HIPHOP chemogenomics database

YOR007C / SGT2

Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR007C / SGT2

Click on Significant Values for Screen Details

Top fitness defect scores for YOR007C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_922	1866-0035	6.02	480.0 µM	3.58E-11	excess fatty acid	19	8.62E-10
2	SGTC_1129	3453-1384	5.89	223.0 µM	9.06E-11		12	1.91E-9
3	SGTC_2534	helenine	5.21	20.1 µM	8.84E-9	RSC complex & mRNA processing	8	9.66E-8
4	SGTC_2049	5262831	5.03	67.2 µM	2.63E-8		11	2.46E-7
5	SGTC_1255	0566-0045	4.61	221.0 µM	3.06E-7	excess fatty acid	17	2.02E-6
6	SGTC_660	4031-1742	4.46	102.0 µM	6.88E-7	redox potentiating	32	4.06E-6
7	SGTC_640	3381-0960	4.39	37.1 µM	1.01E-6		5	5.64E-6
8	SGTC_2605	digitonin	4.36	300.0 nM	1.17E-6		18	6.39E-6
9	SGTC_2831	7999036	4.30	19.5 µM	1.65E-6		33	8.59E-6
10	SGTC_2660	2',4'-dihydroxychalcone	4.02	17.1 µM	6.81E-6		16	2.91E-5
11	SGTC_1130	3454-2858	4.00	15.9 µM	7.58E-6	NEO1	89	3.19E-5
12	SGTC_926	2268-1401	3.87	59.4 µM	1.39E-5	TSC3-RPN4	32	5.36E-5
13	SGTC_2510	benzyl isothiocyanate	3.73	8.3 µM	2.73E-5		21	9.58E-5
14	SGTC_650	1328-0195	3.72	38.0 µM	2.84E-5		22	9.93E-5
15	SGTC_2836	9010338	3.62	19.5 µM	4.55E-5	RPP1 & pyrimidine depletion	41	1.49E-4
16	SGTC_2967	9089538	3.62	49.9 µM	4.59E-5		46	1.50E-4
17	SGTC_25	0118-0223	3.43	35.7 µM	1.02E-4		33	2.99E-4
18	SGTC_2976	9009005	3.42	19.5 µM	1.07E-4		45	3.11E-4
19	SGTC_649	1123-0311	3.30	367.0 µM	1.82E-4	endomembrane recycling	112	4.91E-4
20	SGTC_743	1275-0778	3.27	158.0 µM	2.02E-4	excess fatty acid	67	5.39E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.262	5.87E-54	YDR479C	PEX29	hom	Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.165	6.65E-22	YLR324W	PEX30	hom	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.150	2.73E-18	YGL184C	STR3	hom	Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p
0.131	2.65E-14	YBR086C	IST2	hom	Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
0.127	1.76E-13	YDL100C	GET3	hom	Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.126	2.36E-13	YJL035C	TAD2	het	Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
0.120	2.94E-12	YMR182W-A_p	YMR182W-A_p	hom	Putative protein of unknown function
0.117	1.07E-11	YGL132W_d	YGL132W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C
0.109	2.20E-10	YLL001W	DNM1	hom	Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.108	3.20E-10	YOR062C_p	YOR062C_p	hom	Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.103	2.43E-9	YHR110W	ERP5	hom	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.101	5.24E-9	YMR063W	RIM9	hom	Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.101	5.43E-9	YNR008W	LRO1	hom	Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.100	7.63E-9	YDL180W_p	YDL180W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.099	9.62E-9	YDR329C	PEX3	hom	Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p