YOR017W / PET127

Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR017W / PET127

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:-4.39|P-value:1.05E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:2.96|P-value:6.63E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-2.99|P-value:6.23E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:2.96|P-value:6.63E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:-3.38|P-value:1.29E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.31|P-value:1.65E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.88|P-value:1.30E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.16|P-value:3.18E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:2.86|P-value:9.79E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.40|P-value:1.14E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.35|P-value:1.41E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.18|P-value:2.91E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:2.91|P-value:7.95E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.12|P-value:3.56E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.00|P-value:5.76E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.03|P-value:5.30E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.34|P-value:1.48E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.23|P-value:2.34E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.06|P-value:4.61E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.33|P-value:1.62E-4 ID:SGTC_1115|Compound:galangin|FD-Score:4.87|P-value:6.69E-8 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.25|P-value:2.13E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.14|P-value:3.31E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.86|P-value:1.45E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.43|P-value:1.02E-4 ID:SGTC_1522|Compound:st012842|FD-Score:2.93|P-value:7.51E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.95|P-value:9.50E-6 ID:SGTC_1677|Compound:st019204|FD-Score:3.16|P-value:3.13E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.85|P-value:1.49E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:2.90|P-value:8.24E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.34|P-value:1.46E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.28|P-value:1.90E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.33|P-value:1.53E-4 ID:SGTC_2197|Compound:6588183|FD-Score:-3.16|P-value:3.18E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-5.01|P-value:2.95E-8 ID:SGTC_2240|Compound:6690706|FD-Score:-3.16|P-value:3.17E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.03|P-value:5.12E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-3.34|P-value:1.50E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:2.86|P-value:9.69E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.11|P-value:3.68E-4 ID:SGTC_2853|Compound:9015042|FD-Score:6.27|P-value:5.65E-12 ID:SGTC_2923|Compound:7992654|FD-Score:-3.55|P-value:6.15E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-4.78|P-value:1.15E-7 ID:SGTC_2935|Compound:9038016|FD-Score:3.46|P-value:8.73E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.13|P-value:3.48E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.58|P-value:5.47E-5 ID:SGTC_2959|Compound:9079155|FD-Score:3.59|P-value:4.94E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.89|P-value:1.22E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.39|P-value:1.05E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:2.96|P-value:6.63E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-2.99|P-value:6.23E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:2.96|P-value:6.63E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:-3.38|P-value:1.29E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.31|P-value:1.65E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.88|P-value:1.30E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.16|P-value:3.18E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:2.86|P-value:9.79E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.40|P-value:1.14E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.35|P-value:1.41E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.18|P-value:2.91E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:2.91|P-value:7.95E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.12|P-value:3.56E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.00|P-value:5.76E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.03|P-value:5.30E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.34|P-value:1.48E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.23|P-value:2.34E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.06|P-value:4.61E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.33|P-value:1.62E-4 ID:SGTC_1115|Compound:galangin|FD-Score:4.87|P-value:6.69E-8 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.25|P-value:2.13E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.14|P-value:3.31E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.86|P-value:1.45E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.43|P-value:1.02E-4 ID:SGTC_1522|Compound:st012842|FD-Score:2.93|P-value:7.51E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.95|P-value:9.50E-6 ID:SGTC_1677|Compound:st019204|FD-Score:3.16|P-value:3.13E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.85|P-value:1.49E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:2.90|P-value:8.24E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.34|P-value:1.46E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.28|P-value:1.90E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.33|P-value:1.53E-4 ID:SGTC_2197|Compound:6588183|FD-Score:-3.16|P-value:3.18E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-5.01|P-value:2.95E-8 ID:SGTC_2240|Compound:6690706|FD-Score:-3.16|P-value:3.17E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.03|P-value:5.12E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-3.34|P-value:1.50E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:2.86|P-value:9.69E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.11|P-value:3.68E-4 ID:SGTC_2853|Compound:9015042|FD-Score:6.27|P-value:5.65E-12 ID:SGTC_2923|Compound:7992654|FD-Score:-3.55|P-value:6.15E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-4.78|P-value:1.15E-7 ID:SGTC_2935|Compound:9038016|FD-Score:3.46|P-value:8.73E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.13|P-value:3.48E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.58|P-value:5.47E-5 ID:SGTC_2959|Compound:9079155|FD-Score:3.59|P-value:4.94E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.89|P-value:1.22E-5

Top fitness defect scores for YOR017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2853 9015042 6.27 58.4 µM 5.65E-12 5 1.84E-10
2 SGTC_1115 galangin 4.87 695.7 nM 6.69E-8 RPP1 & pyrimidine depletion 2 5.66E-7
3 SGTC_3272 9137413 3.89 49.5 µM 1.22E-5 14 4.94E-5
4 SGTC_362 0310-0100 3.88 9.0 µM 1.30E-5 RPP1 & pyrimidine depletion 37 5.21E-5
5 SGTC_1340 1486-1359 3.86 257.0 µM 1.45E-5 22 5.72E-5
6 SGTC_1719 st032227 3.85 49.2 µM 1.49E-5 24 5.86E-5
7 SGTC_2959 9079155 3.59 11.0 µM 4.94E-5 40 1.64E-4
8 SGTC_2935 9038016 3.46 30.0 µM 8.73E-5 30 2.67E-4
9 SGTC_1473 k844-0725 3.43 134.0 µM 1.02E-4 32 3.05E-4
10 SGTC_384 k007-0144 3.40 5.2 µM 1.14E-4 ERAD & cell cycle 82 3.36E-4
11 SGTC_514 4466-0038 3.35 2.6 nM 1.41E-4 cell wall 195 4.03E-4
12 SGTC_2015 5119600 3.34 184.0 µM 1.46E-4 50 4.15E-4
13 SGTC_819 1013-0258 3.34 27.7 µM 1.48E-4 56 4.21E-4
14 SGTC_2112 5488546 3.33 200.0 µM 1.53E-4 TSC3-RPN4 35 4.34E-4
15 SGTC_275 trichlorophene 3.31 5.7 µM 1.65E-4 mitochondrial stress 267 4.62E-4
16 SGTC_2053 5265679 3.28 138.0 µM 1.90E-4 53 5.23E-4
17 SGTC_1167 k781-0610 3.25 148.0 µM 2.13E-4 RNA processing & uracil transport 53 5.77E-4
18 SGTC_826 1683-5028 3.23 118.0 µM 2.34E-4 36 6.24E-4
19 SGTC_1677 st019204 3.16 53.9 µM 3.13E-4 54 8.02E-4
20 SGTC_1268 0828-0275 3.14 2.5 µM 3.31E-4 57 8.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 2.63E-9 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.098 1.32E-8 YDR236C FMN1 het Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
0.092 8.95E-8 YGL050W TYW3 hom tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
0.092 1.09E-7 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.090 1.57E-7 YML011C RAD33 hom Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.088 2.92E-7 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.086 5.74E-7 YMR176W ECM5 hom Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress
0.084 1.04E-6 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.083 1.59E-6 YLR071C RGR1 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
0.081 2.57E-6 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.079 4.50E-6 YLR364W GRX8 hom Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic
0.079 4.88E-6 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.077 8.64E-6 YLR283W_p YLR283W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
0.076 9.45E-6 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.075 1.21E-5 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair