YOR014W / RTS1

B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR014W / RTS1

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:4.55|P-value:4.53E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-12.50|P-value:6.29E-27 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.94|P-value:3.45E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-5.77|P-value:4.34E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:-7.58|P-value:5.08E-11 ID:SGTC_184|Compound:1494-0393|FD-Score:7.16|P-value:3.95E-10 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.03|P-value:2.60E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:8.23|P-value:8.35E-13 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.49|P-value:6.52E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.76|P-value:6.86E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:4.47|P-value:6.00E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:4.77|P-value:2.04E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:4.24|P-value:1.34E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:5.96|P-value:1.55E-7 ID:SGTC_756|Compound:0508-1999|FD-Score:6.66|P-value:5.46E-9 ID:SGTC_758|Compound:0868-0029|FD-Score:-9.76|P-value:3.99E-17 ID:SGTC_819|Compound:1013-0258|FD-Score:3.71|P-value:7.04E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:8.17|P-value:1.17E-12 ID:SGTC_937|Compound:3122-0005|FD-Score:5.53|P-value:1.02E-6 ID:SGTC_1011|Compound:4112-3381|FD-Score:5.01|P-value:8.41E-6 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.09|P-value:2.20E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.60|P-value:9.67E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.66|P-value:3.02E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.84|P-value:4.72E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:4.29|P-value:1.11E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.34|P-value:9.61E-5 ID:SGTC_1558|Compound:st069300|FD-Score:5.47|P-value:1.32E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-5.34|P-value:2.72E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.77|P-value:5.92E-4 ID:SGTC_1602|Compound:st001878|FD-Score:8.15|P-value:1.32E-12 ID:SGTC_1644|Compound:st010134|FD-Score:3.64|P-value:8.73E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.83|P-value:4.87E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.79|P-value:5.54E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.83|P-value:4.82E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.20|P-value:1.50E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.86|P-value:4.49E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.73|P-value:6.63E-4 ID:SGTC_1991|Compound:st073000|FD-Score:5.15|P-value:4.80E-6 ID:SGTC_2040|Compound:5100729|FD-Score:4.18|P-value:1.59E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.97|P-value:9.51E-6 ID:SGTC_2081|Compound:5214970|FD-Score:4.30|P-value:1.09E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:7.86|P-value:7.78E-12 ID:SGTC_2133|Compound:5320837|FD-Score:-4.65|P-value:3.78E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-4.06|P-value:2.77E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.75|P-value:6.30E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.82|P-value:5.03E-4 ID:SGTC_2411|Compound:st077133|FD-Score:5.81|P-value:3.04E-7 ID:SGTC_2416|Compound:tofa|FD-Score:5.77|P-value:3.61E-7 ID:SGTC_2457|Compound:5731572|FD-Score:4.45|P-value:6.41E-5 ID:SGTC_2463|Compound:5473429|FD-Score:4.65|P-value:3.16E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.63|P-value:8.97E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.15|P-value:1.78E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.66|P-value:3.12E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.98|P-value:3.04E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.84|P-value:4.81E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:8.70|P-value:4.30E-14 ID:SGTC_2867|Compound:9039098|FD-Score:4.14|P-value:1.87E-4 ID:SGTC_2878|Compound:9043973|FD-Score:5.56|P-value:8.85E-7 ID:SGTC_2889|Compound:9059656|FD-Score:4.32|P-value:1.03E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.28|P-value:1.15E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.74|P-value:6.40E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.22|P-value:1.43E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.91|P-value:3.84E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.90|P-value:3.93E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.14|P-value:1.83E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.65|P-value:8.43E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:4.55|P-value:4.53E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-12.50|P-value:6.29E-27 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.94|P-value:3.45E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-5.77|P-value:4.34E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:-7.58|P-value:5.08E-11 ID:SGTC_184|Compound:1494-0393|FD-Score:7.16|P-value:3.95E-10 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.03|P-value:2.60E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:8.23|P-value:8.35E-13 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.49|P-value:6.52E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.76|P-value:6.86E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:4.47|P-value:6.00E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:4.77|P-value:2.04E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:4.24|P-value:1.34E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:5.96|P-value:1.55E-7 ID:SGTC_756|Compound:0508-1999|FD-Score:6.66|P-value:5.46E-9 ID:SGTC_758|Compound:0868-0029|FD-Score:-9.76|P-value:3.99E-17 ID:SGTC_819|Compound:1013-0258|FD-Score:3.71|P-value:7.04E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:8.17|P-value:1.17E-12 ID:SGTC_937|Compound:3122-0005|FD-Score:5.53|P-value:1.02E-6 ID:SGTC_1011|Compound:4112-3381|FD-Score:5.01|P-value:8.41E-6 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.09|P-value:2.20E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.60|P-value:9.67E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.66|P-value:3.02E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.84|P-value:4.72E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:4.29|P-value:1.11E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.34|P-value:9.61E-5 ID:SGTC_1558|Compound:st069300|FD-Score:5.47|P-value:1.32E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-5.34|P-value:2.72E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.77|P-value:5.92E-4 ID:SGTC_1602|Compound:st001878|FD-Score:8.15|P-value:1.32E-12 ID:SGTC_1644|Compound:st010134|FD-Score:3.64|P-value:8.73E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.83|P-value:4.87E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.79|P-value:5.54E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.83|P-value:4.82E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.20|P-value:1.50E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.86|P-value:4.49E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.73|P-value:6.63E-4 ID:SGTC_1991|Compound:st073000|FD-Score:5.15|P-value:4.80E-6 ID:SGTC_2040|Compound:5100729|FD-Score:4.18|P-value:1.59E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.97|P-value:9.51E-6 ID:SGTC_2081|Compound:5214970|FD-Score:4.30|P-value:1.09E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:7.86|P-value:7.78E-12 ID:SGTC_2133|Compound:5320837|FD-Score:-4.65|P-value:3.78E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-4.06|P-value:2.77E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.75|P-value:6.30E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.82|P-value:5.03E-4 ID:SGTC_2411|Compound:st077133|FD-Score:5.81|P-value:3.04E-7 ID:SGTC_2416|Compound:tofa|FD-Score:5.77|P-value:3.61E-7 ID:SGTC_2457|Compound:5731572|FD-Score:4.45|P-value:6.41E-5 ID:SGTC_2463|Compound:5473429|FD-Score:4.65|P-value:3.16E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.63|P-value:8.97E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.15|P-value:1.78E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.66|P-value:3.12E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.98|P-value:3.04E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.84|P-value:4.81E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:8.70|P-value:4.30E-14 ID:SGTC_2867|Compound:9039098|FD-Score:4.14|P-value:1.87E-4 ID:SGTC_2878|Compound:9043973|FD-Score:5.56|P-value:8.85E-7 ID:SGTC_2889|Compound:9059656|FD-Score:4.32|P-value:1.03E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.28|P-value:1.15E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.74|P-value:6.40E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.22|P-value:1.43E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.91|P-value:3.84E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.90|P-value:3.93E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.14|P-value:1.83E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.65|P-value:8.43E-4

Top fitness defect scores for YOR014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2771 fluoxetine 8.70 41.0 µM 4.30E-14 1 1.72E-18
2 SGTC_268 camptothecin 8.23 39.6 µM 8.35E-13 DNA damage response 13 9.57E-17
3 SGTC_934 2950-0684 8.17 338.0 µM 1.17E-12 3 1.52E-16
4 SGTC_1602 st001878 8.15 87.6 µM 1.32E-12 1 1.78E-16
5 SGTC_2129 girgensonine 7.86 121.0 µM 7.78E-12 heme biosynthesis & mitochondrial translocase 6 1.97E-15
6 SGTC_184 1494-0393 7.16 24.7 µM 3.95E-10 12 4.00E-13
7 SGTC_756 0508-1999 6.66 28.3 µM 5.46E-9 RPP1 & pyrimidine depletion 1 1.40E-11
8 SGTC_648 0375-0473 5.96 33.3 µM 1.55E-7 1 1.28E-9
9 SGTC_2411 st077133 5.81 39.9 µM 3.04E-7 RNA pol III & RNase P/MRP 7 3.17E-9
10 SGTC_2416 tofa 5.77 880.0 nM 3.61E-7 sphingolipid biosynthesis & PDR1 21 4.00E-9
11 SGTC_2878 9043973 5.56 26.0 µM 8.85E-7 2 1.34E-8
12 SGTC_937 3122-0005 5.53 46.7 µM 1.02E-6 8 1.62E-8
13 SGTC_1558 st069300 5.47 45.6 µM 1.32E-6 4 2.31E-8
14 SGTC_1991 st073000 5.15 8.9 µM 4.80E-6 NEO1 49 1.30E-7
15 SGTC_1011 4112-3381 5.01 17.4 µM 8.41E-6 18 2.77E-7
16 SGTC_2054 5233173 4.97 129.0 µM 9.51E-6 mitochondrial response to ROS 28 3.27E-7
17 SGTC_599 1935-0052 4.77 86.5 µM 2.04E-5 5 9.11E-7
18 SGTC_1167 k781-0610 4.66 148.0 µM 3.02E-5 RNA processing & uracil transport 13 1.54E-6
19 SGTC_2634 4'-methoxyflavone 4.66 100.0 µM 3.12E-5 19 1.61E-6
20 SGTC_2463 5473429 4.65 200.0 µM 3.16E-5 ERG2 8 1.64E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.225 7.36E-40 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.219 1.11E-37 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.210 7.06E-35 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.188 5.37E-28 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.179 1.37E-25 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.171 1.51E-23 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.171 2.17E-23 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.170 3.69E-23 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.163 1.83E-21 YOR033C EXO1 hom 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress
0.158 2.67E-20 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.148 6.25E-18 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.147 1.18E-17 YJR018W_d YJR018W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.146 2.10E-17 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.141 2.52E-16 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.134 5.67E-15 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis