YOR020C / HSP10

Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR020C / HSP10

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.80|P-value:8.39E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.48|P-value:3.23E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.73|P-value:1.26E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.97|P-value:5.34E-7 ID:SGTC_189|Compound:3970-0742|FD-Score:3.24|P-value:6.56E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.42|P-value:3.47E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.99|P-value:3.95E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:3.43|P-value:3.38E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.12|P-value:2.45E-7 ID:SGTC_902|Compound:1120-0002|FD-Score:4.18|P-value:1.73E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:4.78|P-value:1.11E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:3.46|P-value:3.02E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.47|P-value:2.91E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.67|P-value:1.59E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.94|P-value:4.82E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.20|P-value:1.61E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.41|P-value:6.46E-6 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.21|P-value:7.40E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.22|P-value:7.13E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.16|P-value:9.89E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.99|P-value:3.89E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.64|P-value:1.54E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:5.03|P-value:3.35E-7 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.17|P-value:1.83E-5 ID:SGTC_1752|Compound:st044819|FD-Score:3.56|P-value:2.08E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.37|P-value:4.18E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.12|P-value:9.81E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.52|P-value:5.34E-14 ID:SGTC_2246|Compound:7293507|FD-Score:3.51|P-value:2.52E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.21|P-value:7.44E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.17|P-value:8.35E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.18|P-value:9.34E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.64|P-value:1.57E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.36|P-value:5.00E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.17|P-value:9.45E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-4.98|P-value:5.05E-7 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-4.03|P-value:3.85E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.27|P-value:6.71E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.60|P-value:1.80E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.32|P-value:5.06E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.13|P-value:2.22E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-3.25|P-value:7.37E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.86|P-value:7.71E-5 ID:SGTC_2862|Compound:9027634|FD-Score:-3.42|P-value:4.03E-4 ID:SGTC_2871|Compound:9038510|FD-Score:5.24|P-value:1.12E-7 ID:SGTC_2887|Compound:9044784|FD-Score:-5.83|P-value:5.15E-9 ID:SGTC_2991|Compound:9074669|FD-Score:3.94|P-value:4.75E-5 ID:SGTC_3007|Compound:9078383|FD-Score:3.82|P-value:7.70E-5 ID:SGTC_3034|Compound:9090421|FD-Score:3.32|P-value:5.03E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-4.36|P-value:9.47E-6 ID:SGTC_3065|Compound:9113888|FD-Score:-3.31|P-value:5.92E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.54|P-value:3.53E-6 ID:SGTC_3165|Compound:9101544|FD-Score:3.67|P-value:1.40E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.42|P-value:4.07E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.31|P-value:5.19E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.28|P-value:5.81E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.80|P-value:8.39E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.48|P-value:3.23E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.73|P-value:1.26E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.97|P-value:5.34E-7 ID:SGTC_189|Compound:3970-0742|FD-Score:3.24|P-value:6.56E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.42|P-value:3.47E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.99|P-value:3.95E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:3.43|P-value:3.38E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.12|P-value:2.45E-7 ID:SGTC_902|Compound:1120-0002|FD-Score:4.18|P-value:1.73E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:4.78|P-value:1.11E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:3.46|P-value:3.02E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.47|P-value:2.91E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.67|P-value:1.59E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.94|P-value:4.82E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.20|P-value:1.61E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.41|P-value:6.46E-6 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.21|P-value:7.40E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.22|P-value:7.13E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.16|P-value:9.89E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.99|P-value:3.89E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.64|P-value:1.54E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:5.03|P-value:3.35E-7 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.17|P-value:1.83E-5 ID:SGTC_1752|Compound:st044819|FD-Score:3.56|P-value:2.08E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.37|P-value:4.18E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.12|P-value:9.81E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.52|P-value:5.34E-14 ID:SGTC_2246|Compound:7293507|FD-Score:3.51|P-value:2.52E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.21|P-value:7.44E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.17|P-value:8.35E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.18|P-value:9.34E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.64|P-value:1.57E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.36|P-value:5.00E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.17|P-value:9.45E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-4.98|P-value:5.05E-7 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-4.03|P-value:3.85E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.27|P-value:6.71E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.60|P-value:1.80E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.32|P-value:5.06E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.13|P-value:2.22E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-3.25|P-value:7.37E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.86|P-value:7.71E-5 ID:SGTC_2862|Compound:9027634|FD-Score:-3.42|P-value:4.03E-4 ID:SGTC_2871|Compound:9038510|FD-Score:5.24|P-value:1.12E-7 ID:SGTC_2887|Compound:9044784|FD-Score:-5.83|P-value:5.15E-9 ID:SGTC_2991|Compound:9074669|FD-Score:3.94|P-value:4.75E-5 ID:SGTC_3007|Compound:9078383|FD-Score:3.82|P-value:7.70E-5 ID:SGTC_3034|Compound:9090421|FD-Score:3.32|P-value:5.03E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-4.36|P-value:9.47E-6 ID:SGTC_3065|Compound:9113888|FD-Score:-3.31|P-value:5.92E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.54|P-value:3.53E-6 ID:SGTC_3165|Compound:9101544|FD-Score:3.67|P-value:1.40E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.42|P-value:4.07E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.31|P-value:5.19E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.28|P-value:5.81E-4

Top fitness defect scores for YOR020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2233 sulbentine 7.52 40.4 µM 5.34E-14 18 2.65E-14 0.17
2 SGTC_2871 9038510 5.24 13.0 µM 1.12E-7 2 8.21E-8 1.24
3 SGTC_1445 4239-0156 5.03 97.7 µM 3.35E-7 1 2.51E-7 0.62
4 SGTC_906 1165-0455 4.78 526.0 µM 1.11E-6 1 8.57E-7 0.78
5 SGTC_3091 9116372 4.54 49.5 µM 3.53E-6 8 2.81E-6 0.09
6 SGTC_1177 0983-0204 4.41 23.6 µM 6.46E-6 6 5.22E-6 0.45
7 SGTC_1161 k007-0610 4.20 110.0 µM 1.61E-5 ERAD & cell cycle 38 1.33E-5 0.02
8 SGTC_902 1120-0002 4.18 2.1 µM 1.73E-5 azole & statin 17 1.43E-5 0.18
9 SGTC_1454 4239-0054 4.17 42.6 µM 1.83E-5 6 1.52E-5 0.52
10 SGTC_2703 st077852 4.13 53.4 µM 2.22E-5 6 1.85E-5 0.10
11 SGTC_1257 0669-0121 3.99 16.0 µM 3.89E-5 3 3.28E-5 0.53
12 SGTC_548 1436-0017 3.99 110.0 µM 3.95E-5 TSC3-RPN4 6 3.33E-5 0.00
13 SGTC_2991 9074669 3.94 71.4 µM 4.75E-5 azole & statin 16 4.04E-5 0.01
14 SGTC_1154 4088-0362 3.94 150.0 µM 4.82E-5 10 4.10E-5 0.12
15 SGTC_3007 9078383 3.82 71.4 µM 7.70E-5 6 6.62E-5 0.07
16 SGTC_4 0960-0234 3.80 25.7 µM 8.39E-5 Golgi 13 7.22E-5 0.13
17 SGTC_3165 9101544 3.67 49.5 µM 1.40E-4 4 1.22E-4 0.01
18 SGTC_1278 0874-0585 3.64 172.0 µM 1.54E-4 11 1.35E-4 0.12
19 SGTC_2408 sulbentine 3.64 18.4 µM 1.57E-4 39 1.37E-4 0.00
20 SGTC_2531 methyl deoxycholate 3.60 70.1 µM 1.80E-4 9 1.58E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.95E-10 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.103 2.62E-9 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.101 4.78E-9 YDL209C CWC2 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
0.091 1.41E-7 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.090 1.59E-7 YCR054C CTR86 het Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
0.090 1.69E-7 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.090 1.72E-7 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.085 7.37E-7 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.38E-6 YKL022C CDC16 het Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
0.081 2.61E-6 YDR360W_d OPI7_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.
0.080 3.23E-6 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.079 5.13E-6 YER136W GDI1 het GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
0.078 6.09E-6 YNR056C BIO5 hom Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.078 6.26E-6 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.076 9.82E-6 YMR229C RRP5 het RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress