YOL155C / HPF1

Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL155C / HPF1

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:-3.57|P-value:3.06E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:4.31|P-value:1.68E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.12|P-value:3.71E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.48|P-value:4.03E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.61|P-value:2.57E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:5.58|P-value:4.13E-8 ID:SGTC_406|Compound:estrone|FD-Score:3.76|P-value:1.50E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.41|P-value:5.19E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.39|P-value:5.58E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.24|P-value:2.32E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:3.82|P-value:1.20E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-4.12|P-value:3.78E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:4.69|P-value:3.24E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:3.46|P-value:4.41E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:5.28|P-value:1.97E-7 ID:SGTC_946|Compound:3434-1334|FD-Score:3.54|P-value:3.34E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.89|P-value:9.34E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.22|P-value:2.49E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.56|P-value:3.10E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.33|P-value:1.59E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.42|P-value:5.04E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-5.07|P-value:5.64E-7 ID:SGTC_1727|Compound:st034309|FD-Score:6.90|P-value:1.61E-11 ID:SGTC_1791|Compound:st048313|FD-Score:3.96|P-value:7.01E-5 ID:SGTC_2082|Compound:5219693|FD-Score:3.53|P-value:3.43E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.35|P-value:6.32E-4 ID:SGTC_2137|Compound:5261020|FD-Score:5.81|P-value:1.18E-8 ID:SGTC_2200|Compound:6600604|FD-Score:4.33|P-value:1.54E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.54|P-value:3.35E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.22|P-value:9.62E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.26|P-value:8.81E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.39|P-value:5.59E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.60|P-value:2.65E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.41|P-value:1.12E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-3.30|P-value:7.76E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.51|P-value:3.70E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.85|P-value:1.06E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.34|P-value:6.61E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.52|P-value:3.54E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.20|P-value:2.69E-5 ID:SGTC_3214|Compound:9129694|FD-Score:-4.11|P-value:3.91E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-3.80|P-value:1.29E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.94|P-value:7.56E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.37|P-value:5.93E-4 ID:SGTC_3316|Compound:9136639|FD-Score:4.02|P-value:5.55E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.57|P-value:3.06E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:4.31|P-value:1.68E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.12|P-value:3.71E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.48|P-value:4.03E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.61|P-value:2.57E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:5.58|P-value:4.13E-8 ID:SGTC_406|Compound:estrone|FD-Score:3.76|P-value:1.50E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.41|P-value:5.19E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.39|P-value:5.58E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.24|P-value:2.32E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:3.82|P-value:1.20E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-4.12|P-value:3.78E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:4.69|P-value:3.24E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:3.46|P-value:4.41E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:5.28|P-value:1.97E-7 ID:SGTC_946|Compound:3434-1334|FD-Score:3.54|P-value:3.34E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.89|P-value:9.34E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.22|P-value:2.49E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.56|P-value:3.10E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.33|P-value:1.59E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.42|P-value:5.04E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-5.07|P-value:5.64E-7 ID:SGTC_1727|Compound:st034309|FD-Score:6.90|P-value:1.61E-11 ID:SGTC_1791|Compound:st048313|FD-Score:3.96|P-value:7.01E-5 ID:SGTC_2082|Compound:5219693|FD-Score:3.53|P-value:3.43E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.35|P-value:6.32E-4 ID:SGTC_2137|Compound:5261020|FD-Score:5.81|P-value:1.18E-8 ID:SGTC_2200|Compound:6600604|FD-Score:4.33|P-value:1.54E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.54|P-value:3.35E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.22|P-value:9.62E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.26|P-value:8.81E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.39|P-value:5.59E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.60|P-value:2.65E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.41|P-value:1.12E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-3.30|P-value:7.76E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.51|P-value:3.70E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.85|P-value:1.06E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.34|P-value:6.61E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.52|P-value:3.54E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.20|P-value:2.69E-5 ID:SGTC_3214|Compound:9129694|FD-Score:-4.11|P-value:3.91E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-3.80|P-value:1.29E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.94|P-value:7.56E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.37|P-value:5.93E-4 ID:SGTC_3316|Compound:9136639|FD-Score:4.02|P-value:5.55E-5

Top fitness defect scores for YOL155C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1727 st034309 6.90 9.9 µM 1.61E-11 3 2.54E-12
2 SGTC_2137 5261020 5.81 140.0 µM 1.18E-8 14 3.17E-9
3 SGTC_400 oxethazaine 5.58 37.5 µM 4.13E-8 calcium & mitochondrial duress 5 1.23E-8
4 SGTC_768 0384-0033 5.28 77.3 µM 1.97E-7 fatty acid desaturase (OLE1) 48 6.64E-8
5 SGTC_724 3910-0327 4.69 137.0 µM 3.24E-6 ERG2 11 1.36E-6
6 SGTC_2823 7987624 4.41 58.4 µM 1.12E-5 17 5.17E-6
7 SGTC_2200 6600604 4.33 21.9 µM 1.54E-5 tubulin folding & SWR complex 44 7.32E-6
8 SGTC_1597 7-benzyloxygramine 4.33 47.5 µM 1.59E-5 calcium & mitochondrial duress 96 7.58E-6
9 SGTC_139 0099-0334 4.31 718.6 µM 1.68E-5 18 8.06E-6
10 SGTC_655 k060-0012 4.24 42.0 µM 2.32E-5 8 1.14E-5
11 SGTC_1146 3579-1023 4.22 7.0 µM 2.49E-5 9 1.23E-5
12 SGTC_3149 9097855 4.20 49.5 µM 2.69E-5 Golgi 22 1.34E-5
13 SGTC_142 0335-0849 4.12 62.7 µM 3.71E-5 ubiquinone biosynthesis & proteasome 116 1.89E-5
14 SGTC_3316 9136639 4.02 10.6 µM 5.55E-5 11 2.92E-5
15 SGTC_1791 st048313 3.96 56.1 µM 7.01E-5 14 3.75E-5
16 SGTC_3302 9125395 3.94 16.4 µM 7.56E-5 10 4.07E-5
17 SGTC_1022 4477-0945 3.89 21.3 µM 9.34E-5 25 5.11E-5
18 SGTC_3055 9094636 3.85 49.5 µM 1.06E-4 11 5.84E-5
19 SGTC_660 4031-1742 3.82 102.0 µM 1.20E-4 redox potentiating 52 6.70E-5
20 SGTC_406 estrone 3.76 100.0 µM 1.50E-4 12 8.53E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 7.48E-12 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.102 2.87E-9 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.095 4.11E-8 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.092 1.05E-7 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.086 6.64E-7 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.084 1.26E-6 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.083 1.52E-6 YLR379W_d YLR379W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C
0.083 1.67E-6 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.080 3.53E-6 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.079 4.12E-6 YKR020W VPS51 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p
0.079 4.81E-6 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.077 8.89E-6 YLR404W FLD1 hom Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy
0.075 1.26E-5 YGR098C ESP1 het Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress
0.075 1.45E-5 YPR089W_p YPR089W_p hom Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p
0.074 1.72E-5 YBR161W CSH1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication