YOR022C_p

Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR022C / YOR022C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.31|P-value:2.88E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.07|P-value:7.26E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.67|P-value:6.85E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.45|P-value:1.63E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.52|P-value:1.29E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.24|P-value:3.87E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.06|P-value:7.26E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.14|P-value:5.76E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.15|P-value:5.21E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.39|P-value:2.22E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.91|P-value:2.42E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.70|P-value:5.86E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.29|P-value:4.29E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:3.88|P-value:2.69E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.80|P-value:4.05E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:-4.19|P-value:6.98E-6 ID:SGTC_1076|Compound:itraconazole|FD-Score:-3.03|P-value:8.57E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.80|P-value:3.03E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.98|P-value:1.73E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.06|P-value:7.16E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.48|P-value:1.53E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.24|P-value:5.15E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.00|P-value:9.09E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.08|P-value:6.88E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.53|P-value:1.22E-4 ID:SGTC_1689|Compound:st020265|FD-Score:4.79|P-value:3.16E-7 ID:SGTC_1761|Compound:st044296|FD-Score:3.37|P-value:2.28E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.02|P-value:8.25E-4 ID:SGTC_1783|Compound:st039459|FD-Score:4.47|P-value:1.64E-6 ID:SGTC_1886|Compound:st057356|FD-Score:3.22|P-value:4.07E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.79|P-value:4.10E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.22|P-value:4.11E-4 ID:SGTC_1945|Compound:st075991|FD-Score:2.98|P-value:9.75E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.87|P-value:2.89E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.65|P-value:7.31E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.73|P-value:5.28E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.18|P-value:4.65E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.02|P-value:8.49E-4 ID:SGTC_2375|Compound:9072683|FD-Score:5.30|P-value:1.85E-8 ID:SGTC_2387|Compound:9077560|FD-Score:4.32|P-value:3.49E-6 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.20|P-value:4.53E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.69|P-value:6.44E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.47|P-value:1.78E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.11|P-value:6.22E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.76|P-value:3.69E-7 ID:SGTC_2801|Compound:7907800|FD-Score:-3.55|P-value:1.17E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.97|P-value:1.79E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-3.81|P-value:3.87E-5 ID:SGTC_3010|Compound:9080089|FD-Score:4.12|P-value:9.16E-6 ID:SGTC_3068|Compound:9116768|FD-Score:-3.58|P-value:1.02E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.67|P-value:6.73E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.09|P-value:6.63E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.69|P-value:6.32E-5 ID:SGTC_3267|Compound:9137951|FD-Score:3.88|P-value:2.70E-5 ID:SGTC_3272|Compound:9137413|FD-Score:4.40|P-value:2.33E-6 ID:SGTC_3344|Compound:9148862|FD-Score:-3.75|P-value:5.10E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:3.31|P-value:2.88E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.07|P-value:7.26E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.67|P-value:6.85E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.45|P-value:1.63E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.52|P-value:1.29E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.24|P-value:3.87E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.06|P-value:7.26E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.14|P-value:5.76E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.15|P-value:5.21E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.39|P-value:2.22E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.91|P-value:2.42E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.70|P-value:5.86E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.29|P-value:4.29E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:3.88|P-value:2.69E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.80|P-value:4.05E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:-4.19|P-value:6.98E-6 ID:SGTC_1076|Compound:itraconazole|FD-Score:-3.03|P-value:8.57E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.80|P-value:3.03E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.98|P-value:1.73E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.06|P-value:7.16E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.48|P-value:1.53E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.24|P-value:5.15E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.00|P-value:9.09E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.08|P-value:6.88E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.53|P-value:1.22E-4 ID:SGTC_1689|Compound:st020265|FD-Score:4.79|P-value:3.16E-7 ID:SGTC_1761|Compound:st044296|FD-Score:3.37|P-value:2.28E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.02|P-value:8.25E-4 ID:SGTC_1783|Compound:st039459|FD-Score:4.47|P-value:1.64E-6 ID:SGTC_1886|Compound:st057356|FD-Score:3.22|P-value:4.07E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.79|P-value:4.10E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.22|P-value:4.11E-4 ID:SGTC_1945|Compound:st075991|FD-Score:2.98|P-value:9.75E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.87|P-value:2.89E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.65|P-value:7.31E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.73|P-value:5.28E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.18|P-value:4.65E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.02|P-value:8.49E-4 ID:SGTC_2375|Compound:9072683|FD-Score:5.30|P-value:1.85E-8 ID:SGTC_2387|Compound:9077560|FD-Score:4.32|P-value:3.49E-6 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.20|P-value:4.53E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.69|P-value:6.44E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.47|P-value:1.78E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.11|P-value:6.22E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.76|P-value:3.69E-7 ID:SGTC_2801|Compound:7907800|FD-Score:-3.55|P-value:1.17E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.97|P-value:1.79E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-3.81|P-value:3.87E-5 ID:SGTC_3010|Compound:9080089|FD-Score:4.12|P-value:9.16E-6 ID:SGTC_3068|Compound:9116768|FD-Score:-3.58|P-value:1.02E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.67|P-value:6.73E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.09|P-value:6.63E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.69|P-value:6.32E-5 ID:SGTC_3267|Compound:9137951|FD-Score:3.88|P-value:2.70E-5 ID:SGTC_3272|Compound:9137413|FD-Score:4.40|P-value:2.33E-6 ID:SGTC_3344|Compound:9148862|FD-Score:-3.75|P-value:5.10E-5

Top fitness defect scores for YOR022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2375 9072683 5.30 200.0 µM 1.85E-8 mitochondrial processes 4 5.93E-8
2 SGTC_1125 tnp00248 4.80 1.3 µM 3.03E-7 13 7.98E-7
3 SGTC_1689 st020265 4.79 53.5 µM 3.16E-7 11 8.28E-7
4 SGTC_2700 st077718 4.76 96.8 µM 3.69E-7 5 9.56E-7
5 SGTC_432 NS 1619 4.52 61.3 µM 1.29E-6 17 3.07E-6
6 SGTC_1783 st039459 4.47 87.5 µM 1.64E-6 Golgi 13 3.83E-6
7 SGTC_3272 9137413 4.40 49.5 µM 2.33E-6 7 5.30E-6
8 SGTC_2387 9077560 4.32 195.1 µM 3.49E-6 12 7.72E-6
9 SGTC_1326 1431-2094 4.24 10.8 µM 5.15E-6 tubulin folding & SWR complex 30 1.11E-5
10 SGTC_3010 9080089 4.12 71.4 µM 9.16E-6 12 1.89E-5
11 SGTC_1133 3473-0247 3.98 50.0 µM 1.73E-5 RSC complex & mRNA processing 47 3.41E-5
12 SGTC_2804 7954240 3.97 19.5 µM 1.79E-5 30 3.53E-5
13 SGTC_794 k038-0031 3.91 316.0 µM 2.42E-5 ubiquinone biosynthesis & proteasome 109 4.68E-5
14 SGTC_999 4022-0066 3.88 22.7 µM 2.69E-5 Golgi 46 5.16E-5
15 SGTC_3267 9137951 3.88 49.5 µM 2.70E-5 6 5.16E-5
16 SGTC_1966 st070145 3.87 16.1 µM 2.89E-5 24 5.51E-5
17 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.79 70.1 µM 4.10E-5 31 7.63E-5
18 SGTC_2012 4023501 3.73 200.0 µM 5.28E-5 34 9.65E-5
19 SGTC_908 3448-7491 3.70 47.7 µM 5.86E-5 mitochondrial stress 136 1.06E-4
20 SGTC_3217 9129673 3.69 49.5 µM 6.32E-5 50 1.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.08E-17 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.108 3.20E-10 YMR144W_p YMR144W_p hom Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
0.108 3.58E-10 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.104 1.79E-9 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.102 2.65E-9 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.102 3.44E-9 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.101 5.45E-9 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.100 6.01E-9 YGL243W TAD1 hom tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
0.096 2.23E-8 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.095 3.74E-8 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.094 5.56E-8 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.093 5.84E-8 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.093 7.62E-8 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.091 1.40E-7 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.090 1.55E-7 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis