YOL152W / FRE7

Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL152W / FRE7

Click on Significant Values for Screen Details ID:SGTC_361|Compound:000s-0510|FD-Score:-3.39|P-value:3.43E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.52|P-value:3.31E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.43|P-value:3.24E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.23|P-value:5.95E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-4.61|P-value:1.94E-6 ID:SGTC_519|Compound:k048-0011|FD-Score:-5.44|P-value:2.62E-8 ID:SGTC_520|Compound:3584-0023|FD-Score:3.66|P-value:1.34E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.33|P-value:4.18E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.35|P-value:4.31E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.73|P-value:9.31E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:-3.99|P-value:3.21E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:3.26|P-value:5.86E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.56|P-value:2.01E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.54|P-value:3.09E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:7.25|P-value:2.48E-13 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.55|P-value:2.02E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:5.18|P-value:1.26E-7 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.74|P-value:1.20E-6 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.53|P-value:2.21E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.46|P-value:4.48E-6 ID:SGTC_1766|Compound:st045414|FD-Score:3.55|P-value:2.03E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.26|P-value:5.95E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.28|P-value:5.58E-4 ID:SGTC_1917|Compound:st066507|FD-Score:8.91|P-value:3.04E-19 ID:SGTC_2053|Compound:5265679|FD-Score:3.90|P-value:5.22E-5 ID:SGTC_2317|Compound:5986382|FD-Score:3.15|P-value:8.51E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.51|P-value:2.35E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.39|P-value:3.76E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.92|P-value:4.28E-7 ID:SGTC_2780|Compound:5215298|FD-Score:3.17|P-value:7.93E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-3.35|P-value:3.99E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.40|P-value:3.52E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-3.59|P-value:1.60E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.56|P-value:1.80E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.18|P-value:7.08E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.13|P-value:9.30E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.05|P-value:2.76E-5 ID:SGTC_3261|Compound:9137475|FD-Score:-3.16|P-value:7.71E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.76|P-value:9.06E-5 ID:SGTC_3277|Compound:9138724|FD-Score:-3.29|P-value:4.91E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.32|P-value:4.32E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.23|P-value:6.59E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.26|P-value:5.84E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.39|P-value:3.43E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.52|P-value:3.31E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.43|P-value:3.24E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.23|P-value:5.95E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-4.61|P-value:1.94E-6 ID:SGTC_519|Compound:k048-0011|FD-Score:-5.44|P-value:2.62E-8 ID:SGTC_520|Compound:3584-0023|FD-Score:3.66|P-value:1.34E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.33|P-value:4.18E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.35|P-value:4.31E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.73|P-value:9.31E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:-3.99|P-value:3.21E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:3.26|P-value:5.86E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.56|P-value:2.01E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.54|P-value:3.09E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:7.25|P-value:2.48E-13 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.55|P-value:2.02E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:5.18|P-value:1.26E-7 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.74|P-value:1.20E-6 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.53|P-value:2.21E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.46|P-value:4.48E-6 ID:SGTC_1766|Compound:st045414|FD-Score:3.55|P-value:2.03E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.26|P-value:5.95E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.28|P-value:5.58E-4 ID:SGTC_1917|Compound:st066507|FD-Score:8.91|P-value:3.04E-19 ID:SGTC_2053|Compound:5265679|FD-Score:3.90|P-value:5.22E-5 ID:SGTC_2317|Compound:5986382|FD-Score:3.15|P-value:8.51E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.51|P-value:2.35E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.39|P-value:3.76E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.92|P-value:4.28E-7 ID:SGTC_2780|Compound:5215298|FD-Score:3.17|P-value:7.93E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-3.35|P-value:3.99E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.40|P-value:3.52E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-3.59|P-value:1.60E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.56|P-value:1.80E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.18|P-value:7.08E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.13|P-value:9.30E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.05|P-value:2.76E-5 ID:SGTC_3261|Compound:9137475|FD-Score:-3.16|P-value:7.71E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.76|P-value:9.06E-5 ID:SGTC_3277|Compound:9138724|FD-Score:-3.29|P-value:4.91E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.32|P-value:4.32E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.23|P-value:6.59E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.26|P-value:5.84E-4

Top fitness defect scores for YOL152W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1917 st066507 8.91 28.5 µM 3.04E-19 Golgi 4 2.45E-19
2 SGTC_1260 0700-1617 7.25 7.8 µM 2.48E-13 calcium & mitochondrial duress 5 2.11E-13
3 SGTC_1356 1502-0781 5.18 85.8 µM 1.26E-7 fatty acid desaturase (OLE1) 5 1.14E-7
4 SGTC_1363 1636-0063 4.74 10.4 µM 1.20E-6 Golgi 14 1.09E-6
5 SGTC_1129 3453-1384 4.54 223.0 µM 3.09E-6 25 2.84E-6
6 SGTC_367 0335-0881 4.52 7.1 µM 3.31E-6 ubiquinone biosynthesis & proteasome 56 3.04E-6
7 SGTC_1728 st035614 4.46 33.8 µM 4.48E-6 29 4.12E-6
8 SGTC_3189 9110682 4.05 49.5 µM 2.76E-5 35 2.56E-5
9 SGTC_2053 5265679 3.90 138.0 µM 5.22E-5 25 4.87E-5
10 SGTC_3267 9137951 3.76 49.5 µM 9.06E-5 7 8.47E-5
11 SGTC_520 3584-0023 3.66 682.0 µM 1.34E-4 31 1.25E-4
12 SGTC_1002 4049-0206 3.56 172.0 µM 2.01E-4 50 1.88E-4
13 SGTC_1265 0819-1001 3.55 68.8 µM 2.02E-4 33 1.90E-4
14 SGTC_1766 st045414 3.55 44.8 µM 2.03E-4 RPP1 & pyrimidine depletion 44 1.90E-4
15 SGTC_1489 4065-0444 3.53 182.0 µM 2.21E-4 31 2.08E-4
16 SGTC_2383 9036125 3.51 200.0 µM 2.35E-4 11 2.21E-4
17 SGTC_409 arachidonic acid 3.43 100.0 µM 3.24E-4 29 3.05E-4
18 SGTC_2943 9068529 3.40 45.3 µM 3.52E-4 39 3.32E-4
19 SGTC_2471 5466956 3.39 24.8 µM 3.76E-4 mitochondrial processes 22 3.54E-4
20 SGTC_638 3970-0837 3.35 4.1 µM 4.31E-4 67 4.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 4.31E-11 YLR433C CNA1 hom Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.111 9.58E-11 YPL147W PXA1 hom Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
0.108 3.95E-10 YLR142W PUT1 hom Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
0.105 1.04E-9 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.103 2.17E-9 YKR005C_p YKR005C_p hom Putative protein of unknown function
0.102 3.29E-9 YIL155C GUT2 hom Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
0.096 2.35E-8 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.094 4.71E-8 YPR067W ISA2 hom Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
0.094 5.52E-8 YJL147C_p YJL147C_p hom Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
0.092 8.78E-8 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.092 9.68E-8 YFR046C CNN1 hom Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T
0.090 1.98E-7 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.087 5.89E-7 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.086 5.78E-7 YNL193W_p YNL193W_p hom Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
0.086 6.81E-7 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport