YOR011W / AUS1

Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR011W / AUS1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.66|P-value:2.48E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.57|P-value:3.38E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:6.41|P-value:5.05E-10 ID:SGTC_297|Compound:0986-0032|FD-Score:3.49|P-value:4.57E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.79|P-value:1.57E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.26|P-value:8.90E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.41|P-value:5.36E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:7.49|P-value:4.81E-13 ID:SGTC_843|Compound:0310-0051|FD-Score:3.29|P-value:8.91E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.70|P-value:2.13E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.65|P-value:2.62E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.83|P-value:1.34E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.82|P-value:1.38E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.23|P-value:2.84E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.70|P-value:2.19E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.64|P-value:2.66E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:-4.02|P-value:6.02E-5 ID:SGTC_1650|Compound:st011916|FD-Score:4.08|P-value:5.24E-5 ID:SGTC_1759|Compound:st043059|FD-Score:5.63|P-value:4.22E-8 ID:SGTC_1764|Compound:st044502|FD-Score:5.22|P-value:3.37E-7 ID:SGTC_2009|Compound:4012297|FD-Score:3.88|P-value:1.11E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-4.77|P-value:2.52E-6 ID:SGTC_2022|Compound:5136654|FD-Score:-4.06|P-value:5.17E-5 ID:SGTC_2041|Compound:5107442|FD-Score:4.90|P-value:1.51E-6 ID:SGTC_2134|Compound:5324836|FD-Score:-3.61|P-value:2.68E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.86|P-value:1.09E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.92|P-value:9.71E-5 ID:SGTC_2434|Compound:5670830|FD-Score:3.47|P-value:4.80E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.76|P-value:1.76E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.68|P-value:2.30E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.48|P-value:4.61E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.33|P-value:7.75E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.94|P-value:8.96E-5 ID:SGTC_2877|Compound:9040724|FD-Score:4.11|P-value:4.65E-5 ID:SGTC_2878|Compound:9043973|FD-Score:4.31|P-value:2.09E-5 ID:SGTC_3150|Compound:9097574|FD-Score:3.47|P-value:4.79E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.64|P-value:2.46E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.63|P-value:2.80E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.90|P-value:1.02E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.63|P-value:2.74E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.66|P-value:2.48E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.57|P-value:3.38E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:6.41|P-value:5.05E-10 ID:SGTC_297|Compound:0986-0032|FD-Score:3.49|P-value:4.57E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.79|P-value:1.57E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.26|P-value:8.90E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.41|P-value:5.36E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:7.49|P-value:4.81E-13 ID:SGTC_843|Compound:0310-0051|FD-Score:3.29|P-value:8.91E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.70|P-value:2.13E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.65|P-value:2.62E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.83|P-value:1.34E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.82|P-value:1.38E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.23|P-value:2.84E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.70|P-value:2.19E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.64|P-value:2.66E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:-4.02|P-value:6.02E-5 ID:SGTC_1650|Compound:st011916|FD-Score:4.08|P-value:5.24E-5 ID:SGTC_1759|Compound:st043059|FD-Score:5.63|P-value:4.22E-8 ID:SGTC_1764|Compound:st044502|FD-Score:5.22|P-value:3.37E-7 ID:SGTC_2009|Compound:4012297|FD-Score:3.88|P-value:1.11E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-4.77|P-value:2.52E-6 ID:SGTC_2022|Compound:5136654|FD-Score:-4.06|P-value:5.17E-5 ID:SGTC_2041|Compound:5107442|FD-Score:4.90|P-value:1.51E-6 ID:SGTC_2134|Compound:5324836|FD-Score:-3.61|P-value:2.68E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.86|P-value:1.09E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.92|P-value:9.71E-5 ID:SGTC_2434|Compound:5670830|FD-Score:3.47|P-value:4.80E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.76|P-value:1.76E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.68|P-value:2.30E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.48|P-value:4.61E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.33|P-value:7.75E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.94|P-value:8.96E-5 ID:SGTC_2877|Compound:9040724|FD-Score:4.11|P-value:4.65E-5 ID:SGTC_2878|Compound:9043973|FD-Score:4.31|P-value:2.09E-5 ID:SGTC_3150|Compound:9097574|FD-Score:3.47|P-value:4.79E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.64|P-value:2.46E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.63|P-value:2.80E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.90|P-value:1.02E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.63|P-value:2.74E-4

Top fitness defect scores for YOR011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_722 3534-0461 7.49 190.0 µM 4.81E-13 PDR1 3 3.47E-14
2 SGTC_196 k015-0023 6.41 18.1 µM 5.05E-10 PDR1 3 7.19E-11
3 SGTC_1759 st043059 5.63 70.0 µM 4.22E-8 amide catabolism 6 9.24E-9
4 SGTC_1764 st044502 5.22 93.5 µM 3.37E-7 14 9.03E-8
5 SGTC_2041 5107442 4.90 45.3 µM 1.51E-6 RSC complex & mRNA processing 12 4.68E-7
6 SGTC_2878 9043973 4.31 26.0 µM 2.09E-5 13 8.34E-6
7 SGTC_1204 4049-0315 4.23 18.3 µM 2.84E-5 20 1.17E-5
8 SGTC_2877 9040724 4.11 71.4 µM 4.65E-5 5 2.00E-5
9 SGTC_1650 st011916 4.08 45.8 µM 5.24E-5 11 2.28E-5
10 SGTC_2832 7992762 3.94 52.0 µM 8.96E-5 32 4.11E-5
11 SGTC_2329 6138490 3.92 200.0 µM 9.71E-5 31 4.49E-5
12 SGTC_3271 9137798 3.90 49.5 µM 1.02E-4 5 4.76E-5
13 SGTC_2009 4012297 3.88 12.1 µM 1.11E-4 cell wall signaling 62 5.22E-5
14 SGTC_1043 0916-0009 3.83 19.3 µM 1.34E-4 26 6.36E-5
15 SGTC_1201 1889-3372 3.82 45.9 µM 1.38E-4 Golgi 11 6.60E-5
16 SGTC_403 arphamenine a 3.79 50.0 µM 1.57E-4 60S ribosome export 19 7.58E-5
17 SGTC_2638 epoxomicin 3.76 18.0 µM 1.76E-4 41 8.61E-5
18 SGTC_1013 4112-3890 3.70 241.0 µM 2.13E-4 TSC3-RPN4 40 1.06E-4
19 SGTC_1206 3978-0017 3.70 132.0 µM 2.19E-4 ERG2 46 1.09E-4
20 SGTC_2666 tannic acid 3.68 100.0 µM 2.30E-4 iron homeostasis 48 1.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.10E-14 YHR103W SBE22 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.110 1.65E-10 YHR113W APE4 hom Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family
0.105 9.89E-10 YNR046W TRM112 het Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress
0.100 6.84E-9 YNL193W_p YNL193W_p hom Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
0.100 6.95E-9 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.090 2.25E-7 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.089 2.08E-7 YCR034W FEN1 hom Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication
0.085 9.35E-7 YCL057W PRD1 hom Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress
0.081 2.74E-6 YOR337W TEA1 hom Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein
0.080 3.14E-6 YOR293C-A_p YOR293C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.080 3.31E-6 YHR189W PTH1 hom One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium
0.079 4.21E-6 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.079 5.25E-6 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.077 7.34E-6 YKL041W VPS24 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
0.075 1.27E-5 YHR061C GIC1 hom Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress