HIPHOP chemogenomics database

YOL164W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain

fixedexpanded
Profile for YOL164W-A / YOL164W-A

Click on Significant Values for Screen Details

Top fitness defect scores for YOL164W-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1922	5578187	5.70	25.0 µM	8.33E-11	TRP & mitochondrial translation	6	5.91E-9
2	SGTC_1927	st060202	5.48	13.8 µM	4.24E-10		5	2.17E-8
3	SGTC_1341	1486-1360	5.47	280.0 µM	4.51E-10		4	2.28E-8
4	SGTC_1929	genistein trimethyl ether	5.33	50.5 µM	1.19E-9		4	4.96E-8
5	SGTC_1126	isoteolin	4.87	1.0 µM	2.48E-8		12	5.64E-7
6	SGTC_1741	st038134	4.46	10.2 µM	2.97E-7		20	4.14E-6
7	SGTC_68	0986-0284	4.27	82.8 µM	8.63E-7		53	9.74E-6
8	SGTC_1924	st058459	4.26	75.1 µM	8.98E-7		3	1.01E-5
9	SGTC_1370	2001-0092	4.11	44.6 µM	2.11E-6		25	2.00E-5
10	SGTC_505	gw-5074	3.98	63.9 µM	4.11E-6		56	3.41E-5
11	SGTC_1745	st081495	3.98	74.0 µM	4.13E-6	RNA processing & uracil transport	73	3.43E-5
12	SGTC_786	4544-0069	3.79	423.0 µM	1.13E-5		40	7.69E-5
13	SGTC_1679	4130-1276	3.78	6.7 µM	1.16E-5	Golgi	73	7.88E-5
14	SGTC_564	3555-0129	3.74	330.0 µM	1.38E-5		6	9.02E-5
15	SGTC_591	4299-0174	3.65	154.0 µM	2.24E-5		13	1.34E-4
16	SGTC_2014	4013930	3.57	200.0 µM	3.19E-5		58	1.78E-4
17	SGTC_1635	st007035	3.43	42.4 µM	6.07E-5		254	2.98E-4
18	SGTC_1830	st055982	3.37	50.3 µM	8.03E-5		42	3.74E-4
19	SGTC_236	1509-0011	3.26	5.3 µM	1.32E-4		442	5.59E-4
20	SGTC_1990	st072050	3.13	59.8 µM	2.29E-4		42	8.71E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.172	1.46E-23	YEL059C-A	SOM1	hom	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.162	3.27E-21	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.151	1.60E-18	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.148	9.01E-18	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.146	2.30E-17	YMR151W_d	YIM2_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.145	2.60E-17	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.139	5.53E-16	YGR183C	QCR9	hom	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.138	1.02E-15	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.136	2.78E-15	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.133	1.07E-14	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.129	5.52E-14	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.129	5.57E-14	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.129	7.21E-14	YKL087C	CYT2	hom	Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.128	1.02E-13	YLL009C	COX17	hom	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.128	1.20E-13	YGR174C	CBP4	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex