YOR015W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR015W / YOR015W

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:6.23|P-value:3.11E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:4.71|P-value:3.95E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:3.29|P-value:2.82E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.25|P-value:3.29E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-3.02|P-value:7.83E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.60|P-value:6.83E-7 ID:SGTC_427|Compound:1354-0053|FD-Score:3.80|P-value:3.31E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:9.54|P-value:7.19E-24 ID:SGTC_522|Compound:1273-0010|FD-Score:4.02|P-value:1.21E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.01|P-value:7.95E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.25|P-value:3.26E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.65|P-value:6.47E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.16|P-value:4.62E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.28|P-value:2.87E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.31|P-value:3.02E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.59|P-value:8.32E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.28|P-value:2.91E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.26|P-value:3.93E-6 ID:SGTC_1424|Compound:4048-1941|FD-Score:2.94|P-value:9.99E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:4.00|P-value:1.36E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.11|P-value:5.59E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-4.00|P-value:1.38E-5 ID:SGTC_1622|Compound:st003707|FD-Score:3.33|P-value:2.34E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.35|P-value:2.26E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.43|P-value:1.64E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.85|P-value:2.70E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.27|P-value:3.05E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.43|P-value:1.60E-4 ID:SGTC_1897|Compound:st060201|FD-Score:4.28|P-value:3.57E-6 ID:SGTC_1906|Compound:st060206|FD-Score:-3.17|P-value:4.39E-4 ID:SGTC_1907|Compound:st060210|FD-Score:4.21|P-value:5.00E-6 ID:SGTC_1922|Compound:5578187|FD-Score:-3.02|P-value:7.73E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.62|P-value:6.25E-7 ID:SGTC_1990|Compound:st072050|FD-Score:3.25|P-value:3.28E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.09|P-value:5.83E-4 ID:SGTC_2221|Compound:6807166|FD-Score:3.31|P-value:2.58E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.36|P-value:2.14E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.42|P-value:1.65E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.13|P-value:7.15E-6 ID:SGTC_2624|Compound:nerol|FD-Score:-3.23|P-value:3.48E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:4.23|P-value:4.51E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.00|P-value:8.32E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.15|P-value:4.86E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.25|P-value:4.18E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.08|P-value:6.17E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.15|P-value:4.74E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.07|P-value:6.36E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.04|P-value:7.09E-4 ID:SGTC_3291|Compound:9121177|FD-Score:4.93|P-value:1.18E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:6.23|P-value:3.11E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:4.71|P-value:3.95E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:3.29|P-value:2.82E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.25|P-value:3.29E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-3.02|P-value:7.83E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.60|P-value:6.83E-7 ID:SGTC_427|Compound:1354-0053|FD-Score:3.80|P-value:3.31E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:9.54|P-value:7.19E-24 ID:SGTC_522|Compound:1273-0010|FD-Score:4.02|P-value:1.21E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.01|P-value:7.95E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.25|P-value:3.26E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.65|P-value:6.47E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.16|P-value:4.62E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.28|P-value:2.87E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.31|P-value:3.02E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.59|P-value:8.32E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.28|P-value:2.91E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.26|P-value:3.93E-6 ID:SGTC_1424|Compound:4048-1941|FD-Score:2.94|P-value:9.99E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:4.00|P-value:1.36E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.11|P-value:5.59E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-4.00|P-value:1.38E-5 ID:SGTC_1622|Compound:st003707|FD-Score:3.33|P-value:2.34E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.35|P-value:2.26E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.43|P-value:1.64E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.85|P-value:2.70E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.27|P-value:3.05E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.43|P-value:1.60E-4 ID:SGTC_1897|Compound:st060201|FD-Score:4.28|P-value:3.57E-6 ID:SGTC_1906|Compound:st060206|FD-Score:-3.17|P-value:4.39E-4 ID:SGTC_1907|Compound:st060210|FD-Score:4.21|P-value:5.00E-6 ID:SGTC_1922|Compound:5578187|FD-Score:-3.02|P-value:7.73E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.62|P-value:6.25E-7 ID:SGTC_1990|Compound:st072050|FD-Score:3.25|P-value:3.28E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.09|P-value:5.83E-4 ID:SGTC_2221|Compound:6807166|FD-Score:3.31|P-value:2.58E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.36|P-value:2.14E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.42|P-value:1.65E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.13|P-value:7.15E-6 ID:SGTC_2624|Compound:nerol|FD-Score:-3.23|P-value:3.48E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:4.23|P-value:4.51E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.00|P-value:8.32E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.15|P-value:4.86E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.25|P-value:4.18E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.08|P-value:6.17E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.15|P-value:4.74E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.07|P-value:6.36E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.04|P-value:7.09E-4 ID:SGTC_3291|Compound:9121177|FD-Score:4.93|P-value:1.18E-7

Top fitness defect scores for YOR015W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 9.54 2.6 nM 7.19E-24 cell wall 24 7.35E-22
2 SGTC_65 0798-0905 6.23 35.0 µM 3.11E-11 calcium & mitochondrial duress 27 2.31E-10
3 SGTC_3291 9121177 4.93 71.4 µM 1.18E-7 4 4.19E-7
4 SGTC_67 0335-0847 4.71 266.0 µM 3.95E-7 ubiquinone biosynthesis & proteasome 90 1.27E-6
5 SGTC_1931 st074438 4.62 57.1 µM 6.25E-7 7 1.93E-6
6 SGTC_358 0075-0058 4.60 9.4 µM 6.83E-7 39 2.09E-6
7 SGTC_1800 st050079 4.43 29.1 µM 1.64E-6 NEO1-PIK1 99 4.65E-6
8 SGTC_1250 0485-0349 4.31 40.2 µM 3.02E-6 24 8.09E-6
9 SGTC_1897 st060201 4.28 15.0 µM 3.57E-6 mitochondrial processes 13 9.44E-6
10 SGTC_1380 2291-0730 4.26 164.0 µM 3.93E-6 17 1.03E-5
11 SGTC_2857 9024691 4.25 58.4 µM 4.18E-6 17 1.09E-5
12 SGTC_2686 alizarin 4.23 95.4 µM 4.51E-6 RPP1 & pyrimidine depletion 26 1.17E-5
13 SGTC_1907 st060210 4.21 83.7 µM 5.00E-6 14 1.28E-5
14 SGTC_2488 5268135 4.13 45.7 µM 7.15E-6 47 1.78E-5
15 SGTC_522 1273-0010 4.02 11.6 µM 1.21E-5 60S ribosome export 24 2.88E-5
16 SGTC_1540 guanosine 4.00 70.6 µM 1.36E-5 8 3.19E-5
17 SGTC_1803 st050068 3.85 52.4 µM 2.70E-5 NEO1-PIK1 192 5.98E-5
18 SGTC_427 1354-0053 3.80 47.3 µM 3.31E-5 26 7.20E-5
19 SGTC_913 3487-1245 3.65 167.0 µM 6.47E-5 44 1.33E-4
20 SGTC_1251 0490-5699 3.59 265.0 µM 8.32E-5 46 1.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.221 2.23E-38 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.212 1.84E-35 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.197 1.17E-30 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.185 4.23E-27 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.177 6.33E-25 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.170 3.23E-23 YGR211W ZPR1 het Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress
0.167 2.10E-22 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.153 5.13E-19 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.152 1.06E-18 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.150 2.22E-18 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.149 3.32E-18 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.142 1.17E-16 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.142 1.60E-16 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.141 1.84E-16 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.140 3.04E-16 YHL007C STE20 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p