YOL153C

Hypothetical protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL153C / YOL153C

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:-3.56|P-value:2.40E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:-4.15|P-value:1.06E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:-4.22|P-value:6.86E-7 ID:SGTC_264|Compound:promethazine|FD-Score:-5.40|P-value:3.37E-10 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-5.50|P-value:1.62E-10 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.17|P-value:1.47E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.66|P-value:1.29E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:2.92|P-value:3.96E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.04|P-value:2.64E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.24|P-value:9.66E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.28|P-value:8.20E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.73|P-value:8.96E-6 ID:SGTC_1322|Compound:1348-1070|FD-Score:2.84|P-value:5.54E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.08|P-value:2.21E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.63|P-value:1.54E-5 ID:SGTC_1665|Compound:st014639|FD-Score:-3.18|P-value:1.44E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:2.74|P-value:8.22E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.99|P-value:2.33E-6 ID:SGTC_2011|Compound:4012611|FD-Score:3.61|P-value:1.66E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-2.71|P-value:9.90E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.23|P-value:1.02E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-2.73|P-value:9.06E-4 ID:SGTC_2322|Compound:7413319|FD-Score:2.76|P-value:7.47E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.27|P-value:4.83E-7 ID:SGTC_2328|Compound:6201408|FD-Score:-2.81|P-value:6.79E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.35|P-value:5.84E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.80|P-value:2.04E-8 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.88|P-value:4.19E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.06|P-value:1.56E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-2.86|P-value:5.55E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:-2.92|P-value:4.22E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.80|P-value:6.22E-6 ID:SGTC_2797|Compound:7859098|FD-Score:3.68|P-value:1.18E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-2.80|P-value:6.90E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.35|P-value:6.51E-5 ID:SGTC_2880|Compound:9042983|FD-Score:4.02|P-value:1.90E-6 ID:SGTC_2929|Compound:9013348|FD-Score:3.99|P-value:2.27E-6 ID:SGTC_3193|Compound:9111931|FD-Score:2.91|P-value:4.05E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.10|P-value:1.82E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.56|P-value:2.40E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:-4.15|P-value:1.06E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:-4.22|P-value:6.86E-7 ID:SGTC_264|Compound:promethazine|FD-Score:-5.40|P-value:3.37E-10 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-5.50|P-value:1.62E-10 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.17|P-value:1.47E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.66|P-value:1.29E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:2.92|P-value:3.96E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.04|P-value:2.64E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.24|P-value:9.66E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.28|P-value:8.20E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.73|P-value:8.96E-6 ID:SGTC_1322|Compound:1348-1070|FD-Score:2.84|P-value:5.54E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.08|P-value:2.21E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.63|P-value:1.54E-5 ID:SGTC_1665|Compound:st014639|FD-Score:-3.18|P-value:1.44E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:2.74|P-value:8.22E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.99|P-value:2.33E-6 ID:SGTC_2011|Compound:4012611|FD-Score:3.61|P-value:1.66E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-2.71|P-value:9.90E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.23|P-value:1.02E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-2.73|P-value:9.06E-4 ID:SGTC_2322|Compound:7413319|FD-Score:2.76|P-value:7.47E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.27|P-value:4.83E-7 ID:SGTC_2328|Compound:6201408|FD-Score:-2.81|P-value:6.79E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.35|P-value:5.84E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.80|P-value:2.04E-8 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.88|P-value:4.19E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.06|P-value:1.56E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-2.86|P-value:5.55E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:-2.92|P-value:4.22E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.80|P-value:6.22E-6 ID:SGTC_2797|Compound:7859098|FD-Score:3.68|P-value:1.18E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-2.80|P-value:6.90E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.35|P-value:6.51E-5 ID:SGTC_2880|Compound:9042983|FD-Score:4.02|P-value:1.90E-6 ID:SGTC_2929|Compound:9013348|FD-Score:3.99|P-value:2.27E-6 ID:SGTC_3193|Compound:9111931|FD-Score:2.91|P-value:4.05E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.10|P-value:1.82E-4

Top fitness defect scores for YOL153C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2327 6189656 4.27 200.0 µM 4.83E-7 16 9.99E-6
2 SGTC_2581 avocatin a 4.06 64.0 µM 1.56E-6 sphingolipid biosynthesis & PDR1 49 2.46E-5
3 SGTC_2880 9042983 4.02 58.4 µM 1.90E-6 fatty acid desaturase (OLE1) 22 2.86E-5
4 SGTC_2929 9013348 3.99 24.6 µM 2.27E-6 17 3.28E-5
5 SGTC_1879 gemcitabine 3.99 100.0 µM 2.33E-6 13 3.34E-5
6 SGTC_2538 3',7'-epoxycaryophyllan-6-one 3.88 100.0 µM 4.19E-6 24 5.26E-5
7 SGTC_2766 oltipraz 3.80 83.9 µM 6.22E-6 heme requiring 28 7.13E-5
8 SGTC_1084 voriconazole 3.73 435.0 nM 8.96E-6 azole & statin 32 9.44E-5
9 SGTC_2797 7859098 3.68 81.8 µM 1.18E-5 34 1.17E-4
10 SGTC_431 k089-0097 3.66 107.0 µM 1.29E-5 iron homeostasis 58 1.25E-4
11 SGTC_1645 Cervolide 3.63 78.0 µM 1.54E-5 9 1.43E-4
12 SGTC_2011 4012611 3.61 177.0 µM 1.66E-5 mitochondrial processes 41 1.52E-4
13 SGTC_2528 xanthyletin 3.35 44.8 µM 5.84E-5 36 4.00E-4
14 SGTC_1003 4049-0218 3.28 100.0 µM 8.20E-5 47 5.20E-4
15 SGTC_944 3370-0224 3.24 231.0 µM 9.66E-5 56 5.90E-4
16 SGTC_2163 5671233 3.23 125.0 µM 1.02E-4 49 6.15E-4
17 SGTC_3220 9131269 3.10 49.5 µM 1.82E-4 31 9.65E-4
18 SGTC_537 1334-0398 2.92 209.0 µM 3.96E-4 73 0.00176
19 SGTC_3193 9111931 2.91 49.5 µM 4.05E-4 72 0.00179
20 SGTC_1322 1348-1070 2.84 12.0 µM 5.54E-4 38 0.00228

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.36E-20 YMR305C SCW10 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
0.147 9.61E-18 YGL192W IME4 hom Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids
0.112 7.27E-11 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.102 3.81E-9 YGR152C RSR1 hom GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
0.100 7.58E-9 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.099 7.86E-9 YJR044C VPS55 hom Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)
0.098 1.48E-8 YKR058W GLG1 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication
0.096 2.26E-8 YKL046C DCW1 hom Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
0.096 2.76E-8 YDR274C_d YDR274C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 5.85E-8 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.088 3.22E-7 YJL131C AIM23 hom Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss
0.088 3.28E-7 YGR125W_p YGR125W_p hom Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.088 3.61E-7 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.084 1.05E-6 YNL094W APP1 hom Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway
0.081 2.61E-6 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress