YOR008C-A_p

Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR008C-A / YOR008C-A

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:-4.50|P-value:5.05E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.00|P-value:5.53E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.03|P-value:6.07E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.53|P-value:6.94E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.18|P-value:3.00E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.40|P-value:1.18E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.62|P-value:4.68E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.91|P-value:1.07E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.82|P-value:5.38E-22 ID:SGTC_669|Compound:0108-0021|FD-Score:3.42|P-value:1.13E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:2.94|P-value:7.53E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.82|P-value:1.80E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:4.00|P-value:7.83E-6 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.02|P-value:5.22E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.01|P-value:5.36E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.05|P-value:4.87E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.76|P-value:2.40E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-6.14|P-value:1.39E-11 ID:SGTC_1193|Compound:1488-0126|FD-Score:-2.99|P-value:5.77E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.36|P-value:1.31E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.70|P-value:3.14E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.99|P-value:8.08E-6 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.63|P-value:4.42E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.27|P-value:2.07E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.37|P-value:1.25E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.55|P-value:6.28E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.89|P-value:8.37E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.50|P-value:7.70E-5 ID:SGTC_1638|Compound:st008370|FD-Score:-2.88|P-value:8.59E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.37|P-value:1.19E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-2.95|P-value:6.75E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.52|P-value:7.14E-5 ID:SGTC_2016|Compound:5121758|FD-Score:7.06|P-value:1.13E-14 ID:SGTC_2050|Compound:5263056|FD-Score:3.40|P-value:1.18E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.04|P-value:4.85E-4 ID:SGTC_2438|Compound:5259590|FD-Score:2.87|P-value:9.80E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.51|P-value:7.43E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.12|P-value:3.44E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.47|P-value:8.13E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.66|P-value:4.64E-10 ID:SGTC_2817|Compound:7995342|FD-Score:-3.82|P-value:1.66E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.13|P-value:3.33E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-2.92|P-value:7.63E-4 ID:SGTC_2848|Compound:9016370|FD-Score:2.97|P-value:6.64E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.16|P-value:3.01E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.09|P-value:3.97E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.18|P-value:2.92E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.26|P-value:2.12E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.07|P-value:4.17E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.13|P-value:3.69E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.22|P-value:2.33E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:-4.50|P-value:5.05E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.00|P-value:5.53E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.03|P-value:6.07E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.53|P-value:6.94E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.18|P-value:3.00E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.40|P-value:1.18E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.62|P-value:4.68E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.91|P-value:1.07E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.82|P-value:5.38E-22 ID:SGTC_669|Compound:0108-0021|FD-Score:3.42|P-value:1.13E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:2.94|P-value:7.53E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.82|P-value:1.80E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:4.00|P-value:7.83E-6 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.02|P-value:5.22E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.01|P-value:5.36E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.05|P-value:4.87E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.76|P-value:2.40E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-6.14|P-value:1.39E-11 ID:SGTC_1193|Compound:1488-0126|FD-Score:-2.99|P-value:5.77E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.36|P-value:1.31E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.70|P-value:3.14E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.99|P-value:8.08E-6 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.63|P-value:4.42E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.27|P-value:2.07E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.37|P-value:1.25E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.55|P-value:6.28E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.89|P-value:8.37E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.50|P-value:7.70E-5 ID:SGTC_1638|Compound:st008370|FD-Score:-2.88|P-value:8.59E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.37|P-value:1.19E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-2.95|P-value:6.75E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.52|P-value:7.14E-5 ID:SGTC_2016|Compound:5121758|FD-Score:7.06|P-value:1.13E-14 ID:SGTC_2050|Compound:5263056|FD-Score:3.40|P-value:1.18E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.04|P-value:4.85E-4 ID:SGTC_2438|Compound:5259590|FD-Score:2.87|P-value:9.80E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.51|P-value:7.43E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.12|P-value:3.44E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.47|P-value:8.13E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.66|P-value:4.64E-10 ID:SGTC_2817|Compound:7995342|FD-Score:-3.82|P-value:1.66E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.13|P-value:3.33E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-2.92|P-value:7.63E-4 ID:SGTC_2848|Compound:9016370|FD-Score:2.97|P-value:6.64E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.16|P-value:3.01E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.09|P-value:3.97E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.18|P-value:2.92E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.26|P-value:2.12E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.07|P-value:4.17E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.13|P-value:3.69E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.22|P-value:2.33E-4

Top fitness defect scores for YOR008C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2016 5121758 7.06 140.0 µM 1.13E-14 redox potentiating 11 8.43E-13
2 SGTC_2688 kanamycin b 5.66 96.7 µM 4.64E-10 calcium & mitochondrial duress 185 7.54E-9
3 SGTC_1779 st039427 4.37 55.0 µM 1.19E-6 15 6.34E-6
4 SGTC_818 4072-2707 4.00 53.5 µM 7.83E-6 14 3.20E-5
5 SGTC_1211 1056-0033 3.99 32.3 µM 8.08E-6 8 3.29E-5
6 SGTC_778 3456-2434 3.82 196.0 µM 1.80E-5 mitochondrial response to ROS 82 6.55E-5
7 SGTC_1072 oxiconazole 3.76 14.9 nM 2.40E-5 ergosterol depletion effects on membrane 58 8.40E-5
8 SGTC_1210 3013-0140 3.70 750.0 nM 3.14E-5 7 1.06E-4
9 SGTC_1215 3852-0577 3.63 11.2 µM 4.42E-5 24 1.42E-4
10 SGTC_218 alverine citrate 3.62 93.8 µM 4.68E-5 fatty acid desaturase (OLE1) 37 1.49E-4
11 SGTC_1348 1493-0373 3.55 93.8 µM 6.28E-5 23 1.92E-4
12 SGTC_188 3229-0966 3.53 278.5 µM 6.94E-5 39 2.10E-4
13 SGTC_1976 st070609 3.52 63.5 µM 7.14E-5 21 2.15E-4
14 SGTC_2478 5763493 3.51 32.3 µM 7.43E-5 35 2.22E-4
15 SGTC_1520 flindersine 3.50 88.0 µM 7.70E-5 43 2.30E-4
16 SGTC_669 0108-0021 3.42 26.2 µM 1.13E-4 fatty acid desaturase (OLE1) 119 3.19E-4
17 SGTC_215 1287-0124 3.40 461.5 µM 1.18E-4 6 3.32E-4
18 SGTC_2050 5263056 3.40 171.0 µM 1.18E-4 fatty acid desaturase (OLE1) 74 3.32E-4
19 SGTC_1218 1348-1416 3.27 30.7 µM 2.07E-4 SWF1 & branched chain AA biosynthesis 42 5.39E-4
20 SGTC_3152 9099253 3.26 49.5 µM 2.12E-4 NEO1-PIK1 179 5.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 7.88E-35 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.187 1.31E-27 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.184 7.22E-27 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.174 3.67E-24 YGR086C PIL1 hom Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.170 5.07E-23 YDR125C ECM18 hom Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication
0.164 1.17E-21 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.161 5.33E-21 YOR070C GYP1 hom Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
0.159 1.74E-20 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.155 1.81E-19 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.151 1.55E-18 YDR156W RPA14 hom RNA polymerase I subunit A14
0.150 1.98E-18 YNL293W MSB3 hom Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.147 1.29E-17 YOR216C RUD3 hom Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1
0.139 5.48E-16 YEL050C RML2 hom Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
0.138 9.10E-16 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.138 1.18E-15 YDR095C_d YDR095C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data