YOL147C / PEX11

Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL147C / PEX11

Click on Significant Values for Screen Details ID:SGTC_322|Compound:k048-0136|FD-Score:3.07|P-value:4.46E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.62|P-value:4.43E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.16|P-value:3.11E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.52|P-value:6.77E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:5.42|P-value:2.22E-9 ID:SGTC_705|Compound:1124-0212|FD-Score:4.40|P-value:9.55E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:-2.94|P-value:7.19E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:4.36|P-value:1.15E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.95|P-value:9.36E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:-4.24|P-value:2.17E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:4.63|P-value:2.63E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.89|P-value:1.24E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.39|P-value:1.21E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:2.88|P-value:9.06E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.43|P-value:9.99E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.05|P-value:4.71E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:4.42|P-value:8.60E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:4.06|P-value:5.58E-6 ID:SGTC_1571|Compound:st070080|FD-Score:3.96|P-value:8.78E-6 ID:SGTC_1591|Compound:genipin|FD-Score:3.54|P-value:6.39E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.01|P-value:6.97E-6 ID:SGTC_1747|Compound:st037496|FD-Score:3.19|P-value:2.78E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.72|P-value:2.77E-5 ID:SGTC_1749|Compound:st037932|FD-Score:3.87|P-value:1.35E-5 ID:SGTC_1832|Compound:st054113|FD-Score:-2.93|P-value:7.46E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.13|P-value:3.45E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-2.86|P-value:9.84E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.73|P-value:2.63E-5 ID:SGTC_2071|Compound:5230951|FD-Score:-3.12|P-value:3.69E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-3.26|P-value:2.06E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.18|P-value:2.86E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.92|P-value:1.07E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:2.86|P-value:9.71E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.72|P-value:2.85E-5 ID:SGTC_2713|Compound:st079149|FD-Score:2.87|P-value:9.36E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.10|P-value:3.91E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.03|P-value:6.41E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:2.88|P-value:8.89E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.63|P-value:4.22E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-3.17|P-value:3.06E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.93|P-value:1.05E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.49|P-value:7.87E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.85|P-value:1.52E-5 ID:SGTC_2960|Compound:9079389|FD-Score:2.89|P-value:8.86E-4 ID:SGTC_3032|Compound:9089427|FD-Score:2.92|P-value:7.77E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.24|P-value:2.25E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-2.99|P-value:5.96E-4 ID:SGTC_3303|Compound:9125618|FD-Score:2.94|P-value:7.19E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.13|P-value:3.44E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.07|P-value:4.46E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.62|P-value:4.43E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.16|P-value:3.11E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.52|P-value:6.77E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:5.42|P-value:2.22E-9 ID:SGTC_705|Compound:1124-0212|FD-Score:4.40|P-value:9.55E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:-2.94|P-value:7.19E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:4.36|P-value:1.15E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.95|P-value:9.36E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:-4.24|P-value:2.17E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:4.63|P-value:2.63E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.89|P-value:1.24E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.39|P-value:1.21E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:2.88|P-value:9.06E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.43|P-value:9.99E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.05|P-value:4.71E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:4.42|P-value:8.60E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:4.06|P-value:5.58E-6 ID:SGTC_1571|Compound:st070080|FD-Score:3.96|P-value:8.78E-6 ID:SGTC_1591|Compound:genipin|FD-Score:3.54|P-value:6.39E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.01|P-value:6.97E-6 ID:SGTC_1747|Compound:st037496|FD-Score:3.19|P-value:2.78E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.72|P-value:2.77E-5 ID:SGTC_1749|Compound:st037932|FD-Score:3.87|P-value:1.35E-5 ID:SGTC_1832|Compound:st054113|FD-Score:-2.93|P-value:7.46E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.13|P-value:3.45E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-2.86|P-value:9.84E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.73|P-value:2.63E-5 ID:SGTC_2071|Compound:5230951|FD-Score:-3.12|P-value:3.69E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-3.26|P-value:2.06E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.18|P-value:2.86E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.92|P-value:1.07E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:2.86|P-value:9.71E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.72|P-value:2.85E-5 ID:SGTC_2713|Compound:st079149|FD-Score:2.87|P-value:9.36E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.10|P-value:3.91E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.03|P-value:6.41E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:2.88|P-value:8.89E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.63|P-value:4.22E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-3.17|P-value:3.06E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.93|P-value:1.05E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.49|P-value:7.87E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.85|P-value:1.52E-5 ID:SGTC_2960|Compound:9079389|FD-Score:2.89|P-value:8.86E-4 ID:SGTC_3032|Compound:9089427|FD-Score:2.92|P-value:7.77E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.24|P-value:2.25E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-2.99|P-value:5.96E-4 ID:SGTC_3303|Compound:9125618|FD-Score:2.94|P-value:7.19E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.13|P-value:3.44E-4

Top fitness defect scores for YOL147C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_663 1486-0733 5.42 13.9 µM 2.22E-9 cell wall signaling 26 3.03E-8
2 SGTC_1124 fisetin 4.63 1.2 µM 2.63E-7 16 1.82E-6
3 SGTC_1236 0330-0013 4.42 258.0 µM 8.60E-7 4 5.02E-6
4 SGTC_705 1124-0212 4.40 310.0 µM 9.55E-7 7 5.49E-6
5 SGTC_1102 cgs 12066b 4.36 26.1 µM 1.15E-6 endomembrane recycling 5 6.42E-6
6 SGTC_1568 digitonin 4.06 820.0 nM 5.58E-6 sphingolipid biosynthesis & PDR1 28 2.50E-5
7 SGTC_2755 lomerizine 4.03 42.7 µM 6.41E-6 23 2.81E-5
8 SGTC_1742 st038235 4.01 28.9 µM 6.97E-6 mitochondrial stress 112 3.02E-5
9 SGTC_1571 st070080 3.96 73.4 µM 8.78E-6 18 3.69E-5
10 SGTC_2807 7945238 3.93 52.0 µM 1.05E-5 23 4.28E-5
11 SGTC_2454 5-benzylidenerhodanine 3.92 10.4 µM 1.07E-5 TRP & mitochondrial translation 40 4.35E-5
12 SGTC_1128 3448-9350 3.89 235.0 µM 1.24E-5 24 4.96E-5
13 SGTC_1749 st037932 3.87 54.2 µM 1.35E-5 29 5.34E-5
14 SGTC_1996 st072960 3.73 66.8 µM 2.63E-5 21 9.46E-5
15 SGTC_1748 st037455 3.72 53.6 µM 2.77E-5 37 9.88E-5
16 SGTC_2701 st077767 3.72 14.7 µM 2.85E-5 52 1.01E-4
17 SGTC_2772 vinpocetine 3.63 57.1 µM 4.22E-5 33 1.42E-4
18 SGTC_1591 genipin 3.54 88.4 µM 6.39E-5 mitochondrial processes 24 2.03E-4
19 SGTC_552 k242-0005 3.52 476.0 µM 6.77E-5 30 2.13E-4
20 SGTC_2921 7974240 3.49 10.7 µM 7.87E-5 74 2.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.32E-16 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.118 8.59E-12 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.112 7.46E-11 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.112 8.12E-11 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.104 1.49E-9 YPR174C YPR174C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication
0.100 6.62E-9 YCL024W KCC4 hom Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication
0.097 1.77E-8 YER158C_p YER158C_p hom Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication
0.097 1.99E-8 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.096 2.30E-8 YBR119W MUD1 hom U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing
0.096 2.52E-8 YLR049C_p YLR049C_p hom Putative protein of unknown function
0.094 5.06E-8 YLR108C YLR108C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication
0.093 7.65E-8 YMR238W DFG5 hom Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
0.092 1.01E-7 YML059C NTE1 hom Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes
0.092 1.12E-7 YFR018C_p YFR018C_p hom Putative protein of unknown function
0.089 2.32E-7 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication