YOL160W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL160W / YOL160W

Click on Significant Values for Screen Details ID:SGTC_166|Compound:k072-0058|FD-Score:-2.71|P-value:6.20E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.13|P-value:9.53E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:2.63|P-value:9.71E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.78|P-value:5.38E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.87|P-value:3.05E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-2.65|P-value:7.74E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.84|P-value:3.59E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.27|P-value:4.78E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:2.74|P-value:6.20E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.57|P-value:1.26E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:3.36|P-value:3.74E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:2.69|P-value:7.53E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.34|P-value:4.03E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:-2.64|P-value:8.30E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:4.95|P-value:2.48E-9 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.16|P-value:4.42E-7 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.58|P-value:1.23E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.09|P-value:1.16E-4 ID:SGTC_1741|Compound:st038134|FD-Score:6.27|P-value:6.31E-14 ID:SGTC_1748|Compound:st037455|FD-Score:3.96|P-value:1.48E-6 ID:SGTC_1908|Compound:st060353|FD-Score:3.07|P-value:1.49E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.67|P-value:7.53E-6 ID:SGTC_2014|Compound:4013930|FD-Score:3.69|P-value:6.66E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-2.83|P-value:3.69E-4 ID:SGTC_2411|Compound:st077133|FD-Score:2.93|P-value:2.78E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.51|P-value:1.75E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.40|P-value:2.98E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:3.16|P-value:9.61E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.80|P-value:4.91E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.75|P-value:4.86E-6 ID:SGTC_2692|Compound:st077426|FD-Score:3.24|P-value:6.53E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.35|P-value:3.80E-5 ID:SGTC_2706|Compound:st078239|FD-Score:-2.61|P-value:9.31E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-2.93|P-value:2.33E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-2.61|P-value:9.11E-4 ID:SGTC_3163|Compound:9099914|FD-Score:-2.82|P-value:3.80E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.14|P-value:1.06E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-2.84|P-value:3.52E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.71|P-value:6.20E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.13|P-value:9.53E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:2.63|P-value:9.71E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.78|P-value:5.38E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.87|P-value:3.05E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-2.65|P-value:7.74E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.84|P-value:3.59E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.27|P-value:4.78E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:2.74|P-value:6.20E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.57|P-value:1.26E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:3.36|P-value:3.74E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:2.69|P-value:7.53E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.34|P-value:4.03E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:-2.64|P-value:8.30E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:4.95|P-value:2.48E-9 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.16|P-value:4.42E-7 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.58|P-value:1.23E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.09|P-value:1.16E-4 ID:SGTC_1741|Compound:st038134|FD-Score:6.27|P-value:6.31E-14 ID:SGTC_1748|Compound:st037455|FD-Score:3.96|P-value:1.48E-6 ID:SGTC_1908|Compound:st060353|FD-Score:3.07|P-value:1.49E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.67|P-value:7.53E-6 ID:SGTC_2014|Compound:4013930|FD-Score:3.69|P-value:6.66E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-2.83|P-value:3.69E-4 ID:SGTC_2411|Compound:st077133|FD-Score:2.93|P-value:2.78E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.51|P-value:1.75E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.40|P-value:2.98E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:3.16|P-value:9.61E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.80|P-value:4.91E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.75|P-value:4.86E-6 ID:SGTC_2692|Compound:st077426|FD-Score:3.24|P-value:6.53E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.35|P-value:3.80E-5 ID:SGTC_2706|Compound:st078239|FD-Score:-2.61|P-value:9.31E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-2.93|P-value:2.33E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-2.61|P-value:9.11E-4 ID:SGTC_3163|Compound:9099914|FD-Score:-2.82|P-value:3.80E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.14|P-value:1.06E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-2.84|P-value:3.52E-4

Top fitness defect scores for YOL160W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1741 st038134 6.27 10.2 µM 6.31E-14 5 1.83E-10
2 SGTC_1209 2323-2347 4.95 50.3 µM 2.48E-9 7 3.69E-7
3 SGTC_1211 1056-0033 4.16 32.3 µM 4.42E-7 7 1.56E-5
4 SGTC_1748 st037455 3.96 53.6 µM 1.48E-6 31 3.75E-5
5 SGTC_2493 resveratrol 3.75 26.1 µM 4.86E-6 11 8.89E-5
6 SGTC_2014 4013930 3.69 200.0 µM 6.66E-6 47 1.12E-4
7 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.67 70.1 µM 7.53E-6 37 1.22E-4
8 SGTC_1270 0831-1170 3.58 17.3 µM 1.23E-5 18 1.75E-4
9 SGTC_882 0843-0131 3.57 351.0 µM 1.26E-5 22 1.77E-4
10 SGTC_2487 5918373 3.51 44.0 µM 1.75E-5 26 2.25E-4
11 SGTC_2490 carminic acid 3.40 95.4 µM 2.98E-5 12 3.32E-4
12 SGTC_987 1497-1013 3.36 404.0 µM 3.74E-5 25 3.92E-4
13 SGTC_2693 st077581 3.35 40.7 µM 3.80E-5 64 3.97E-4
14 SGTC_1200 1643-0193 3.34 18.4 µM 4.03E-5 32 4.14E-4
15 SGTC_2692 st077426 3.24 47.7 µM 6.53E-5 48 5.89E-4
16 SGTC_2491 paeonol 3.16 100.0 µM 9.61E-5 19 7.81E-4
17 SGTC_3313 9133968 3.14 57.0 µM 1.06E-4 27 8.40E-4
18 SGTC_1908 st060353 3.07 56.5 µM 1.49E-4 RPP1 & pyrimidine depletion 86 0.00107
19 SGTC_2411 st077133 2.93 39.9 µM 2.78E-4 RNA pol III & RNase P/MRP 105 0.00170
20 SGTC_2492 derrusnin 2.80 100.0 µM 4.91E-4 35 0.00258

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.229 5.28E-41 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.212 1.80E-35 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.179 1.62E-25 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.176 1.22E-24 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.159 2.87E-20 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.154 3.71E-19 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.146 1.65E-17 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.136 2.84E-15 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.124 5.04E-13 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.123 8.84E-13 YER109C FLO8 hom Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
0.122 1.52E-12 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.121 1.94E-12 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.120 3.60E-12 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.116 1.61E-11 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.115 2.62E-11 YGL166W CUP2 hom Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication