YOL149W / DCP1

Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOL149W / DCP1

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:3.77|P-value:1.04E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.86|P-value:7.59E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.29|P-value:6.20E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.25|P-value:7.16E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.44|P-value:3.63E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:10.30|P-value:1.88E-24 ID:SGTC_879|Compound:0831-1030|FD-Score:4.90|P-value:7.41E-7 ID:SGTC_924|Compound:2046-0044|FD-Score:3.76|P-value:1.10E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.39|P-value:8.17E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.48|P-value:3.18E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.21|P-value:8.08E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.45|P-value:3.57E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.52|P-value:2.72E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.82|P-value:8.94E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.46|P-value:3.32E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.53|P-value:2.57E-4 ID:SGTC_2306|Compound:7482397|FD-Score:6.31|P-value:2.91E-10 ID:SGTC_2371|Compound:9071574|FD-Score:3.40|P-value:4.19E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.51|P-value:2.87E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.48|P-value:3.17E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.96|P-value:4.98E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.70|P-value:1.39E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.32|P-value:5.55E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.19|P-value:1.91E-5 ID:SGTC_3137|Compound:9097352|FD-Score:3.39|P-value:4.39E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.21|P-value:8.03E-4 ID:SGTC_3170|Compound:9103054|FD-Score:4.36|P-value:9.35E-6 ID:SGTC_3171|Compound:9103192|FD-Score:3.63|P-value:1.80E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:3.77|P-value:1.04E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.86|P-value:7.59E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.29|P-value:6.20E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.25|P-value:7.16E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.44|P-value:3.63E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:10.30|P-value:1.88E-24 ID:SGTC_879|Compound:0831-1030|FD-Score:4.90|P-value:7.41E-7 ID:SGTC_924|Compound:2046-0044|FD-Score:3.76|P-value:1.10E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.39|P-value:8.17E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.48|P-value:3.18E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.21|P-value:8.08E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.45|P-value:3.57E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.52|P-value:2.72E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.82|P-value:8.94E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.46|P-value:3.32E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.53|P-value:2.57E-4 ID:SGTC_2306|Compound:7482397|FD-Score:6.31|P-value:2.91E-10 ID:SGTC_2371|Compound:9071574|FD-Score:3.40|P-value:4.19E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.51|P-value:2.87E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.48|P-value:3.17E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.96|P-value:4.98E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.70|P-value:1.39E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.32|P-value:5.55E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.19|P-value:1.91E-5 ID:SGTC_3137|Compound:9097352|FD-Score:3.39|P-value:4.39E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.21|P-value:8.03E-4 ID:SGTC_3170|Compound:9103054|FD-Score:4.36|P-value:9.35E-6 ID:SGTC_3171|Compound:9103192|FD-Score:3.63|P-value:1.80E-4

Top fitness defect scores for YOL149W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_878 0828-0289 10.30 13.7 µM 1.88E-24 5 2.89E-25 0.99
2 SGTC_2306 7482397 6.31 179.5 µM 2.91E-10 RPP1 & pyrimidine depletion 5 1.43E-10 1.66
3 SGTC_879 0831-1030 4.90 162.0 µM 7.41E-7 9 4.80E-7 0.12
4 SGTC_1056 3448-1962 4.39 115.0 µM 8.17E-6 amide catabolism 5 5.75E-6 0.40
5 SGTC_3170 9103054 4.36 49.5 µM 9.35E-6 60S ribosome export 5 6.62E-6 0.85
6 SGTC_3089 9117425 4.19 49.5 µM 1.91E-5 1 1.39E-5 0.57
7 SGTC_314 1671-0008 3.86 2.7 µM 7.59E-5 9 5.77E-5 0.05
8 SGTC_5 0352-0601 3.77 109.9 µM 1.04E-4 ERG2 3 8.02E-5 0.01
9 SGTC_924 2046-0044 3.76 21.3 µM 1.10E-4 9 8.47E-5 0.28
10 SGTC_2721 ifenprodil 3.70 61.4 µM 1.39E-4 plasma membrane duress 8 1.08E-4 0.04
11 SGTC_3171 9103192 3.63 49.5 µM 1.80E-4 4 1.41E-4 0.23
12 SGTC_1975 st070967 3.53 30.8 µM 2.57E-4 15 2.04E-4 0.10
13 SGTC_1597 7-benzyloxygramine 3.52 47.5 µM 2.72E-4 calcium & mitochondrial duress 60 2.16E-4 0.06
14 SGTC_2492 derrusnin 3.51 100.0 µM 2.87E-4 6 2.28E-4 0.15
15 SGTC_2597 laccaic acid a 3.48 100.0 µM 3.17E-4 10 2.53E-4 0.13
16 SGTC_1129 3453-1384 3.48 223.0 µM 3.18E-4 22 2.54E-4 0.00
17 SGTC_1959 st077091 3.46 55.8 µM 3.32E-4 RPP1 & pyrimidine depletion 30 2.65E-4 0.02
18 SGTC_2371 9071574 3.40 200.0 µM 4.19E-4 6 3.38E-4 0.10
19 SGTC_3137 9097352 3.39 49.5 µM 4.39E-4 13 3.55E-4 0.01
20 SGTC_2772 vinpocetine 3.32 57.1 µM 5.55E-4 12 4.52E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 9.34E-28 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.153 4.39E-19 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.147 8.79E-18 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.126 2.15E-13 YLR282C_d YLR282C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
0.125 3.21E-13 YPR103W PRE2 het Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
0.123 7.34E-13 YDR059C UBC5 hom Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication
0.116 1.61E-11 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.106 7.68E-10 YKL012W PRP40 het U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
0.102 3.41E-9 YDR472W TRS31 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.102 3.58E-9 YMR156C TPP1 hom DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase
0.101 4.07E-9 YKL040C NFU1 hom Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
0.100 6.19E-9 YPL185W_d YPL185W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
0.098 1.34E-8 YML077W BET5 het Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
0.097 1.75E-8 YNL130C CPT1 hom Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication
0.097 1.77E-8 YAR027W UIP3 hom Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family