YOL164W / BDS1

Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL164W / BDS1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.44|P-value:1.87E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.11|P-value:6.09E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:5.57|P-value:1.09E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.32|P-value:3.73E-7 ID:SGTC_252|Compound:miconazole|FD-Score:-3.82|P-value:1.81E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-5.35|P-value:2.88E-7 ID:SGTC_350|Compound:k064-0020|FD-Score:-4.02|P-value:8.59E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:5.01|P-value:1.59E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:7.16|P-value:1.37E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.51|P-value:5.21E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:6.96|P-value:4.72E-11 ID:SGTC_633|Compound:0437-0093|FD-Score:3.97|P-value:1.13E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.61|P-value:4.05E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.85|P-value:1.72E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:6.08|P-value:7.66E-9 ID:SGTC_788|Compound:1182-0090|FD-Score:3.66|P-value:3.32E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.80|P-value:1.91E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-4.14|P-value:5.52E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:3.39|P-value:8.27E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.65|P-value:3.45E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-4.00|P-value:9.44E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.70|P-value:2.93E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.54|P-value:5.10E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.51|P-value:5.61E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.89|P-value:1.48E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.12|P-value:6.43E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.39|P-value:1.36E-9 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.72|P-value:2.51E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.51|P-value:5.12E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.49|P-value:5.84E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.43|P-value:7.20E-4 ID:SGTC_1602|Compound:st001878|FD-Score:-3.57|P-value:4.17E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-4.45|P-value:1.59E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.52|P-value:5.37E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.62|P-value:3.89E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.67|P-value:3.27E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.37|P-value:8.75E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-6.55|P-value:4.96E-10 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.95|P-value:1.22E-4 ID:SGTC_2451|Compound:5856223|FD-Score:5.38|P-value:2.76E-7 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.37|P-value:2.22E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.83|P-value:1.89E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.92|P-value:1.35E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.37|P-value:8.87E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.68|P-value:2.90E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.49|P-value:5.44E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.32|P-value:2.69E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.54|P-value:5.09E-4 ID:SGTC_2784|Compound:7567673|FD-Score:7.62|P-value:6.58E-13 ID:SGTC_2925|Compound:9010536|FD-Score:-3.62|P-value:3.63E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.98|P-value:1.09E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.58|P-value:4.41E-4 ID:SGTC_3193|Compound:9111931|FD-Score:4.78|P-value:4.40E-6 ID:SGTC_3292|Compound:9120825|FD-Score:-3.93|P-value:1.21E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.44|P-value:1.87E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.11|P-value:6.09E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:5.57|P-value:1.09E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.32|P-value:3.73E-7 ID:SGTC_252|Compound:miconazole|FD-Score:-3.82|P-value:1.81E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-5.35|P-value:2.88E-7 ID:SGTC_350|Compound:k064-0020|FD-Score:-4.02|P-value:8.59E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:5.01|P-value:1.59E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:7.16|P-value:1.37E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.51|P-value:5.21E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:6.96|P-value:4.72E-11 ID:SGTC_633|Compound:0437-0093|FD-Score:3.97|P-value:1.13E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.61|P-value:4.05E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.85|P-value:1.72E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:6.08|P-value:7.66E-9 ID:SGTC_788|Compound:1182-0090|FD-Score:3.66|P-value:3.32E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.80|P-value:1.91E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-4.14|P-value:5.52E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:3.39|P-value:8.27E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.65|P-value:3.45E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-4.00|P-value:9.44E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.70|P-value:2.93E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.54|P-value:5.10E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.51|P-value:5.61E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.89|P-value:1.48E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.12|P-value:6.43E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.39|P-value:1.36E-9 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.72|P-value:2.51E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.51|P-value:5.12E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.49|P-value:5.84E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.43|P-value:7.20E-4 ID:SGTC_1602|Compound:st001878|FD-Score:-3.57|P-value:4.17E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-4.45|P-value:1.59E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.52|P-value:5.37E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.62|P-value:3.89E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.67|P-value:3.27E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.37|P-value:8.75E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-6.55|P-value:4.96E-10 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.95|P-value:1.22E-4 ID:SGTC_2451|Compound:5856223|FD-Score:5.38|P-value:2.76E-7 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.37|P-value:2.22E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.83|P-value:1.89E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.92|P-value:1.35E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.37|P-value:8.87E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.68|P-value:2.90E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.49|P-value:5.44E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.32|P-value:2.69E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.54|P-value:5.09E-4 ID:SGTC_2784|Compound:7567673|FD-Score:7.62|P-value:6.58E-13 ID:SGTC_2925|Compound:9010536|FD-Score:-3.62|P-value:3.63E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.98|P-value:1.09E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.58|P-value:4.41E-4 ID:SGTC_3193|Compound:9111931|FD-Score:4.78|P-value:4.40E-6 ID:SGTC_3292|Compound:9120825|FD-Score:-3.93|P-value:1.21E-4

Top fitness defect scores for YOL164W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2784 7567673 7.62 72.7 µM 6.58E-13 iron homeostasis 3 1.25E-14
2 SGTC_367 0335-0881 7.16 7.1 µM 1.37E-11 ubiquinone biosynthesis & proteasome 16 4.08E-13
3 SGTC_568 1193-0097 6.96 7.5 µM 4.72E-11 ERAD & cell cycle 48 1.70E-12
4 SGTC_1230 0170-0365 6.39 3.8 µM 1.36E-9 endomembrane recycling 16 8.14E-11
5 SGTC_768 0384-0033 6.08 77.3 µM 7.66E-9 fatty acid desaturase (OLE1) 37 5.91E-10
6 SGTC_43 0570-0105 5.57 72.5 µM 1.09E-7 ERG2 43 1.24E-8
7 SGTC_2451 5856223 5.38 45.7 µM 2.76E-7 4 3.64E-8
8 SGTC_46 0329-0187a 5.32 2.2 µM 3.73E-7 35 5.13E-8
9 SGTC_360 0957-0399 5.01 1.0 µM 1.59E-6 cell wall 22 2.71E-7
10 SGTC_3193 9111931 4.78 49.5 µM 4.40E-6 8 8.74E-7
11 SGTC_15 0266-0086 4.44 27.1 µM 1.87E-5 endomembrane recycling 47 4.58E-6
12 SGTC_1212 0520-0165 4.12 585.0 µM 6.43E-5 23 1.89E-5
13 SGTC_2952 9073731 3.98 13.8 µM 1.09E-4 tubulin folding & SWR complex 43 3.46E-5
14 SGTC_633 0437-0093 3.97 97.7 µM 1.13E-4 DNA intercalators 11 3.62E-5
15 SGTC_2420 aureobasidin a 3.95 50.0 nM 1.22E-4 48 3.93E-5
16 SGTC_2575 plumbagin 3.92 510.0 nM 1.35E-4 superoxide 44 4.44E-5
17 SGTC_1110 3-hydroxy-3'-methoxyflavone 3.89 1.2 µM 1.48E-4 iron homeostasis 45 4.94E-5
18 SGTC_756 0508-1999 3.85 28.3 µM 1.72E-4 RPP1 & pyrimidine depletion 30 5.83E-5
19 SGTC_2571 chrysanthemic acid 3.83 100.0 µM 1.89E-4 23 6.51E-5
20 SGTC_971 1315-0384 3.70 26.7 µM 2.93E-4 cell wall signaling 30 1.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 1.99E-45 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.220 7.25E-38 YGR060W ERG25 het C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
0.153 4.62E-19 YOL144W NOP8 het Nucleolar protein required for 60S ribosomal subunit biogenesis
0.149 3.36E-18 YDR317W HIM1 hom Protein of unknown function involved in DNA repair
0.147 1.17E-17 YNL077W APJ1 hom Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.141 3.09E-16 YJL086C_d YJL086C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
0.141 3.12E-16 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.139 7.09E-16 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.134 8.18E-15 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.130 4.01E-14 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.124 6.93E-13 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.118 8.52E-12 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.116 2.18E-11 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.113 5.50E-11 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.110 1.60E-10 YOR070C GYP1 hom Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion