YOL163W_p

Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL163W / YOL163W

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.54|P-value:9.47E-5 ID:SGTC_4|Compound:0960-0234|FD-Score:4.18|P-value:5.19E-6 ID:SGTC_113|Compound:0099-0221|FD-Score:2.99|P-value:8.14E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.40|P-value:1.65E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.41|P-value:6.03E-9 ID:SGTC_389|Compound:tpck|FD-Score:-3.13|P-value:5.45E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.87|P-value:2.22E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:3.24|P-value:3.16E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:-3.36|P-value:2.22E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.68|P-value:5.21E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:3.63|P-value:6.47E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.13|P-value:5.32E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:5.22|P-value:1.99E-8 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.47|P-value:1.46E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-4.62|P-value:6.63E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.04|P-value:1.18E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.94|P-value:9.47E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.19|P-value:3.82E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.02|P-value:7.15E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.79|P-value:2.33E-7 ID:SGTC_1919|Compound:st067113|FD-Score:3.43|P-value:1.52E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.49|P-value:1.32E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.33|P-value:2.19E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.26|P-value:3.28E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.06|P-value:6.19E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.94|P-value:9.90E-8 ID:SGTC_2134|Compound:5324836|FD-Score:-3.21|P-value:4.05E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.27|P-value:2.80E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.59|P-value:8.59E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.22|P-value:3.87E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-3.44|P-value:1.60E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.17|P-value:4.08E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.15|P-value:4.38E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.10|P-value:5.27E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.47|P-value:1.28E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.10|P-value:5.36E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.53|P-value:1.11E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.30|P-value:2.84E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:3.54|P-value:9.47E-5 ID:SGTC_4|Compound:0960-0234|FD-Score:4.18|P-value:5.19E-6 ID:SGTC_113|Compound:0099-0221|FD-Score:2.99|P-value:8.14E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.40|P-value:1.65E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.41|P-value:6.03E-9 ID:SGTC_389|Compound:tpck|FD-Score:-3.13|P-value:5.45E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.87|P-value:2.22E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:3.24|P-value:3.16E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:-3.36|P-value:2.22E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.68|P-value:5.21E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:3.63|P-value:6.47E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.13|P-value:5.32E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:5.22|P-value:1.99E-8 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.47|P-value:1.46E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-4.62|P-value:6.63E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.04|P-value:1.18E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.94|P-value:9.47E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.19|P-value:3.82E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.02|P-value:7.15E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.79|P-value:2.33E-7 ID:SGTC_1919|Compound:st067113|FD-Score:3.43|P-value:1.52E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.49|P-value:1.32E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.33|P-value:2.19E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.26|P-value:3.28E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.06|P-value:6.19E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.94|P-value:9.90E-8 ID:SGTC_2134|Compound:5324836|FD-Score:-3.21|P-value:4.05E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.27|P-value:2.80E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.59|P-value:8.59E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.22|P-value:3.87E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-3.44|P-value:1.60E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.17|P-value:4.08E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.15|P-value:4.38E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.10|P-value:5.27E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.47|P-value:1.28E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.10|P-value:5.36E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.53|P-value:1.11E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.30|P-value:2.84E-4

Top fitness defect scores for YOL163W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_115 0527-0192 5.41 112.0 µM 6.03E-9 21 3.10E-8
2 SGTC_1273 0849-0096 5.22 14.1 µM 1.99E-8 RPP1 & pyrimidine depletion 5 9.15E-8
3 SGTC_2119 5528445 4.94 120.6 µM 9.90E-8 6 3.92E-7
4 SGTC_1913 st060213 4.79 96.1 µM 2.33E-7 13 8.52E-7
5 SGTC_4 0960-0234 4.18 25.7 µM 5.19E-6 Golgi 11 1.43E-5
6 SGTC_394 menadione 3.87 8.3 µM 2.22E-5 superoxide 34 5.33E-5
7 SGTC_863 0466-0191 3.68 129.0 µM 5.21E-5 cell wall 83 1.16E-4
8 SGTC_938 3126-1755 3.63 342.0 µM 6.47E-5 17 1.41E-4
9 SGTC_2 0422-0095 3.54 29.0 µM 9.47E-5 redox potentiating 12 2.00E-4
10 SGTC_2973 9094665 3.47 18.0 µM 1.28E-4 NEO1 45 2.63E-4
11 SGTC_1919 st067113 3.43 52.3 µM 1.52E-4 TSC3-RPN4 46 3.07E-4
12 SGTC_114 0364-0001 3.40 490.3 µM 1.65E-4 72 3.31E-4
13 SGTC_1997 st073024 3.33 93.8 µM 2.19E-4 22 4.28E-4
14 SGTC_2246 7293507 3.27 91.6 µM 2.80E-4 55 5.35E-4
15 SGTC_841 0251-0215 3.24 91.2 µM 3.16E-4 99 5.98E-4
16 SGTC_1379 2144-0755 3.19 36.5 µM 3.82E-4 46 7.09E-4
17 SGTC_2785 7756463 3.17 72.7 µM 4.08E-4 65 7.54E-4
18 SGTC_2807 7945238 3.15 52.0 µM 4.38E-4 75 8.04E-4
19 SGTC_2810 7959871 3.10 45.5 µM 5.27E-4 copper-dependent oxidative stress 83 9.52E-4
20 SGTC_2983 9022671 3.10 13.0 µM 5.36E-4 60S ribosome export 34 9.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.67E-16 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.140 4.72E-16 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.115 2.65E-11 YMR192W GYL1 hom Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress
0.111 1.38E-10 YIL059C_d YIL059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
0.108 2.95E-10 YBL083C_d YBL083C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3
0.093 6.48E-8 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.093 7.10E-8 YLL026W HSP104 hom Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.092 9.38E-8 YKR016W FCJ1 hom Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane
0.088 3.01E-7 YBL032W HEK2 hom RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.088 3.27E-7 YLR343W GAS2 hom 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p
0.085 7.72E-7 YDR472W TRS31 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.085 8.61E-7 YPL119C DBP1 hom Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress
0.082 1.72E-6 YLR043C TRX1 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.082 1.81E-6 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.081 2.60E-6 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan