YOR024W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR024W / YOR024W

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-3.16|P-value:5.51E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.84|P-value:9.12E-10 ID:SGTC_82|Compound:0054-0107|FD-Score:-6.29|P-value:5.01E-11 ID:SGTC_113|Compound:0099-0221|FD-Score:4.18|P-value:9.89E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:3.28|P-value:4.17E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.62|P-value:1.15E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:5.34|P-value:2.50E-8 ID:SGTC_533|Compound:1222-0222|FD-Score:4.82|P-value:4.41E-7 ID:SGTC_534|Compound:k292-0788|FD-Score:4.63|P-value:1.13E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:3.04|P-value:9.97E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.06|P-value:1.73E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.28|P-value:6.45E-6 ID:SGTC_1254|Compound:0550-0035|FD-Score:-4.39|P-value:3.12E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.14|P-value:7.02E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-5.31|P-value:2.25E-8 ID:SGTC_1296|Compound:1068-0102|FD-Score:-3.23|P-value:4.38E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.19|P-value:5.71E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.39|P-value:3.83E-6 ID:SGTC_1605|Compound:st000082|FD-Score:3.04|P-value:9.95E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.13|P-value:7.20E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.11|P-value:6.75E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.16|P-value:5.60E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-3.46|P-value:1.83E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.95|P-value:2.82E-5 ID:SGTC_1999|Compound:st074831|FD-Score:3.18|P-value:5.94E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.51|P-value:1.67E-6 ID:SGTC_2075|Compound:5212009|FD-Score:3.75|P-value:6.66E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-3.07|P-value:7.78E-4 ID:SGTC_2317|Compound:5986382|FD-Score:4.69|P-value:8.68E-7 ID:SGTC_2327|Compound:6189656|FD-Score:-3.53|P-value:1.34E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.23|P-value:5.10E-4 ID:SGTC_2466|Compound:5983409|FD-Score:-3.11|P-value:6.68E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.13|P-value:1.07E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-4.40|P-value:2.98E-6 ID:SGTC_2534|Compound:helenine|FD-Score:3.30|P-value:3.93E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:4.71|P-value:7.77E-7 ID:SGTC_2702|Compound:st077768|FD-Score:4.06|P-value:1.74E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.20|P-value:5.64E-4 ID:SGTC_3192|Compound:9110362|FD-Score:4.02|P-value:2.06E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.16|P-value:5.51E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.84|P-value:9.12E-10 ID:SGTC_82|Compound:0054-0107|FD-Score:-6.29|P-value:5.01E-11 ID:SGTC_113|Compound:0099-0221|FD-Score:4.18|P-value:9.89E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:3.28|P-value:4.17E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.62|P-value:1.15E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:5.34|P-value:2.50E-8 ID:SGTC_533|Compound:1222-0222|FD-Score:4.82|P-value:4.41E-7 ID:SGTC_534|Compound:k292-0788|FD-Score:4.63|P-value:1.13E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:3.04|P-value:9.97E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.06|P-value:1.73E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.28|P-value:6.45E-6 ID:SGTC_1254|Compound:0550-0035|FD-Score:-4.39|P-value:3.12E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.14|P-value:7.02E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-5.31|P-value:2.25E-8 ID:SGTC_1296|Compound:1068-0102|FD-Score:-3.23|P-value:4.38E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.19|P-value:5.71E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.39|P-value:3.83E-6 ID:SGTC_1605|Compound:st000082|FD-Score:3.04|P-value:9.95E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.13|P-value:7.20E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.11|P-value:6.75E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.16|P-value:5.60E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-3.46|P-value:1.83E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.95|P-value:2.82E-5 ID:SGTC_1999|Compound:st074831|FD-Score:3.18|P-value:5.94E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.51|P-value:1.67E-6 ID:SGTC_2075|Compound:5212009|FD-Score:3.75|P-value:6.66E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-3.07|P-value:7.78E-4 ID:SGTC_2317|Compound:5986382|FD-Score:4.69|P-value:8.68E-7 ID:SGTC_2327|Compound:6189656|FD-Score:-3.53|P-value:1.34E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.23|P-value:5.10E-4 ID:SGTC_2466|Compound:5983409|FD-Score:-3.11|P-value:6.68E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.13|P-value:1.07E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-4.40|P-value:2.98E-6 ID:SGTC_2534|Compound:helenine|FD-Score:3.30|P-value:3.93E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:4.71|P-value:7.77E-7 ID:SGTC_2702|Compound:st077768|FD-Score:4.06|P-value:1.74E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.20|P-value:5.64E-4 ID:SGTC_3192|Compound:9110362|FD-Score:4.02|P-value:2.06E-5

Top fitness defect scores for YOR024W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_344 k064-0035 5.34 6.4 µM 2.50E-8 60S ribosome export 7 4.68E-8
2 SGTC_533 1222-0222 4.82 6.7 µM 4.41E-7 PDR1 13 7.29E-7
3 SGTC_2686 alizarin 4.71 95.4 µM 7.77E-7 RPP1 & pyrimidine depletion 20 1.26E-6
4 SGTC_2317 5986382 4.69 200.0 µM 8.68E-7 4 1.39E-6
5 SGTC_534 k292-0788 4.63 63.4 µM 1.13E-6 mitochondrial processes 16 1.80E-6
6 SGTC_1302 1159-0335 4.39 255.0 µM 3.83E-6 7 5.78E-6
7 SGTC_1253 0550-0034 4.28 176.0 µM 6.45E-6 14 9.53E-6
8 SGTC_113 0099-0221 4.18 2.5 µM 9.89E-6 18 1.43E-5
9 SGTC_1243 0416-0003 4.06 5.7 µM 1.73E-5 PDR1 27 2.45E-5
10 SGTC_2702 st077768 4.06 96.8 µM 1.74E-5 13 2.47E-5
11 SGTC_3192 9110362 4.02 49.5 µM 2.06E-5 mitochondrial processes 11 2.89E-5
12 SGTC_1985 st071382 3.95 65.5 µM 2.82E-5 21 3.91E-5
13 SGTC_2075 5212009 3.75 200.0 µM 6.66E-5 11 8.92E-5
14 SGTC_308 4092-1169 3.62 104.0 µM 1.15E-4 plasma membrane duress 62 1.50E-4
15 SGTC_2534 helenine 3.30 20.1 µM 3.93E-4 RSC complex & mRNA processing 26 4.90E-4
16 SGTC_171 k064-0041 3.28 9.7 µM 4.17E-4 heme requiring 41 5.19E-4
17 SGTC_2344 7990960 3.23 77.0 µM 5.10E-4 54 6.29E-4
18 SGTC_3141 9094609 3.20 49.5 µM 5.64E-4 iron homeostasis 69 6.92E-4
19 SGTC_1301 naphtanilide LB 3.19 4.8 µM 5.71E-4 heme requiring 31 7.01E-4
20 SGTC_1999 st074831 3.18 12.5 µM 5.94E-4 plasma membrane duress 64 7.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.44E-12 YBR086C IST2 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
0.107 6.00E-10 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.105 1.23E-9 YHR035W_p YHR035W_p hom Putative protein of unknown function; not an essential gene
0.095 3.43E-8 YIL127C_p RRT14_p hom Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.092 8.02E-8 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.088 2.93E-7 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.084 1.18E-6 YDR201W SPC19 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.082 1.82E-6 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.082 1.88E-6 YMR297W PRC1 hom Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
0.081 2.38E-6 YDR357C_p CNL1_p hom Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.080 3.52E-6 YLR360W VPS38 hom Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
0.080 4.00E-6 YOR253W NAT5 hom Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
0.077 9.01E-6 YBR114W RAD16 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.076 1.06E-5 YPR093C ASR1 hom Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein
0.075 1.24E-5 YGR124W ASN2 hom Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication