YOR008C / SLG1

Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR008C / SLG1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:11.00|P-value:3.17E-16 ID:SGTC_70|Compound:0141-0289|FD-Score:7.38|P-value:3.22E-8 ID:SGTC_71|Compound:0417-1750|FD-Score:6.20|P-value:2.71E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:5.04|P-value:1.10E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.31|P-value:7.88E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-4.63|P-value:3.50E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.99|P-value:5.63E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:6.34|P-value:1.66E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:4.42|P-value:5.97E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.18|P-value:7.28E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.69|P-value:2.99E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-5.21|P-value:6.77E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:5.01|P-value:1.18E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:5.12|P-value:8.81E-5 ID:SGTC_465|Compound:cgp-37157|FD-Score:4.45|P-value:5.48E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.84|P-value:1.91E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:6.21|P-value:2.62E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:5.22|P-value:6.56E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:5.51|P-value:2.69E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:10.50|P-value:5.49E-15 ID:SGTC_928|Compound:2764-0428|FD-Score:6.95|P-value:1.72E-7 ID:SGTC_1053|Compound:3366-3204|FD-Score:5.93|P-value:7.01E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-4.85|P-value:1.89E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:5.21|P-value:6.78E-5 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.33|P-value:7.45E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.67|P-value:3.12E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:7.38|P-value:3.19E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.42|P-value:6.00E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-7.40|P-value:2.90E-8 ID:SGTC_1516|Compound:st013856|FD-Score:4.84|P-value:1.92E-4 ID:SGTC_1547|Compound:harmine|FD-Score:8.19|P-value:9.50E-10 ID:SGTC_1581|Compound:himbacine|FD-Score:6.92|P-value:1.97E-7 ID:SGTC_1608|Compound:st001473|FD-Score:5.81|P-value:1.03E-5 ID:SGTC_1614|Compound:st002383|FD-Score:4.59|P-value:3.86E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.13|P-value:8.37E-5 ID:SGTC_1766|Compound:st045414|FD-Score:5.33|P-value:4.69E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.69|P-value:4.73E-7 ID:SGTC_1853|Compound:st056710|FD-Score:-4.32|P-value:7.73E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-4.83|P-value:2.00E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.82|P-value:9.82E-6 ID:SGTC_2007|Compound:4011539|FD-Score:7.63|P-value:1.11E-8 ID:SGTC_2009|Compound:4012297|FD-Score:7.16|P-value:7.76E-8 ID:SGTC_2028|Compound:5153890|FD-Score:6.73|P-value:4.05E-7 ID:SGTC_2149|Compound:5554786|FD-Score:8.71|P-value:8.49E-11 ID:SGTC_2210|Compound:7115885|FD-Score:6.67|P-value:5.11E-7 ID:SGTC_2241|Compound:6772625|FD-Score:5.09|P-value:9.47E-5 ID:SGTC_2289|Compound:7946404|FD-Score:8.49|P-value:2.49E-10 ID:SGTC_2292|Compound:7671323|FD-Score:6.20|P-value:2.74E-6 ID:SGTC_2293|Compound:7624732|FD-Score:7.84|P-value:4.56E-9 ID:SGTC_2302|Compound:7771753|FD-Score:-5.08|P-value:1.00E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.23|P-value:9.66E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.28|P-value:8.50E-4 ID:SGTC_2363|Compound:9053361|FD-Score:5.34|P-value:4.48E-5 ID:SGTC_2399|Compound:5884133|FD-Score:11.80|P-value:2.34E-18 ID:SGTC_2400|Compound:5203494|FD-Score:6.29|P-value:2.03E-6 ID:SGTC_2488|Compound:5268135|FD-Score:4.75|P-value:2.48E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.63|P-value:5.77E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.40|P-value:2.88E-8 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:9.29|P-value:4.92E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.26|P-value:5.70E-12 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.25|P-value:5.91E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-7.35|P-value:3.69E-8 ID:SGTC_2759|Compound:disulfiram|FD-Score:6.48|P-value:1.01E-6 ID:SGTC_2880|Compound:9042983|FD-Score:-5.43|P-value:3.49E-5 ID:SGTC_2912|Compound:7964298|FD-Score:8.40|P-value:3.63E-10 ID:SGTC_2929|Compound:9013348|FD-Score:4.52|P-value:4.54E-4 ID:SGTC_2959|Compound:9079155|FD-Score:4.35|P-value:7.10E-4 ID:SGTC_2960|Compound:9079389|FD-Score:7.74|P-value:7.10E-9 ID:SGTC_3028|Compound:9087778|FD-Score:5.89|P-value:7.97E-6 ID:SGTC_3037|Compound:9091026|FD-Score:-4.72|P-value:2.76E-4 ID:SGTC_3078|Compound:9116413|FD-Score:5.60|P-value:2.02E-5 ID:SGTC_3285|Compound:9112818|FD-Score:7.18|P-value:7.02E-8 ID:SGTC_3296|Compound:9122258|FD-Score:7.32|P-value:4.10E-8 ID:SGTC_3311|Compound:9131146|FD-Score:5.53|P-value:2.50E-5 ID:SGTC_3322|Compound:9139058|FD-Score:5.10|P-value:9.22E-5 ID:SGTC_3350|Compound:9150499|FD-Score:6.34|P-value:1.66E-6 ID:SGTC_3356|Compound:9151811|FD-Score:5.91|P-value:7.38E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:11.00|P-value:3.17E-16 ID:SGTC_70|Compound:0141-0289|FD-Score:7.38|P-value:3.22E-8 ID:SGTC_71|Compound:0417-1750|FD-Score:6.20|P-value:2.71E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:5.04|P-value:1.10E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.31|P-value:7.88E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-4.63|P-value:3.50E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.99|P-value:5.63E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:6.34|P-value:1.66E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:4.42|P-value:5.97E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.18|P-value:7.28E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.69|P-value:2.99E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-5.21|P-value:6.77E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:5.01|P-value:1.18E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:5.12|P-value:8.81E-5 ID:SGTC_465|Compound:cgp-37157|FD-Score:4.45|P-value:5.48E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.84|P-value:1.91E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:6.21|P-value:2.62E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:5.22|P-value:6.56E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:5.51|P-value:2.69E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:10.50|P-value:5.49E-15 ID:SGTC_928|Compound:2764-0428|FD-Score:6.95|P-value:1.72E-7 ID:SGTC_1053|Compound:3366-3204|FD-Score:5.93|P-value:7.01E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-4.85|P-value:1.89E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:5.21|P-value:6.78E-5 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.33|P-value:7.45E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.67|P-value:3.12E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:7.38|P-value:3.19E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.42|P-value:6.00E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-7.40|P-value:2.90E-8 ID:SGTC_1516|Compound:st013856|FD-Score:4.84|P-value:1.92E-4 ID:SGTC_1547|Compound:harmine|FD-Score:8.19|P-value:9.50E-10 ID:SGTC_1581|Compound:himbacine|FD-Score:6.92|P-value:1.97E-7 ID:SGTC_1608|Compound:st001473|FD-Score:5.81|P-value:1.03E-5 ID:SGTC_1614|Compound:st002383|FD-Score:4.59|P-value:3.86E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.13|P-value:8.37E-5 ID:SGTC_1766|Compound:st045414|FD-Score:5.33|P-value:4.69E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.69|P-value:4.73E-7 ID:SGTC_1853|Compound:st056710|FD-Score:-4.32|P-value:7.73E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-4.83|P-value:2.00E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.82|P-value:9.82E-6 ID:SGTC_2007|Compound:4011539|FD-Score:7.63|P-value:1.11E-8 ID:SGTC_2009|Compound:4012297|FD-Score:7.16|P-value:7.76E-8 ID:SGTC_2028|Compound:5153890|FD-Score:6.73|P-value:4.05E-7 ID:SGTC_2149|Compound:5554786|FD-Score:8.71|P-value:8.49E-11 ID:SGTC_2210|Compound:7115885|FD-Score:6.67|P-value:5.11E-7 ID:SGTC_2241|Compound:6772625|FD-Score:5.09|P-value:9.47E-5 ID:SGTC_2289|Compound:7946404|FD-Score:8.49|P-value:2.49E-10 ID:SGTC_2292|Compound:7671323|FD-Score:6.20|P-value:2.74E-6 ID:SGTC_2293|Compound:7624732|FD-Score:7.84|P-value:4.56E-9 ID:SGTC_2302|Compound:7771753|FD-Score:-5.08|P-value:1.00E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.23|P-value:9.66E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.28|P-value:8.50E-4 ID:SGTC_2363|Compound:9053361|FD-Score:5.34|P-value:4.48E-5 ID:SGTC_2399|Compound:5884133|FD-Score:11.80|P-value:2.34E-18 ID:SGTC_2400|Compound:5203494|FD-Score:6.29|P-value:2.03E-6 ID:SGTC_2488|Compound:5268135|FD-Score:4.75|P-value:2.48E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.63|P-value:5.77E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.40|P-value:2.88E-8 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:9.29|P-value:4.92E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.26|P-value:5.70E-12 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.25|P-value:5.91E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-7.35|P-value:3.69E-8 ID:SGTC_2759|Compound:disulfiram|FD-Score:6.48|P-value:1.01E-6 ID:SGTC_2880|Compound:9042983|FD-Score:-5.43|P-value:3.49E-5 ID:SGTC_2912|Compound:7964298|FD-Score:8.40|P-value:3.63E-10 ID:SGTC_2929|Compound:9013348|FD-Score:4.52|P-value:4.54E-4 ID:SGTC_2959|Compound:9079155|FD-Score:4.35|P-value:7.10E-4 ID:SGTC_2960|Compound:9079389|FD-Score:7.74|P-value:7.10E-9 ID:SGTC_3028|Compound:9087778|FD-Score:5.89|P-value:7.97E-6 ID:SGTC_3037|Compound:9091026|FD-Score:-4.72|P-value:2.76E-4 ID:SGTC_3078|Compound:9116413|FD-Score:5.60|P-value:2.02E-5 ID:SGTC_3285|Compound:9112818|FD-Score:7.18|P-value:7.02E-8 ID:SGTC_3296|Compound:9122258|FD-Score:7.32|P-value:4.10E-8 ID:SGTC_3311|Compound:9131146|FD-Score:5.53|P-value:2.50E-5 ID:SGTC_3322|Compound:9139058|FD-Score:5.10|P-value:9.22E-5 ID:SGTC_3350|Compound:9150499|FD-Score:6.34|P-value:1.66E-6 ID:SGTC_3356|Compound:9151811|FD-Score:5.91|P-value:7.38E-6

Top fitness defect scores for YOR008C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2399 5884133 11.80 200.0 µM 2.34E-18 cell wall signaling 10 1.60E-32
2 SGTC_58 0957-0393 11.00 9.0 µM 3.17E-16 cell wall 65 1.41E-28
3 SGTC_666 0272-0154 10.50 136.0 µM 5.49E-15 cell wall 5 2.74E-26
4 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 9.29 70.0 µM 4.92E-12 redox potentiating 11 7.77E-21
5 SGTC_2679 rapamycin 9.26 1.0 nM 5.70E-12 32 1.02E-20
6 SGTC_2149 5554786 8.71 194.8 µM 8.49E-11 cell wall signaling 4 1.48E-18
7 SGTC_2289 7946404 8.49 165.1 µM 2.49E-10 12 1.07E-17
8 SGTC_2912 7964298 8.40 10.9 µM 3.63E-10 cell wall 24 2.15E-17
9 SGTC_1547 harmine 8.19 94.2 µM 9.50E-10 ergosterol biosynthesis 10 1.26E-16
10 SGTC_2293 7624732 7.84 200.0 µM 4.56E-9 1 2.26E-15
11 SGTC_2960 9079389 7.74 6.0 µM 7.10E-9 2 5.11E-15
12 SGTC_2007 4011539 7.63 71.8 µM 1.11E-8 cell wall signaling 17 1.15E-14
13 SGTC_2582 agaric acid 7.40 100.0 µM 2.88E-8 redox potentiating 116 6.71E-14
14 SGTC_1124 fisetin 7.38 1.2 µM 3.19E-8 2 8.06E-14
15 SGTC_70 0141-0289 7.38 43.3 µM 3.22E-8 mitochondrial stress 47 8.19E-14
16 SGTC_3296 9122258 7.32 64.0 µM 4.10E-8 redox potentiating 3 1.28E-13
17 SGTC_3285 9112818 7.18 20.9 µM 7.02E-8 cell wall 5 3.44E-13
18 SGTC_2009 4012297 7.16 12.1 µM 7.76E-8 cell wall signaling 18 4.12E-13
19 SGTC_928 2764-0428 6.95 58.7 µM 1.72E-7 cell wall 9 1.77E-12
20 SGTC_1581 himbacine 6.92 57.9 µM 1.97E-7 Golgi 15 2.27E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.372 1.30E-110 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.352 2.46E-98 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.345 1.77E-94 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.328 5.59E-85 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.307 3.62E-74 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.281 5.75E-62 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.274 1.17E-58 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.269 4.04E-56 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.266 2.89E-55 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.263 2.43E-54 YLR371W ROM2 hom GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p
0.242 9.45E-46 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.210 9.03E-35 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.209 1.70E-34 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.206 2.57E-33 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.199 2.21E-31 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly