YOR030W / DFG16

Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR030W / DFG16

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-6.88|P-value:6.12E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.65|P-value:1.93E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:3.68|P-value:6.49E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.63|P-value:7.61E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.17|P-value:2.91E-6 ID:SGTC_123|Compound:0083-0120|FD-Score:3.60|P-value:8.19E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.32|P-value:1.59E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:5.45|P-value:9.03E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.32|P-value:6.43E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:8.98|P-value:1.53E-15 ID:SGTC_197|Compound:4544-0043|FD-Score:4.57|P-value:3.11E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.71|P-value:5.80E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:5.57|P-value:5.25E-7 ID:SGTC_227|Compound:fluconazole|FD-Score:8.65|P-value:1.52E-14 ID:SGTC_278|Compound:4092-0821|FD-Score:3.54|P-value:9.87E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:6.25|P-value:2.11E-8 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.88|P-value:2.96E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.68|P-value:6.39E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.42|P-value:5.49E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:4.56|P-value:3.24E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:9.00|P-value:1.38E-15 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.16|P-value:2.48E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:6.35|P-value:1.29E-8 ID:SGTC_555|Compound:4296-0685|FD-Score:3.57|P-value:9.03E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.63|P-value:3.95E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:4.71|P-value:1.87E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:5.35|P-value:1.39E-6 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.95|P-value:2.32E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:4.93|P-value:7.68E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.61|P-value:6.83E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:5.50|P-value:6.99E-7 ID:SGTC_720|Compound:r052-1644|FD-Score:4.43|P-value:5.26E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:4.10|P-value:1.68E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:6.54|P-value:4.87E-9 ID:SGTC_923|Compound:1900-2434|FD-Score:-4.91|P-value:6.85E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.79|P-value:3.90E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.79|P-value:4.51E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.79|P-value:4.62E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.42|P-value:1.00E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.28|P-value:8.80E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.50|P-value:9.64E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.76|P-value:5.08E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.83|P-value:3.21E-12 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.65|P-value:2.35E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.33|P-value:7.55E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.66|P-value:2.27E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.82|P-value:1.21E-5 ID:SGTC_1602|Compound:st001878|FD-Score:-4.37|P-value:5.48E-5 ID:SGTC_1656|Compound:st012921|FD-Score:3.59|P-value:8.46E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-6.66|P-value:1.97E-9 ID:SGTC_1672|Compound:st016598|FD-Score:4.19|P-value:1.23E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.71|P-value:5.95E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.02|P-value:5.50E-6 ID:SGTC_1773|Compound:st048542|FD-Score:3.55|P-value:9.60E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:7.29|P-value:7.97E-11 ID:SGTC_1797|Compound:st048695|FD-Score:3.71|P-value:5.79E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.07|P-value:4.35E-6 ID:SGTC_1801|Compound:st050089|FD-Score:4.31|P-value:8.04E-5 ID:SGTC_1803|Compound:st050068|FD-Score:6.25|P-value:2.09E-8 ID:SGTC_1827|Compound:berberine|FD-Score:3.73|P-value:5.56E-4 ID:SGTC_1829|Compound:berberine|FD-Score:5.00|P-value:5.96E-6 ID:SGTC_1834|Compound:st055981|FD-Score:-3.49|P-value:9.76E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.93|P-value:7.90E-8 ID:SGTC_1884|Compound:5633444|FD-Score:5.77|P-value:2.08E-7 ID:SGTC_1921|Compound:5740136|FD-Score:-3.65|P-value:5.97E-4 ID:SGTC_2016|Compound:5121758|FD-Score:5.03|P-value:5.15E-6 ID:SGTC_2021|Compound:4019055|FD-Score:9.38|P-value:9.04E-17 ID:SGTC_2049|Compound:5262831|FD-Score:-4.64|P-value:2.01E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.26|P-value:9.61E-5 ID:SGTC_2183|Compound:6420625|FD-Score:5.19|P-value:2.71E-6 ID:SGTC_2185|Compound:6113692|FD-Score:4.03|P-value:2.09E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:17.70|P-value:5.47E-55 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.69|P-value:2.17E-9 ID:SGTC_2254|Compound:7938975|FD-Score:5.48|P-value:7.65E-7 ID:SGTC_2257|Compound:7960413|FD-Score:5.07|P-value:4.40E-6 ID:SGTC_2261|Compound:9010538|FD-Score:3.66|P-value:6.76E-4 ID:SGTC_2283|Compound:7944793|FD-Score:7.40|P-value:4.22E-11 ID:SGTC_2289|Compound:7946404|FD-Score:7.55|P-value:1.76E-11 ID:SGTC_2416|Compound:tofa|FD-Score:4.70|P-value:1.95E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.65|P-value:7.04E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.74|P-value:5.40E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.48|P-value:4.42E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:5.35|P-value:1.39E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.86|P-value:8.42E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.78|P-value:4.66E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:7.62|P-value:1.13E-11 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.15|P-value:3.20E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:6.33|P-value:1.39E-8 ID:SGTC_2790|Compound:5423970|FD-Score:11.40|P-value:4.15E-24 ID:SGTC_2791|Compound:5663188|FD-Score:-4.61|P-value:2.23E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.33|P-value:7.57E-5 ID:SGTC_2862|Compound:9027634|FD-Score:7.02|P-value:3.71E-10 ID:SGTC_2864|Compound:9034755|FD-Score:3.91|P-value:3.09E-4 ID:SGTC_2925|Compound:9010536|FD-Score:6.78|P-value:1.34E-9 ID:SGTC_2928|Compound:9011484|FD-Score:4.14|P-value:1.45E-4 ID:SGTC_2930|Compound:9013230|FD-Score:7.01|P-value:3.83E-10 ID:SGTC_2938|Compound:9059746|FD-Score:3.93|P-value:2.89E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-5.70|P-value:2.27E-7 ID:SGTC_2948|Compound:9070189|FD-Score:4.98|P-value:6.38E-6 ID:SGTC_2974|Compound:9094440|FD-Score:4.67|P-value:2.17E-5 ID:SGTC_2991|Compound:9074669|FD-Score:4.12|P-value:1.56E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.44|P-value:5.13E-5 ID:SGTC_3018|Compound:9082602|FD-Score:4.46|P-value:4.71E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.55|P-value:3.32E-5 ID:SGTC_3077|Compound:9117319|FD-Score:4.51|P-value:3.98E-5 ID:SGTC_3078|Compound:9116413|FD-Score:5.00|P-value:5.83E-6 ID:SGTC_3152|Compound:9099253|FD-Score:9.89|P-value:1.85E-18 ID:SGTC_3212|Compound:9128307|FD-Score:-5.65|P-value:2.91E-7 ID:SGTC_3308|Compound:9128332|FD-Score:4.92|P-value:8.25E-6 ID:SGTC_3321|Compound:9137793|FD-Score:4.06|P-value:1.91E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.88|P-value:6.12E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.65|P-value:1.93E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:3.68|P-value:6.49E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.63|P-value:7.61E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.17|P-value:2.91E-6 ID:SGTC_123|Compound:0083-0120|FD-Score:3.60|P-value:8.19E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.32|P-value:1.59E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:5.45|P-value:9.03E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.32|P-value:6.43E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:8.98|P-value:1.53E-15 ID:SGTC_197|Compound:4544-0043|FD-Score:4.57|P-value:3.11E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.71|P-value:5.80E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:5.57|P-value:5.25E-7 ID:SGTC_227|Compound:fluconazole|FD-Score:8.65|P-value:1.52E-14 ID:SGTC_278|Compound:4092-0821|FD-Score:3.54|P-value:9.87E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:6.25|P-value:2.11E-8 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.88|P-value:2.96E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.68|P-value:6.39E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.42|P-value:5.49E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:4.56|P-value:3.24E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:9.00|P-value:1.38E-15 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.16|P-value:2.48E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:6.35|P-value:1.29E-8 ID:SGTC_555|Compound:4296-0685|FD-Score:3.57|P-value:9.03E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.63|P-value:3.95E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:4.71|P-value:1.87E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:5.35|P-value:1.39E-6 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.95|P-value:2.32E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:4.93|P-value:7.68E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.61|P-value:6.83E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:5.50|P-value:6.99E-7 ID:SGTC_720|Compound:r052-1644|FD-Score:4.43|P-value:5.26E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:4.10|P-value:1.68E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:6.54|P-value:4.87E-9 ID:SGTC_923|Compound:1900-2434|FD-Score:-4.91|P-value:6.85E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.79|P-value:3.90E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.79|P-value:4.51E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.79|P-value:4.62E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.42|P-value:1.00E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.28|P-value:8.80E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.50|P-value:9.64E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.76|P-value:5.08E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.83|P-value:3.21E-12 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.65|P-value:2.35E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.33|P-value:7.55E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.66|P-value:2.27E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.82|P-value:1.21E-5 ID:SGTC_1602|Compound:st001878|FD-Score:-4.37|P-value:5.48E-5 ID:SGTC_1656|Compound:st012921|FD-Score:3.59|P-value:8.46E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-6.66|P-value:1.97E-9 ID:SGTC_1672|Compound:st016598|FD-Score:4.19|P-value:1.23E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.71|P-value:5.95E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.02|P-value:5.50E-6 ID:SGTC_1773|Compound:st048542|FD-Score:3.55|P-value:9.60E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:7.29|P-value:7.97E-11 ID:SGTC_1797|Compound:st048695|FD-Score:3.71|P-value:5.79E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.07|P-value:4.35E-6 ID:SGTC_1801|Compound:st050089|FD-Score:4.31|P-value:8.04E-5 ID:SGTC_1803|Compound:st050068|FD-Score:6.25|P-value:2.09E-8 ID:SGTC_1827|Compound:berberine|FD-Score:3.73|P-value:5.56E-4 ID:SGTC_1829|Compound:berberine|FD-Score:5.00|P-value:5.96E-6 ID:SGTC_1834|Compound:st055981|FD-Score:-3.49|P-value:9.76E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.93|P-value:7.90E-8 ID:SGTC_1884|Compound:5633444|FD-Score:5.77|P-value:2.08E-7 ID:SGTC_1921|Compound:5740136|FD-Score:-3.65|P-value:5.97E-4 ID:SGTC_2016|Compound:5121758|FD-Score:5.03|P-value:5.15E-6 ID:SGTC_2021|Compound:4019055|FD-Score:9.38|P-value:9.04E-17 ID:SGTC_2049|Compound:5262831|FD-Score:-4.64|P-value:2.01E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.26|P-value:9.61E-5 ID:SGTC_2183|Compound:6420625|FD-Score:5.19|P-value:2.71E-6 ID:SGTC_2185|Compound:6113692|FD-Score:4.03|P-value:2.09E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:17.70|P-value:5.47E-55 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.69|P-value:2.17E-9 ID:SGTC_2254|Compound:7938975|FD-Score:5.48|P-value:7.65E-7 ID:SGTC_2257|Compound:7960413|FD-Score:5.07|P-value:4.40E-6 ID:SGTC_2261|Compound:9010538|FD-Score:3.66|P-value:6.76E-4 ID:SGTC_2283|Compound:7944793|FD-Score:7.40|P-value:4.22E-11 ID:SGTC_2289|Compound:7946404|FD-Score:7.55|P-value:1.76E-11 ID:SGTC_2416|Compound:tofa|FD-Score:4.70|P-value:1.95E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.65|P-value:7.04E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.74|P-value:5.40E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.48|P-value:4.42E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:5.35|P-value:1.39E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.86|P-value:8.42E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.78|P-value:4.66E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:7.62|P-value:1.13E-11 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.15|P-value:3.20E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:6.33|P-value:1.39E-8 ID:SGTC_2790|Compound:5423970|FD-Score:11.40|P-value:4.15E-24 ID:SGTC_2791|Compound:5663188|FD-Score:-4.61|P-value:2.23E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.33|P-value:7.57E-5 ID:SGTC_2862|Compound:9027634|FD-Score:7.02|P-value:3.71E-10 ID:SGTC_2864|Compound:9034755|FD-Score:3.91|P-value:3.09E-4 ID:SGTC_2925|Compound:9010536|FD-Score:6.78|P-value:1.34E-9 ID:SGTC_2928|Compound:9011484|FD-Score:4.14|P-value:1.45E-4 ID:SGTC_2930|Compound:9013230|FD-Score:7.01|P-value:3.83E-10 ID:SGTC_2938|Compound:9059746|FD-Score:3.93|P-value:2.89E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-5.70|P-value:2.27E-7 ID:SGTC_2948|Compound:9070189|FD-Score:4.98|P-value:6.38E-6 ID:SGTC_2974|Compound:9094440|FD-Score:4.67|P-value:2.17E-5 ID:SGTC_2991|Compound:9074669|FD-Score:4.12|P-value:1.56E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.44|P-value:5.13E-5 ID:SGTC_3018|Compound:9082602|FD-Score:4.46|P-value:4.71E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.55|P-value:3.32E-5 ID:SGTC_3077|Compound:9117319|FD-Score:4.51|P-value:3.98E-5 ID:SGTC_3078|Compound:9116413|FD-Score:5.00|P-value:5.83E-6 ID:SGTC_3152|Compound:9099253|FD-Score:9.89|P-value:1.85E-18 ID:SGTC_3212|Compound:9128307|FD-Score:-5.65|P-value:2.91E-7 ID:SGTC_3308|Compound:9128332|FD-Score:4.92|P-value:8.25E-6 ID:SGTC_3321|Compound:9137793|FD-Score:4.06|P-value:1.91E-4

Top fitness defect scores for YOR030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2249 haloperidol 17.70 116.4 µM 5.47E-55 ergosterol depletion effects on membrane 1 1.76E-70
2 SGTC_2790 5423970 11.40 71.4 µM 4.15E-24 endomembrane recycling 6 1.20E-30
3 SGTC_3152 9099253 9.89 49.5 µM 1.85E-18 NEO1-PIK1 24 2.30E-23
4 SGTC_2021 4019055 9.38 173.0 µM 9.04E-17 endomembrane recycling 12 3.45E-21
5 SGTC_363 0455-0021 9.00 3.1 µM 1.38E-15 azole & statin 10 1.16E-19
6 SGTC_178 4092-0806 8.98 87.5 µM 1.53E-15 ergosterol depletion effects on membrane 14 1.32E-19
7 SGTC_227 fluconazole 8.65 33.5 µM 1.52E-14 azole & statin 20 2.55E-18
8 SGTC_1317 1273-0028 7.83 910.0 nM 3.21E-12 azole & statin 17 2.52E-15
9 SGTC_2765 myclobutanil 7.62 7.7 µM 1.13E-11 azole & statin 5 1.27E-14
10 SGTC_2289 7946404 7.55 165.1 µM 1.76E-11 20 2.24E-14
11 SGTC_2283 7944793 7.40 200.0 µM 4.22E-11 1 6.93E-14
12 SGTC_1788 fluconazole 7.29 20.0 µM 7.97E-11 azole & statin 22 1.57E-13
13 SGTC_2862 9027634 7.02 71.4 µM 3.71E-10 ERG2 4 1.14E-12
14 SGTC_2930 9013230 7.01 14.9 µM 3.83E-10 heme biosynthesis & mitochondrial translocase 4 1.18E-12
15 SGTC_2925 9010536 6.78 32.5 µM 1.34E-9 azole & statin 11 5.96E-12
16 SGTC_2250 alverine citrate 6.69 130.0 µM 2.17E-9 38 1.10E-11
17 SGTC_922 1866-0035 6.54 480.0 µM 4.87E-9 excess fatty acid 16 3.13E-11
18 SGTC_525 k781-2675 6.35 26.7 µM 1.29E-8 redox potentiating 21 1.10E-10
19 SGTC_2778 tioconazole 6.33 65.1 nM 1.39E-8 ergosterol depletion effects on membrane 28 1.21E-10
20 SGTC_1803 st050068 6.25 52.4 µM 2.09E-8 NEO1-PIK1 75 2.04E-10

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Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.504 1.24E-215 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.499 2.21E-210 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.496 9.23E-208 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.466 3.32E-180 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.462 6.87E-176 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.452 1.55E-168 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.430 5.13E-151 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.338 3.68E-90 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.317 4.48E-79 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.303 3.59E-72 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.299 3.07E-70 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.280 2.74E-61 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.279 6.88E-61 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.263 7.21E-54 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.257 8.86E-52 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex