YOL150C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL150C / YOL150C

Click on Significant Values for Screen Details ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.23|P-value:3.24E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.69|P-value:4.83E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.76|P-value:3.68E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:2.99|P-value:8.00E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.52|P-value:9.49E-7 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.76|P-value:3.67E-5 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.22|P-value:3.47E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.17|P-value:4.12E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-4.67|P-value:4.19E-7 ID:SGTC_1739|Compound:st037196|FD-Score:-3.03|P-value:6.96E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.11|P-value:5.16E-4 ID:SGTC_1845|Compound:st056753|FD-Score:-3.94|P-value:1.58E-5 ID:SGTC_1846|Compound:st056244|FD-Score:-3.82|P-value:2.72E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-4.46|P-value:1.28E-6 ID:SGTC_1852|Compound:st056254|FD-Score:9.27|P-value:6.84E-23 ID:SGTC_1856|Compound:st057054|FD-Score:7.39|P-value:3.11E-15 ID:SGTC_1859|Compound:st055998|FD-Score:3.72|P-value:4.29E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.13|P-value:4.69E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.10|P-value:7.61E-6 ID:SGTC_1913|Compound:st060213|FD-Score:-3.36|P-value:1.98E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.29|P-value:2.61E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.34|P-value:2.13E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.23|P-value:4.09E-6 ID:SGTC_2429|Compound:5902844|FD-Score:3.56|P-value:8.57E-5 ID:SGTC_2707|Compound:st078556|FD-Score:3.43|P-value:1.48E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.06|P-value:6.26E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.65|P-value:5.79E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-3.25|P-value:2.97E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.23|P-value:3.24E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.69|P-value:4.83E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.76|P-value:3.68E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:2.99|P-value:8.00E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.52|P-value:9.49E-7 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.76|P-value:3.67E-5 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.22|P-value:3.47E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.17|P-value:4.12E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-4.67|P-value:4.19E-7 ID:SGTC_1739|Compound:st037196|FD-Score:-3.03|P-value:6.96E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.11|P-value:5.16E-4 ID:SGTC_1845|Compound:st056753|FD-Score:-3.94|P-value:1.58E-5 ID:SGTC_1846|Compound:st056244|FD-Score:-3.82|P-value:2.72E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-4.46|P-value:1.28E-6 ID:SGTC_1852|Compound:st056254|FD-Score:9.27|P-value:6.84E-23 ID:SGTC_1856|Compound:st057054|FD-Score:7.39|P-value:3.11E-15 ID:SGTC_1859|Compound:st055998|FD-Score:3.72|P-value:4.29E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.13|P-value:4.69E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.10|P-value:7.61E-6 ID:SGTC_1913|Compound:st060213|FD-Score:-3.36|P-value:1.98E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.29|P-value:2.61E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.34|P-value:2.13E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.23|P-value:4.09E-6 ID:SGTC_2429|Compound:5902844|FD-Score:3.56|P-value:8.57E-5 ID:SGTC_2707|Compound:st078556|FD-Score:3.43|P-value:1.48E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.06|P-value:6.26E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.65|P-value:5.79E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-3.25|P-value:2.97E-4

Top fitness defect scores for YOL150C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1852 st056254 9.27 31.4 µM 6.84E-23 1 9.29E-21
2 SGTC_1856 st057054 7.39 55.7 µM 3.11E-15 1 7.17E-14
3 SGTC_1262 0737-0114 4.52 49.6 µM 9.49E-7 8 3.15E-6
4 SGTC_2425 5628681 4.23 7.8 µM 4.09E-6 15 1.18E-5
5 SGTC_1911 st060208 4.10 74.3 µM 7.61E-6 31 2.06E-5
6 SGTC_1412 3909-8563 3.76 178.0 µM 3.67E-5 11 8.53E-5
7 SGTC_1859 st055998 3.72 20.0 µM 4.29E-5 34 9.81E-5
8 SGTC_2429 5902844 3.56 64.4 µM 8.57E-5 39 1.84E-4
9 SGTC_2707 st078556 3.43 66.6 µM 1.48E-4 21 3.00E-4
10 SGTC_2356 9061756 3.34 189.0 µM 2.13E-4 21 4.18E-4
11 SGTC_1431 4049-0260 3.22 9.1 µM 3.47E-4 21 6.51E-4
12 SGTC_1726 st035556 3.17 14.6 µM 4.12E-4 78 7.59E-4
13 SGTC_909 3448-9333 2.99 149.0 µM 8.00E-4 46 0.00139
14 SGTC_1241 0364-0022 2.90 50.8 µM 0.00109 ERG2 87 0.00184
15 SGTC_1254 0550-0035 2.89 264.0 µM 0.00116 70 0.00194
16 SGTC_3295 9122362 2.87 53.6 µM 0.00125 60 0.00207
17 SGTC_743 1275-0778 2.83 158.0 µM 0.00144 excess fatty acid 109 0.00236
18 SGTC_1221 2958-7315 2.81 257.0 µM 0.00152 58 0.00247
19 SGTC_966 1300-0360 2.80 30.2 µM 0.00158 heme requiring 86 0.00257
20 SGTC_1929 genistein trimethyl ether 2.78 50.5 µM 0.00167 66 0.00270

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.24E-17 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.128 1.24E-13 YOL010W RCL1 het Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
0.117 1.15E-11 YGR274C TAF1 het TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
0.104 1.78E-9 YHR207C SET5 hom Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus
0.101 5.53E-9 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.098 1.11E-8 YKR033C_d YKR033C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
0.097 2.13E-8 YHL013C OTU2 hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress
0.094 4.72E-8 YGL138C_p YGL138C_p hom Putative protein of unknown function; has no significant sequence similarity to any known protein
0.093 5.90E-8 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.093 6.13E-8 YKL161C KDX1 hom Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p
0.090 1.77E-7 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.086 6.02E-7 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.085 8.37E-7 YFL052W_p YFL052W_p hom Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity
0.084 9.80E-7 YGL154C LYS5 hom Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
0.084 1.11E-6 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation