YOR027W / STI1

Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR027W / STI1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.14|P-value:9.72E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.97|P-value:4.28E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:3.22|P-value:7.33E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.67|P-value:1.42E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.61|P-value:1.51E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-3.54|P-value:2.00E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.25|P-value:5.81E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.31|P-value:4.68E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.27|P-value:6.23E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.20|P-value:7.90E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.44|P-value:3.39E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.22|P-value:7.50E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:4.31|P-value:1.01E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:6.02|P-value:1.25E-9 ID:SGTC_942|Compound:3253-1115|FD-Score:3.97|P-value:4.44E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:3.89|P-value:6.02E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:4.23|P-value:1.43E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.36|P-value:4.50E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.77|P-value:9.93E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:6.17|P-value:5.07E-10 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.18|P-value:8.59E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.22|P-value:1.52E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.35|P-value:4.66E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.15|P-value:7.97E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.38|P-value:4.27E-4 ID:SGTC_1895|Compound:st058434|FD-Score:4.94|P-value:4.98E-7 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.20|P-value:7.96E-4 ID:SGTC_1934|Compound:st074720|FD-Score:6.41|P-value:1.05E-10 ID:SGTC_1936|Compound:st074407|FD-Score:4.25|P-value:1.33E-5 ID:SGTC_1937|Compound:st074714|FD-Score:6.24|P-value:3.22E-10 ID:SGTC_2147|Compound:5545932|FD-Score:-3.31|P-value:4.68E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.35|P-value:3.96E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.38|P-value:4.26E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-4.00|P-value:3.18E-5 ID:SGTC_2471|Compound:5466956|FD-Score:3.24|P-value:6.84E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.07|P-value:2.89E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.46|P-value:3.24E-8 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.16|P-value:9.11E-4 ID:SGTC_2624|Compound:nerol|FD-Score:4.23|P-value:1.43E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.74|P-value:1.10E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.88|P-value:6.42E-5 ID:SGTC_2868|Compound:9035608|FD-Score:3.76|P-value:1.02E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-3.15|P-value:8.02E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.35|P-value:3.97E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.49|P-value:2.87E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.46|P-value:2.66E-4 ID:SGTC_2968|Compound:9090663|FD-Score:4.28|P-value:1.16E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-4.85|P-value:6.41E-7 ID:SGTC_2993|Compound:9054257|FD-Score:-3.09|P-value:9.72E-4 ID:SGTC_3094|Compound:9117742|FD-Score:4.40|P-value:6.74E-6 ID:SGTC_3194|Compound:9111903|FD-Score:3.61|P-value:1.79E-4 ID:SGTC_3197|Compound:9113331|FD-Score:5.20|P-value:1.32E-7 ID:SGTC_3289|Compound:9119912|FD-Score:3.24|P-value:6.82E-4 ID:SGTC_3317|Compound:9138495|FD-Score:5.18|P-value:1.51E-7 ID:SGTC_8|Compound:0354-0001|FD-Score:3.14|P-value:9.72E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.97|P-value:4.28E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:3.22|P-value:7.33E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.67|P-value:1.42E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.61|P-value:1.51E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-3.54|P-value:2.00E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.25|P-value:5.81E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.31|P-value:4.68E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.27|P-value:6.23E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.20|P-value:7.90E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.44|P-value:3.39E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.22|P-value:7.50E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:4.31|P-value:1.01E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:6.02|P-value:1.25E-9 ID:SGTC_942|Compound:3253-1115|FD-Score:3.97|P-value:4.44E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:3.89|P-value:6.02E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:4.23|P-value:1.43E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.36|P-value:4.50E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.77|P-value:9.93E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:6.17|P-value:5.07E-10 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.18|P-value:8.59E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.22|P-value:1.52E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.35|P-value:4.66E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.15|P-value:7.97E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.38|P-value:4.27E-4 ID:SGTC_1895|Compound:st058434|FD-Score:4.94|P-value:4.98E-7 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.20|P-value:7.96E-4 ID:SGTC_1934|Compound:st074720|FD-Score:6.41|P-value:1.05E-10 ID:SGTC_1936|Compound:st074407|FD-Score:4.25|P-value:1.33E-5 ID:SGTC_1937|Compound:st074714|FD-Score:6.24|P-value:3.22E-10 ID:SGTC_2147|Compound:5545932|FD-Score:-3.31|P-value:4.68E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.35|P-value:3.96E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.38|P-value:4.26E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-4.00|P-value:3.18E-5 ID:SGTC_2471|Compound:5466956|FD-Score:3.24|P-value:6.84E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.07|P-value:2.89E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.46|P-value:3.24E-8 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.16|P-value:9.11E-4 ID:SGTC_2624|Compound:nerol|FD-Score:4.23|P-value:1.43E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.74|P-value:1.10E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.88|P-value:6.42E-5 ID:SGTC_2868|Compound:9035608|FD-Score:3.76|P-value:1.02E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-3.15|P-value:8.02E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.35|P-value:3.97E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.49|P-value:2.87E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.46|P-value:2.66E-4 ID:SGTC_2968|Compound:9090663|FD-Score:4.28|P-value:1.16E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-4.85|P-value:6.41E-7 ID:SGTC_2993|Compound:9054257|FD-Score:-3.09|P-value:9.72E-4 ID:SGTC_3094|Compound:9117742|FD-Score:4.40|P-value:6.74E-6 ID:SGTC_3194|Compound:9111903|FD-Score:3.61|P-value:1.79E-4 ID:SGTC_3197|Compound:9113331|FD-Score:5.20|P-value:1.32E-7 ID:SGTC_3289|Compound:9119912|FD-Score:3.24|P-value:6.82E-4 ID:SGTC_3317|Compound:9138495|FD-Score:5.18|P-value:1.51E-7

Top fitness defect scores for YOR027W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1934 st074720 6.41 32.6 µM 1.05E-10 14 7.05E-11
2 SGTC_1937 st074714 6.24 47.2 µM 3.22E-10 13 2.19E-10
3 SGTC_1145 3546-0597 6.17 10.2 µM 5.07E-10 mitochondrial processes 3 3.48E-10
4 SGTC_877 0771-0151 6.02 33.1 µM 1.25E-9 2 8.72E-10
5 SGTC_2501 sodium tetradecyl sulfate 5.46 13.4 µM 3.24E-8 11 2.38E-8
6 SGTC_3197 9113331 5.20 49.5 µM 1.32E-7 12 9.90E-8
7 SGTC_3317 9138495 5.18 8.8 µM 1.51E-7 18 1.14E-7
8 SGTC_58 0957-0393 4.97 9.0 µM 4.28E-7 cell wall 286 3.27E-7
9 SGTC_1895 st058434 4.94 18.3 µM 4.98E-7 7 3.81E-7
10 SGTC_3094 9117742 4.40 49.5 µM 6.74E-6 12 5.38E-6
11 SGTC_665 3914-0008 4.31 307.0 µM 1.01E-5 13 8.13E-6
12 SGTC_2968 9090663 4.28 33.4 µM 1.16E-5 22 9.32E-6
13 SGTC_1936 st074407 4.25 74.3 µM 1.33E-5 DNA damage response 29 1.07E-5
14 SGTC_2624 nerol 4.23 100.0 µM 1.43E-5 5 1.15E-5
15 SGTC_993 3909-8757 4.23 62.7 µM 1.43E-5 20 1.16E-5
16 SGTC_1264 0783-0040 4.22 158.0 µM 1.52E-5 18 1.23E-5
17 SGTC_2499 avocadenofuran 4.07 51.5 µM 2.89E-5 32 2.36E-5
18 SGTC_942 3253-1115 3.97 227.0 µM 4.44E-5 27 3.66E-5
19 SGTC_972 1319-0219 3.89 195.0 µM 6.02E-5 28 4.99E-5
20 SGTC_2729 fluphenazine 3.88 10.7 µM 6.42E-5 17 5.32E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 2.05E-19 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.124 6.00E-13 YLR138W NHA1 hom Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH
0.121 2.40E-12 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.119 4.61E-12 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.119 4.83E-12 YDL162C_d YDL162C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
0.115 2.46E-11 YGR223C HSV2 hom Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization
0.111 1.22E-10 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.111 1.40E-10 YER072W VTC1 hom Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.110 1.60E-10 YDL189W RBS1 hom Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
0.105 1.21E-9 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.104 1.50E-9 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.103 2.26E-9 YCR043C_p YCR043C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
0.100 6.05E-9 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.099 8.79E-9 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.098 1.10E-8 YJL163C_p YJL163C_p hom Putative protein of unknown function