:3.58|P-value:5.35E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.11|P-value:8.26E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.55|P-value:2.43E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.73|P-value:3.19E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.45|P-value:8.35E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.67|P-value:1.58E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.42|P-value:9.15E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.45|P-value:8.16E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.47|P-value:7.66E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:6.45|P-value:1.02E-9 ID:SGTC_444|Compound:curcumin|FD-Score:-3.27|P-value:6.28E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.81|P-value:9.38E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-3.84|P-value:8.35E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:4.31|P-value:3.72E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.51|P-value:6.73E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.50|P-value:7.00E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.63|P-value:2.33E-8 ID:SGTC_592|Compound:k241-0073|FD-Score:3.71|P-value:3.43E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.39|P-value:9.96E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.62|P-value:4.78E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.98|P-value:1.30E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.28|P-value:6.14E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:6.13|P-value:6.39E-9 ID:SGTC_823|Compound:0417-1665|FD-Score:3.58|P-value:5.41E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.42|P-value:9.07E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.79|P-value:2.64E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.45|P-value:8.21E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.72|P-value:6.89E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.45|P-value:8.25E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.26|P-value:4.51E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.93|P-value:1.57E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.03|P-value:1.08E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.28|P-value:6.03E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.83|P-value:8.60E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.70|P-value:3.61E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.39|P-value:2.71E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.44|P-value:2.25E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.50|P-value:7.15E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.22|P-value:5.24E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-3.50|P-value:2.87E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.18|P-value:8.46E-4 ID:SGTC_1656|Compound:st012921|FD-Score:4.41|P-value:2.52E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.05|P-value:1.02E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.44|P-value:8.69E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.82|P-value:9.05E-5 ID:SGTC_1781|Compound:st038725|FD-Score:5.68|P-value:7.22E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.49|P-value:3.00E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.67|P-value:4.01E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.45|P-value:8.32E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.74|P-value:3.13E-4 ID:SGTC_1950|Compound:st077106|FD-Score:5.37|P-value:3.49E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-3.22|P-value:7.34E-4 ID:SGTC_2278|Compound:7948257|FD-Score:-4.03|P-value:4.02E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-4.16|P-value:2.36E-5 ID:SGTC_2292|Compound:7671323|FD-Score:4.53|P-value:1.53E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.91|P-value:1.69E-4 ID:SGTC_2319|Compound:6033012|FD-Score:5.59|P-value:1.11E-7 ID:SGTC_2393|Compound:9031399|FD-Score:5.34|P-value:4.00E-7 ID:SGTC_2480|Compound:5767542|FD-Score:3.63|P-value:4.63E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:4.29|P-value:4.11E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.74|P-value:3.14E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.74|P-value:1.19E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-4.13|P-value:2.63E-5 ID:SGTC_2744|Compound:captopril|FD-Score:3.81|P-value:2.48E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.04|P-value:1.04E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.77|P-value:2.83E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.33|P-value:5.15E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.74|P-value:3.14E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.67|P-value:1.58E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-4.09|P-value:3.05E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.90|P-value:1.78E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-4.77|P-value:1.69E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.77|P-value:2.80E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.83|P-value:2.24E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:4.80|P-value:4.83E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:3.58|P-value:5.35E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.11|P-value:8.26E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.55|P-value:2.43E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.73|P-value:3.19E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.45|P-value:8.35E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.67|P-value:1.58E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.42|P-value:9.15E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.45|P-value:8.16E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.47|P-value:7.66E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:6.45|P-value:1.02E-9 ID:SGTC_444|Compound:curcumin|FD-Score:-3.27|P-value:6.28E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.81|P-value:9.38E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-3.84|P-value:8.35E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:4.31|P-value:3.72E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.51|P-value:6.73E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.50|P-value:7.00E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.63|P-value:2.33E-8 ID:SGTC_592|Compound:k241-0073|FD-Score:3.71|P-value:3.43E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.39|P-value:9.96E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.62|P-value:4.78E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.98|P-value:1.30E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.28|P-value:6.14E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:6.13|P-value:6.39E-9 ID:SGTC_823|Compound:0417-1665|FD-Score:3.58|P-value:5.41E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.42|P-value:9.07E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.79|P-value:2.64E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.45|P-value:8.21E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.72|P-value:6.89E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.45|P-value:8.25E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.26|P-value:4.51E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.93|P-value:1.57E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.03|P-value:1.08E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.28|P-value:6.03E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.83|P-value:8.60E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.70|P-value:3.61E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.39|P-value:2.71E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.44|P-value:2.25E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.50|P-value:7.15E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.22|P-value:5.24E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-3.50|P-value:2.87E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.18|P-value:8.46E-4 ID:SGTC_1656|Compound:st012921|FD-Score:4.41|P-value:2.52E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.05|P-value:1.02E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.44|P-value:8.69E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.82|P-value:9.05E-5 ID:SGTC_1781|Compound:st038725|FD-Score:5.68|P-value:7.22E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.49|P-value:3.00E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.67|P-value:4.01E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.45|P-value:8.32E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.74|P-value:3.13E-4 ID:SGTC_1950|Compound:st077106|FD-Score:5.37|P-value:3.49E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-3.22|P-value:7.34E-4 ID:SGTC_2278|Compound:7948257|FD-Score:-4.03|P-value:4.02E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-4.16|P-value:2.36E-5 ID:SGTC_2292|Compound:7671323|FD-Score:4.53|P-value:1.53E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.91|P-value:1.69E-4 ID:SGTC_2319|Compound:6033012|FD-Score:5.59|P-value:1.11E-7 ID:SGTC_2393|Compound:9031399|FD-Score:5.34|P-value:4.00E-7 ID:SGTC_2480|Compound:5767542|FD-Score:3.63|P-value:4.63E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:4.29|P-value:4.11E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.74|P-value:3.14E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.74|P-value:1.19E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-4.13|P-value:2.63E-5 ID:SGTC_2744|Compound:captopril|FD-Score:3.81|P-value:2.48E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.04|P-value:1.04E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.77|P-value:2.83E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.33|P-value:5.15E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.74|P-value:3.14E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.67|P-value:1.58E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-4.09|P-value:3.05E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.90|P-value:1.78E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-4.77|P-value:1.69E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.77|P-value:2.80E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.83|P-value:2.24E-4

Top fitness defect scores for YOL145C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_382 3229-0966 6.45 23.2 µM 1.02E-9 1 5.41E-11
2 SGTC_794 k038-0031 6.13 316.0 µM 6.39E-9 ubiquinone biosynthesis & proteasome 55 4.33E-10
3 SGTC_1781 st038725 5.68 66.3 µM 7.22E-8 NEO1 61 6.76E-9
4 SGTC_2319 6033012 5.59 152.6 µM 1.11E-7 tubulin folding & SWR complex 16 1.10E-8
5 SGTC_1950 st077106 5.37 7.2 µM 3.49E-7 RNA processing & uracil transport 9 4.03E-8
6 SGTC_2393 9031399 5.34 185.9 µM 4.00E-7 RNA processing & uracil transport 9 4.71E-8
7 SGTC_25 0118-0223 4.80 35.7 µM 4.83E-6 4 7.97E-7
8 SGTC_1075 aripiprazole 4.72 15.2 µM 6.89E-6 12 1.19E-6
9 SGTC_2292 7671323 4.53 168.1 µM 1.53E-5 RNA processing & uracil transport 18 2.95E-6
10 SGTC_1360 1598-0022 4.44 39.8 µM 2.25E-5 ERG2 22 4.59E-6
11 SGTC_1656 st012921 4.41 11.0 µM 2.52E-5 23 5.22E-6
12 SGTC_1317 1273-0028 4.39 910.0 nM 2.71E-5 azole & statin 40 5.67E-6
13 SGTC_539 4859-0462 4.31 2.5 µM 3.72E-5 RNA pol III & RNase P/MRP 15 8.14E-6
14 SGTC_2495 cafestol 4.29 54.5 µM 4.11E-5 Golgi 21 9.11E-6
15 SGTC_1173 0443-0020 4.26 122.0 µM 4.51E-5 TSC3-RPN4 27 1.01E-5
16 SGTC_1623 st003709 4.22 20.3 µM 5.24E-5 calcium & mitochondrial duress 56 1.20E-5
17 SGTC_86 0417-1630 4.11 471.9 µM 8.26E-5 ubiquinone biosynthesis & proteasome 142 2.02E-5
18 SGTC_1754 st042065 4.05 16.1 µM 1.02E-4 NEO1-PIK1 169 2.57E-5
19 SGTC_2790 5423970 4.04 71.4 µM 1.04E-4 endomembrane recycling 68 2.63E-5
20 SGTC_1194 1488-0194 4.03 225.0 µM 1.08E-4 28 2.74E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.16E-28 YGL244W RTF1 hom Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
0.159 1.72E-20 YBR021W FUR4 hom Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
0.132 1.42E-14 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.131 3.02E-14 YLR418C CDC73 hom Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress
0.130 4.47E-14 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.124 5.22E-13 YDR469W SDC1 hom Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30
0.124 6.26E-13 YLR015W BRE2 hom Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
0.121 1.79E-12 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.118 6.79E-12 YBR175W SWD3 hom Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
0.117 1.14E-11 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.116 1.43E-11 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.114 3.60E-11 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.114 3.74E-11 YEL031W SPF1 hom P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
0.111 1.09E-10 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.109 2.74E-10 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)