YOR021C / SFM1

SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR021C / SFM1

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.18|P-value:4.69E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.38|P-value:2.19E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.27|P-value:3.26E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.45|P-value:1.84E-6 ID:SGTC_489|Compound:paxilline|FD-Score:3.35|P-value:2.39E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:7.62|P-value:1.32E-15 ID:SGTC_532|Compound:1548-0774|FD-Score:3.51|P-value:1.28E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.17|P-value:4.83E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.90|P-value:2.49E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:2.99|P-value:9.23E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.05|P-value:7.35E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.46|P-value:1.58E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.76|P-value:4.49E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.18|P-value:4.53E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-4.35|P-value:3.68E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.04|P-value:1.29E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.79|P-value:4.72E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.51|P-value:1.27E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.76|P-value:4.45E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.64|P-value:7.55E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:4.35|P-value:3.02E-6 ID:SGTC_1767|Compound:st044992|FD-Score:-3.20|P-value:5.00E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.24|P-value:3.63E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.24|P-value:3.71E-4 ID:SGTC_1985|Compound:st071382|FD-Score:2.99|P-value:9.28E-4 ID:SGTC_2004|Compound:4023728|FD-Score:5.01|P-value:9.58E-8 ID:SGTC_2067|Compound:5224629|FD-Score:-3.10|P-value:7.30E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.12|P-value:5.74E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-4.05|P-value:1.52E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.26|P-value:4.64E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:3.21|P-value:4.13E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.37|P-value:2.67E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.81|P-value:3.62E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.48|P-value:1.47E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.24|P-value:3.67E-4 ID:SGTC_3096|Compound:9117468|FD-Score:3.58|P-value:9.64E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.81|P-value:3.61E-5 ID:SGTC_3224|Compound:9130643|FD-Score:3.42|P-value:1.84E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.18|P-value:4.69E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.38|P-value:2.19E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.27|P-value:3.26E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.45|P-value:1.84E-6 ID:SGTC_489|Compound:paxilline|FD-Score:3.35|P-value:2.39E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:7.62|P-value:1.32E-15 ID:SGTC_532|Compound:1548-0774|FD-Score:3.51|P-value:1.28E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.17|P-value:4.83E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.90|P-value:2.49E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:2.99|P-value:9.23E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.05|P-value:7.35E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.46|P-value:1.58E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.76|P-value:4.49E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.18|P-value:4.53E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-4.35|P-value:3.68E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.04|P-value:1.29E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.79|P-value:4.72E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.51|P-value:1.27E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.76|P-value:4.45E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.64|P-value:7.55E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:4.35|P-value:3.02E-6 ID:SGTC_1767|Compound:st044992|FD-Score:-3.20|P-value:5.00E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.24|P-value:3.63E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.24|P-value:3.71E-4 ID:SGTC_1985|Compound:st071382|FD-Score:2.99|P-value:9.28E-4 ID:SGTC_2004|Compound:4023728|FD-Score:5.01|P-value:9.58E-8 ID:SGTC_2067|Compound:5224629|FD-Score:-3.10|P-value:7.30E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.12|P-value:5.74E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-4.05|P-value:1.52E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.26|P-value:4.64E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:3.21|P-value:4.13E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.37|P-value:2.67E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.81|P-value:3.62E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.48|P-value:1.47E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.24|P-value:3.67E-4 ID:SGTC_3096|Compound:9117468|FD-Score:3.58|P-value:9.64E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.81|P-value:3.61E-5 ID:SGTC_3224|Compound:9130643|FD-Score:3.42|P-value:1.84E-4

Top fitness defect scores for YOR021C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_530 4358-1714 7.62 28.0 µM 1.32E-15 2 1.30E-14
2 SGTC_2004 4023728 5.01 41.9 µM 9.58E-8 12 2.74E-7
3 SGTC_453 enantio-paf c16 4.45 10.0 µM 1.84E-6 110 4.30E-6
4 SGTC_1541 2',3',6-trimethoxyflavone 4.35 64.0 µM 3.02E-6 10 6.81E-6
5 SGTC_2638 epoxomicin 4.26 18.0 µM 4.64E-6 24 1.02E-5
6 SGTC_1051 3253-3903 4.04 78.0 µM 1.29E-5 24 2.64E-5
7 SGTC_764 1951-2361 3.90 146.0 µM 2.49E-5 38 4.87E-5
8 SGTC_3155 9099265 3.81 49.5 µM 3.61E-5 26 6.88E-5
9 SGTC_2783 7738165 3.81 71.4 µM 3.62E-5 33 6.90E-5
10 SGTC_1383 3049-0032 3.76 20.7 µM 4.45E-5 60S ribosome export 24 8.35E-5
11 SGTC_891 0929-0073 3.76 133.0 µM 4.49E-5 28 8.42E-5
12 SGTC_1421 4029-0249 3.64 71.4 µM 7.55E-5 25 1.37E-4
13 SGTC_3096 9117468 3.58 49.5 µM 9.64E-5 9 1.72E-4
14 SGTC_1116 jasmonic acid 3.51 1.6 µM 1.27E-4 32 2.21E-4
15 SGTC_532 1548-0774 3.51 215.0 µM 1.28E-4 32 2.23E-4
16 SGTC_2800 7887935 3.48 81.8 µM 1.47E-4 RPP1 & pyrimidine depletion 53 2.54E-4
17 SGTC_791 1348-1292 3.46 225.0 µM 1.58E-4 55 2.72E-4
18 SGTC_3224 9130643 3.42 49.5 µM 1.84E-4 RPP1 & pyrimidine depletion 47 3.14E-4
19 SGTC_241 5hr heat shock (37°C) + cantharidin 3.38 155.4 µM 2.19E-4 cell wall signaling 97 3.69E-4
20 SGTC_489 paxilline 3.35 115.0 µM 2.39E-4 PDR1 35 4.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 3.98E-14 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.125 3.89E-13 YPR068C HOS1 hom Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex
0.119 5.39E-12 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.118 8.26E-12 YJR062C NTA1 hom Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation
0.117 9.91E-12 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107 4.38E-10 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.107 4.86E-10 YOL113W SKM1 hom Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth
0.101 4.55E-9 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.097 2.10E-8 YOL064C MET22 hom Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway
0.094 4.28E-8 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.090 1.88E-7 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.089 2.10E-7 YNL206C RTT106 hom Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition
0.089 2.42E-7 YNL109W_d YNL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C
0.088 3.52E-7 YOR130C ORT1 hom Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
0.088 3.61E-7 YIL004C BET1 het Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins